Peter C.M. van Zijl , Ph.D.

Peter C.M. van Zijl , Ph.D.'s picture
Director, F.M. Kirby Research Center

Kennedy Krieger Institute
707 N. Broadway
Baltimore, MD 21205
Phone: (443) 923-9500

Dr. Peter C. M. van Zijl is a research scientist at Kennedy Krieger Institute, as well as the founding director of the F.M. Kirby Research Center for Functional Brain Imaging. He is also a professor of radiology at the Johns Hopkins University School of Medicine.

Biographical Sketch: 

Dr. van Zijl graduated cum laude with a master's degree in inorganic chemistry and continued to obtain a doctoral degree in mathematics and physics. His thesis focused on the description of molecular alignment in magnetic fields and the changes in the nuclear magnetic resonance (NMR) spectra related to this. After completing fellowships in nuclear magnetic resonance (Carnegie Mellon University, Pittsburgh) and MRI (National Institutes of Health, National Cancer Institute), he became a research assistant professor at Georgetown University in 1990. In 1992, he was invited to join the Department of Radiology at Johns Hopkins University Medical School, where he was promoted to associate professor (1992) and professor (1997). In 1999, he became the founding director of the F.M. Kirby Research Center for Functional Brain Imaging at the Kennedy Krieger Institute. This center has since been awarded status as a National Center for Biomedical Technology Research funded by the National Center for Research Resources. Dr. van Zijl is a fellow of the International Society for Magnetic Resonance in Medicine and has received the society's gold medal award for scientific achievement. He also served on the executive committee of the Experimental NMR conference. He resides on the editorial boards of the journals: NMR in BiomedicineJournal of Magnetic ResonanceMagnetic Resonance in Medicine, and the Journal of Cerebral Blood Flow and Metabolism. He is an ad hoc member of several NIH review panels for several institutes.

Research Summary: 

Dr. van Zijl’s present research focuses on developing new methodologies for using MRI and Magnetic Resonance Spectroscopy (MRS) to study brain function and physiology. In addition, he is working on understanding the basic mechanisms of the MRI signal changes measured during functional MRI (fMRI) tests of the brain. Other interests are in mapping the wiring of the brain (axonal connections between the brains functional regions) and the design of new technologies for MRI to follow where cells are migrating, and when genes are expressed. A more recent interest is the development of bioorganic, biodegradable MRI contrast agents. The ultimate goal is to transform these technologies into fast methods that are compatible with the time available for multi-modal clinical diagnosis using MRI. He is especially dedicated to providing a comfortable scanning environment for children, where they can enjoy the experience in the MRI scanner. Dr. van Zijl's research is funded by several grants from the National Center for Research Resources and the National Institute of Biomedical Engineering and Bioengineering.

Research Publications:

Zeng H, Xu J, Yadav NN, McMahon MT, Harden B, Frueh D, van Zijl PC (2016). (15)N Heteronuclear Chemical Exchange Saturation Transfer MRI. J Am Chem Soc. 138(35), 11136-9. Abstract
Walhovd KB, Fjell AM, Brown TT, Kuperman JM, Chung Y, Hagler DJ Jr, Roddey JC, Erhart M, McCabe C, Akshoomoff N, Amaral DG, Bloss CS, Libiger O, Schork NJ, Darst BF, Casey BJ, Chang L, Ernst TM, Frazier J, Gruen JR, Kaufmann WE, Murray SS, van Zijl P, Mostofsky S, Dale AM, Pediatric Imaging, Neurocognition, and Genetics Study (2012). Long-term influence of normal variation in neonatal characteristics on human brain development. Proc Natl Acad Sci U S A. 109(49), 20089-94. Abstract
Fjell AM, Walhovd KB, Brown TT, Kuperman JM, Chung Y, Hagler DJ Jr, Venkatraman V, Roddey JC, Erhart M, McCabe C, Akshoomoff N, Amaral DG, Bloss CS, Libiger O, Darst BF, Schork NJ, Casey BJ, Chang L, Ernst TM, Gruen JR, Kaufmann WE, Kenet T, Frazier J, Murray SS, Sowell ER, van Zijl P, Mostofsky S, Jernigan TL, Dale AM, Pediatric Imaging, Neurocognition, and Genetics Study (2012). Multimodal imaging of the self-regulating developing brain. Proc Natl Acad Sci U S A. 109(48), 19620-5. Abstract
Bakken TE, Roddey JC, Djurovic S, Akshoomoff N, Amaral DG, Bloss CS, Casey BJ, Chang L, Ernst TM, Gruen JR, Jernigan TL, Kaufmann WE, Kenet T, Kennedy DN, Kuperman JM, Murray SS, Sowell ER, Rimol LM, Mattingsdal M, Melle I, Agartz I, Andreassen OA, Schork NJ, Dale AM, Alzheimer's Disease Neuroimaging Initiative, Pediatric Imaging, Neurocognition, and Genetics Study, Weiner M, Aisen P, Petersen R, Jack CR Jr, Jagust W, Trojanowki JQ, Toga AW, Beckett L, Green RC, Saykin AJ, Morris J, Liu E, Montine T, Gamst A, Thomas RG, Donohue M, Walter S, Gessert D, Sather T, Harvey D, Kornak J, Dale A, Bernstein M, Felmlee J, Fox N, Thompson P, Schuff N, Alexander G, DeCarli C, Bandy D, Koeppe RA, Foster N, Reiman EM, Chen K, Mathis C, Cairns NJ, Taylor-Reinwald L, Trojanowki JQ, Shaw L, Lee VM, Korecka M, Crawford K, Neu S, Foroud TM, Potkin S, Shen L, Kachaturian Z, Frank R, Snyder PJ, Molchan S, Kaye J, Quinn J, Lind B, Dolen S, Schneider LS, Pawluczyk S, Spann BM, Brewer J, Vanderswag H, Heidebrink JL, Lord JL, Johnson K, Doody RS, Villanueva-Meyer J, Chowdhury M, Stern Y, Honig LS, Bell KL, Morris JC, Ances B, Carroll M, Leon S, Mintun MA, Schneider S, Marson D, Griffith R, Clark D, Grossman H, Mitsis E, Romirowsky A, deToledo-Morrell L, Shah RC, Duara R, Varon D, Roberts P, Albert M, Onyike C, Kielb S, Rusinek H, de Leon MJ, Glodzik L, De Santi S, Doraiswamy PM, Petrella JR, Coleman RE, Arnold SE, Karlawish JH, Wolk D, Smith CD, Jicha G, Hardy P, Lopez OL, Oakley M, Simpson DM, Porsteinsson AP, Goldstein BS, Martin K, Makino KM, Ismail MS, Brand C, Mulnard RA, Thai G, Mc-Adams-Ortiz C, Womack K, Mathews D, Quiceno M, Diaz-Arrastia R, King R, Weiner M, Martin-Cook K, DeVous M, Levey AI, Lah JJ, Cellar JS, Burns JM, Anderson HS, Swerdlow RH, Apostolova L, Lu PH, Bartzokis G, Silverman DH, Graff-Radford NR, Parfitt F, Johnson H, Farlow MR, Hake AM, Matthews BR, Herring S, van Dyck CH, Carson RE, MacAvoy MG, Chertkow H, Bergman H, Hosein C, Black S, Stefanovic B, Caldwell C, Ging-Yuek, Hsiung R, Feldman H, Mudge B, Assaly M, Kertesz A, Rogers J, Trost D, Bernick C, Munic D, Kerwin D, Mesulam MM, Lipowski K, Wu CK, Johnson N, Sadowsky C, Martinez W, Villena T, Turner RS, Johnson K, Reynolds B, Sperling RA, Johnson KA, Marshall G, Frey M, Yesavage J, Taylor JL, Lane B, Rosen A, Tinklenberg J, Sabbagh M, Belden C, Jacobson S, Kowall N, Killiany R, Budson AE, Norbash A, Johnson PL, Obisesan TO, Wolday S, Bwayo SK, Lerner A, Hudson L, Ogrocki P, Fletcher E, Carmichael O, Olichney J, Kittur S, Borrie M, Lee TY, Bartha R, Johnson S, Asthana S, Carlsson CM, Potkin SG, Preda A, Nguyen D, Tariot P, Fleisher A, Reeder S, Bates V, Capote H, Rainka M, Scharre DW, Kataki M, Zimmerman EA, Celmins D, Brown AD, Pearlson GD, Blank K, Anderson K, Santulli RB, Schwartz ES, Sink KM, Williamson JD, Garg P, Watkins F, Ott BR, Querfurth H, Tremont G, Salloway S, Malloy P, Correia S, Rosen HJ, Miller BL, Mintzer J, Longmire CF, Spicer K, Finger E, Rachinsky I, Drost D, Jernigan T, McCabe C, Grant E, Ernst T, Kuperman J, Chung Y, Murray S, Bloss C, Darst B, Pritchett L, Saito A, Amaral D, DiNino M, Eyngorina B, Sowell E, Houston S, Soderberg L, Kaufmann W, van Zijl P, Rizzo-Busack H, Javid M, Mehta N, Ruberry E, Powers A, Rosen B, Gebhard N, Manigan H, Frazier J, Kennedy D, Yakutis L, Hill M, Gruen J, Bosson-Heenan J, Carlson H (2012). Association of common genetic variants in GPCPD1 with scaling of visual cortical surface area in humans. Proc Natl Acad Sci U S A. 109(10), 3985-90. Abstract
Lu H, Xu F, Grgac K, Liu P, Qin Q, van Zijl P (2012). Calibration and validation of TRUST MRI for the estimation of cerebral blood oxygenation. Magn Reson Med. 67(1), 42-9. Abstract
Reading SA, Oishi K, Redgrave GW, McEntee J, Shanahan M, Yoritomo N, Younes L, Mori S, Miller MI, van Zijl P, Margolis RL, Ross CA (2011). Diffuse abnormality of low to moderately organized white matter in schizophrenia. Brain Connect. 1(6), 511-9. Abstract
Hua K, Oishi K, Zhang J, Wakana S, Yoshioka T, Zhang W, Akhter KD, Li X, Huang H, Jiang H, van Zijl P, Mori S (2009). Mapping of functional areas in the human cortex based on connectivity through association fibers. Cereb Cortex. 19(8), 1889-95. Abstract
Zhang W, Olivi A, Hertig SJ, van Zijl P, Mori S (2008). Automated fiber tracking of human brain white matter using diffusion tensor imaging. Neuroimage. 42(2), 771-7. Abstract
Mori S, Oishi K, Jiang H, Jiang L, Li X, Akhter K, Hua K, Faria AV, Mahmood A, Woods R, Toga AW, Pike GB, Neto PR, Evans A, Zhang J, Huang H, Miller MI, van Zijl P, Mazziotta J (2008). Stereotaxic white matter atlas based on diffusion tensor imaging in an ICBM template. Neuroimage. 40(2), 570-82. Abstract
Wakana S, Caprihan A, Panzenboeck MM, Fallon JH, Perry M, Gollub RL, Hua K, Zhang J, Jiang H, Dubey P, Blitz A, van Zijl P, Mori S (2007). Reproducibility of quantitative tractography methods applied to cerebral white matter. Neuroimage. 36(3), 630-44. Abstract
Zhang J, Richards LJ, Miller MI, Yarowsky P, van Zijl P, Mori S (2006). Characterization of mouse brain and its development using diffusion tensor imaging and computational techniques. Conf Proc IEEE Eng Med Biol Soc. 1, 2252-5. Abstract
Dubey P, Fatemi A, Huang H, Nagae-Poetscher L, Wakana S, Barker PB, van Zijl P, Moser HW, Mori S, Raymond GV (2005). Diffusion tensor-based imaging reveals occult abnormalities in adrenomyeloneuropathy. Ann Neurol. 58(5), 758-66. Abstract
Reading SA, Yassa MA, Bakker A, Dziorny AC, Gourley LM, Yallapragada V, Rosenblatt A, Margolis RL, Aylward EH, Brandt J, Mori S, van Zijl P, Bassett SS, Ross CA (2005). Regional white matter change in pre-symptomatic Huntington's disease: a diffusion tensor imaging study. Psychiatry Res. 140(1), 55-62. Abstract
Zhang J, Miller MI, Plachez C, Richards LJ, Yarowsky P, van Zijl P, Mori S (2005). Mapping postnatal mouse brain development with diffusion tensor microimaging. Neuroimage. 26(4), 1042-51. Abstract
Wakana S, Nagae-Poetscher LM, Jiang H, van Zijl P, Golay X, Mori S (2005). Macroscopic orientation component analysis of brain white matter and thalamus based on diffusion tensor imaging. Magn Reson Med. 53(3), 649-57. Abstract
Zhang J, Chen YB, Hardwick JM, Miller MI, Plachez C, Richards LJ, Yarowsky P, van Zijl P, Mori S (2005). Magnetic resonance diffusion tensor microimaging reveals a role for Bcl-x in brain development and homeostasis. J Neurosci. 25(8), 1881-8. Abstract

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