600 North Wolfe St., Park 367B
Baltimore, MD 21287
Dr. Barker is a research scientist who works to develop magnetic resonance imaging (MRI) and spectroscopy (MRS) techniques for evaluating diseases of the human central nervous system. He also conducts research studies to determine the utility of these new techniques, particularly in the understanding and diagnosis of neurological, psychiatric and oncological diseases. At the Kennedy Krieger Institute, Dr. Barker is actively involved in research studies currently being performed at the FM Kirby Center for Functional Brain Imaging.
Dr. Barker attended Oxford University in the United Kingdom, where he received a Bachelor's of Arts degree in chemistry and a Doctor of Philosophy degree in physical chemistry. He conducted his post-doctoral research in magnetic resonance imaging and spectroscopy at the California Institute of Technology. He has been a faculty member in the Department of Radiology at Johns Hopkins since 1989. He is currently a professor of radiology and oncology at Johns Hopkins, and a research scientist at the Kennedy Krieger Institute.
Dr. Barker's current research interests include developing methods to non-invasively map out neurochemical and neurotransmitter levels in the brain in patients with brain tumors, infectious diseases, neurometabolic diseases, neurodegenerative diseases, schizophrenia and other psychiatric diseases using MRS. He is also interested in MRI techniques that can be used to non-invasively measure blood flow in the brain. A particular focus at present is to develop human MRI and MRS techniques for use at very high magnetic field strengths (7 Tesla). Dr. Barker collaborates on various MRI/MRS research projects with neurologists, neurosurgeons, oncologists and psychiatrists at Johns Hopkins and the Kennedy Krieger Institute.
Chan KL, Ouwerkerk R, Barker PB (2018). Water suppression in the human brain with hypergeometric RF pulses for single-voxel and multi-voxel MR spectroscopy. Magn Reson Med. , .
Chan KL, Oeltzschner G, Schär M, Barker PB, Edden RA (2017). Spatial Hadamard encoding of J-edited spectroscopy using slice-selective editing pulses. NMR Biomed. 30(5), .
Chan KL, Puts NA, Snoussi K, Harris AD, Barker PB, Edden RA (2017). Echo time optimization for J-difference editing of glutathione at 3T. Magn Reson Med. 77(2), 498-504.
Li X, Allen RP, Earley CJ, Liu H, Cruz TE, Edden RA, Barker PB, van Zijl PC (2016). Brain iron deficiency in idiopathic restless legs syndrome measured by quantitative magnetic susceptibility at 7 tesla. Sleep Med. 22, 75-82.
Zhou J, Zhu H, Lim M, Blair L, Quinones-Hinojosa A, Messina SA, Eberhart CG, Pomper MG, Laterra J, Barker PB, van Zijl PC, Blakeley JO (2013). Three-dimensional amide proton transfer MR imaging of gliomas: Initial experience and comparison with gadolinium enhancement. J Magn Reson Imaging. 38(5), 1119-28.
Foerster BR, Pomper MG, Callaghan BC, Petrou M, Edden RA, Mohamed MA, Welsh RC, Carlos RC, Barker PB, Feldman EL (2013). An imbalance between excitatory and inhibitory neurotransmitters in amyotrophic lateral sclerosis revealed by use of 3-T proton magnetic resonance spectroscopy. JAMA Neurol. 70(8), 1009-16.
Allen RP, Barker PB, Horská A, Earley CJ (2013). Thalamic glutamate/glutamine in restless legs syndrome: increased and related to disturbed sleep. Neurology. 80(22), 2028-34.
Unschuld PG, Edden RA, Carass A, Liu X, Shanahan M, Wang X, Oishi K, Brandt J, Bassett SS, Redgrave GW, Margolis RL, van Zijl PC, Barker PB, Ross CA (2012). Brain metabolite alterations and cognitive dysfunction in early Huntington's disease. Mov Disord. 27(7), 895-902.
Landman BA, Huang AJ, Gifford A, Vikram DS, Lim IA, Farrell JA, Bogovic JA, Hua J, Chen M, Jarso S, Smith SA, Joel S, Mori S, Pekar JJ, Barker PB, Prince JL, van Zijl PC (2011). Multi-parametric neuroimaging reproducibility: a 3-T resource study. Neuroimage. 54(4), 2854-66.
Edden RA, Smith SA, Barker PB (2010). Longitudinal and multi-echo transverse relaxation times of normal breast tissue at 3 Tesla. J Magn Reson Imaging. 32(4), 982-7.
Zhu H, Jones CK, van Zijl PC, Barker PB, Zhou J (2010). Fast 3D chemical exchange saturation transfer (CEST) imaging of the human brain. Magn Reson Med. 64(3), 638-44.
Horská A, Farage L, Bibat G, Nagae LM, Kaufmann WE, Barker PB, Naidu S (2009). Brain metabolism in Rett syndrome: age, clinical, and genotype correlations. Ann Neurol. 65(1), 90-7.
Smith SA, Edden RA, Farrell JA, Barker PB, Van Zijl PC (2008). Measurement of T1 and T2 in the cervical spinal cord at 3 tesla. Magn Reson Med. 60(1), 213-9.
Mohamed MA, Smith MA, Schlund MW, Nestadt G, Barker PB, Hoehn-Saric R (2007). Proton magnetic resonance spectroscopy in obsessive-compulsive disorder: a pilot investigation comparing treatment responders and non-responders. Psychiatry Res. 156(2), 175-9.
Bonekamp D, Nagae LM, Degaonkar M, Matson M, Abdalla WM, Barker PB, Mori S, Horská A(2007). Diffusion tensor imaging in children and adolescents: reproducibility, hemispheric, and age-related differences. Neuroimage. 34(2), 733-42.
Halbower AC, Degaonkar M, Barker PB, Earley CJ, Marcus CL, Smith PL, Prahme MC, Mahone EM (2006). Childhood obstructive sleep apnea associates with neuropsychological deficits and neuronal brain injury. PLoS Med. 3(8), e301.
Lin DD, Barker PB, Hatfield LA, Comi AM (2006). Dynamic MR perfusion and proton MR spectroscopic imaging in Sturge-Weber syndrome: correlation with neurological symptoms. J Magn Reson Imaging. 24(2), 274-81.
Barreiro CJ, Williams JA, Fitton TP, Lange MS, Blue ME, Kratz L, Barker PB, Degaonkar M, Gott VL, Troncoso JC, Johnston MV, Baumgartner WA (2006). Noninvasive assessment of brain injury in a canine model of hypothermic circulatory arrest using magnetic resonance spectroscopy. Ann Thorac Surg. 81(5), 1593-8.
Dubey P, Fatemi A, Huang H, Nagae-Poetscher L, Wakana S, Barker PB, van Zijl P, Moser HW, Mori S, Raymond GV (2005). Diffusion tensor-based imaging reveals occult abnormalities in adrenomyeloneuropathy. Ann Neurol. 58(5), 758-66.
Nagae-Poetscher LM, Bonekamp D, Barker PB, Brant LJ, Kaufmann WE, Horská A (2004). Asymmetry and gender effect in functionally lateralized cortical regions: a proton MRS imaging study. J Magn Reson Imaging. 19(1), 27-33.
Lin DD, Barker PB, Kraut MA, Comi A (2003). Early characteristics of Sturge-Weber syndrome shown by perfusion MR imaging and proton MR spectroscopic imaging. AJNR Am J Neuroradiol. 24(9), 1912-5.
Pizzini F, Fatemi AS, Barker PB, Nagae-Poetscher LM, Horská A, Zimmerman AW, Moser HW, Bibat G, Naidu S (2003). Proton MR spectroscopic imaging in Pelizaeus-Merzbacher disease. AJNR Am J Neuroradiol. 24(8), 1683-9.
Eichler FS, Itoh R, Barker PB, Mori S, Garrett ES, van Zijl PC, Moser HW, Raymond GV, Melhem ER (2002). Proton MR spectroscopic and diffusion tensor brain MR imaging in X-linked adrenoleukodystrophy: initial experience. Radiology. 225(1), 245-52.
Golay X, Gillen J, van Zijl PC, Barker PB (2002). Scan time reduction in proton magnetic resonance spectroscopic imaging of the human brain. Magn Reson Med. 47(2), 384-7.
Horská A, Kaufmann WE, Brant LJ, Naidu S, Harris JC, Barker PB (2002). In vivo quantitative proton MRSI study of brain development from childhood to adolescence. J Magn Reson Imaging. 15(2), 137-43.