Dr. Hua is an assistant professor in the F.M. Kirby Research Center for Functional Brain Imaging at Kennedy Krieger Institute. He also holds a joint appointment as an assistant professor in the Russell H. Morgan Department of Radiology at Johns Hopkins University.
Dr. Hua received his master's (2005) and doctoral (2009) degrees in biomedical engineering and electrical engineering at the Johns Hopkins University. His doctoral training centered on the development of novel MRI technologies for in vivo physiological imaging in the brain, such as protein content and cerebral blood volume.
After completing a post-doctoral fellowship in the Department of Radiology at the Johns Hopkins University from 2009 to 2010, Dr. Hua became a research associate (2011-2013) and instructor (2013) at the F.M. Kirby Center. In 2014, Dr. Hua was promoted to assistant professor in the Department of Radiology at Johns Hopkins University School of Medicine and Kennedy Krieger Institute.
Dr. Hua’s research focuses on the development of novel MRI technologies for in vivo functional, neurovascular and metabolic imaging in the brain, especially on high magnetic field (7 Tesla) human MRI scanners. In addition, he is also interested in novel MRI contrasts, such as chemical exchange saturation transfer (CEST). Using these techniques, he is working on understanding the physiological mechanisms of the functional MRI signals during brain activities in healthy subjects, as well as in neurodegenerative diseases such as Huntingdon’s disease, Alzheimer's disease and schizophrenia, and brain tumor.
Hua J, Liu P, Kim T, Donahue M, Rane S, Chen JJ, Qin Q, Kim SG (2018). MRI techniques to measure arterial and venous cerebral blood volume. Neuroimage. , . Abstract
Hua J, Brandt AS, Lee S, Blair NI, Wu Y, Lui S, Patel J, Faria AV, Lim IA, Unschuld PG, Pekar JJ, van Zijl PC, Ross CA, Margolis RL (2016). Abnormal Grey Matter Arteriolar Cerebral Blood Volume in Schizophrenia Measured With 3D Inflow-Based Vascular-Space-Occupancy MRI at 7T. Schizophr Bull. , . Abstract
Heo HY, Jones CK, Hua J, Yadav N, Agarwal S, Zhou J, van Zijl PC, Pillai JJ (2016). Whole-brain amide proton transfer (APT) and nuclear overhauser enhancement (NOE) imaging in glioma patients using low-power steady-state pulsed chemical exchange saturation transfer (CEST) imaging at 7T. J Magn Reson Imaging. 44(1), 41-50. Abstract
Hua J, Unschuld PG, Margolis RL, van Zijl PC, Ross CA (2014). Elevated arteriolar cerebral blood volume in prodromal Huntington's disease. Mov Disord. 29(3), 396-401. Abstract
Jones CK, Huang A, Xu J, Edden RA, Schär M, Hua J, Oskolkov N, Zacà D, Zhou J, McMahon MT, Pillai JJ, van Zijl PC (2013). Nuclear Overhauser enhancement (NOE) imaging in the human brain at 7T. Neuroimage. 77, 114-24. Abstract
Lu H, Hua J, van Zijl PC (2013). Noninvasive functional imaging of cerebral blood volume with vascular-space-occupancy (VASO) MRI. NMR Biomed. 26(8), 932-48. Abstract
Yadav NN, Jones CK, Hua J, Xu J, van Zijl PC (2013). Imaging of endogenous exchangeable proton signals in the human brain using frequency labeled exchange transfer imaging. Magn Reson Med. 69(4), 966-73. Abstract
Hua J, Jones CK, Qin Q, van Zijl PC (2013). Implementation of vascular-space-occupancy MRI at 7T. Magn Reson Med. 69(4), 1003-13. Abstract
van Zijl PC, Hua J, Lu H (2012). The BOLD post-stimulus undershoot, one of the most debated issues in fMRI. Neuroimage. 62(2), 1092-102. Abstract
Jones CK, Polders D, Hua J, Zhu H, Hoogduin HJ, Zhou J, Luijten P, van Zijl PC (2012). In vivo three-dimensional whole-brain pulsed steady-state chemical exchange saturation transfer at 7 T. Magn Reson Med. 67(6), 1579-89. Abstract
Hua J, Qin Q, Pekar JJ, van Zijl PC (2011). Measurement of absolute arterial cerebral blood volume in human brain without using a contrast agent. NMR Biomed. 24(10), 1313-25. Abstract
Hua J, Qin Q, Donahue MJ, Zhou J, Pekar JJ, van Zijl PC (2011). Inflow-based vascular-space-occupancy (iVASO) MRI. Magn Reson Med. 66(1), 40-56. Abstract
Hua J, Stevens RD, Huang AJ, Pekar JJ, van Zijl PC (2011). Physiological origin for the BOLD poststimulus undershoot in human brain: vascular compliance versus oxygen metabolism. J Cereb Blood Flow Metab. 31(7), 1599-611. Abstract
Landman BA, Huang AJ, Gifford A, Vikram DS, Lim IA, Farrell JA, Bogovic JA, Hua J, Chen M, Jarso S, Smith SA, Joel S, Mori S, Pekar JJ, Barker PB, Prince JL, van Zijl PC (2011). Multi-parametric neuroimaging reproducibility: a 3-T resource study. Neuroimage. 54(4), 2854-66. Abstract
Hua J, Donahue MJ, Zhao JM, Grgac K, Huang AJ, Zhou J, van Zijl PC (2009). Magnetization transfer enhanced vascular-space-occupancy (MT-VASO) functional MRI. Magn Reson Med. 61(4), 944-51. Abstract
Donahue MJ, Hua J, Pekar JJ, van Zijl PC (2009). Effect of inflow of fresh blood on vascular-space-occupancy (VASO) contrast. Magn Reson Med. 61(2), 473-80. Abstract
Zhou J, Blakeley JO, Hua J, Kim M, Laterra J, Pomper MG, van Zijl PC (2008). Practical data acquisition method for human brain tumor amide proton transfer (APT) imaging. Magn Reson Med. 60(4), 842-9. Abstract
Hua J, Jones CK, Blakeley J, Smith SA, van Zijl PC, Zhou J (2007). Quantitative description of the asymmetry in magnetization transfer effects around the water resonance in the human brain. Magn Reson Med. 58(4), 786-93.