Dr. Hua is an associate professor in the F.M. Kirby Research Center for Functional Brain Imaging at Kennedy Krieger Institute. He also holds a joint appointment as an associate professor in the Russell H. Morgan Department of Radiology at Johns Hopkins University.
Dr. Hua received his master's (2005) and doctoral (2009) degrees in biomedical engineering and electrical engineering at the Johns Hopkins University. His doctoral training centered on the development of novel MRI technologies for in vivo physiological imaging in the brain, such as protein content and cerebral blood volume.
After completing a post-doctoral fellowship in the Department of Radiology at the Johns Hopkins University from 2009 to 2010, Dr. Hua became a faculty member in the Department of Radiology at Johns Hopkins University School of Medicine and Kennedy Krieger Institute.
Dr. Hua’s research has centered on the development of novel MRI technologies for in vivo functional and physiological imaging in the brain, and the application of such methods for studies in healthy and diseased brains. These include the development of human and animal MRI methods to measure functional brain activities, cerebral perfusion and oxygen metabolism at high (3 Tesla) and ultra-high (7 Tesla and above) magnetic fields. He is particularly interested in novel MRI approaches to image small blood and lymphatic vessels in the brain.
Collaborating with clinical investigators, these techniques have been applied 1) to detect functional, vascular and metabolic abnormalities in the brain in neurodegenerative diseases such as Huntingdon’s disease (HD), Parkinson’s disease (PD), Alzheimer’s disease (AD) and mental disorders such as schizophrenia; and 2) to map brain functions and cerebrovascular reactivity for presurgical planning in patients with vascular malformations, brain tumors and epilepsy.
Hua J, Liu P, Kim T, Donahue M, Rane S, Chen JJ, Qin Q, Kim SG (2018). MRI techniques to measure arterial and venous cerebral blood volume. Neuroimage. , .
Hua J, Brandt AS, Lee S, Blair NI, Wu Y, Lui S, Patel J, Faria AV, Lim IA, Unschuld PG, Pekar JJ, van Zijl PC, Ross CA, Margolis RL (2016). Abnormal Grey Matter Arteriolar Cerebral Blood Volume in Schizophrenia Measured With 3D Inflow-Based Vascular-Space-Occupancy MRI at 7T. Schizophr Bull. , .
Heo HY, Jones CK, Hua J, Yadav N, Agarwal S, Zhou J, van Zijl PC, Pillai JJ (2016). Whole-brain amide proton transfer (APT) and nuclear overhauser enhancement (NOE) imaging in glioma patients using low-power steady-state pulsed chemical exchange saturation transfer (CEST) imaging at 7T. J Magn Reson Imaging. 44(1), 41-50.
Hua J, Unschuld PG, Margolis RL, van Zijl PC, Ross CA (2014). Elevated arteriolar cerebral blood volume in prodromal Huntington's disease. Mov Disord. 29(3), 396-401.
Jones CK, Huang A, Xu J, Edden RA, Schär M, Hua J, Oskolkov N, Zacà D, Zhou J, McMahon MT, Pillai JJ, van Zijl PC (2013). Nuclear Overhauser enhancement (NOE) imaging in the human brain at 7T. Neuroimage. 77, 114-24.
Lu H, Hua J, van Zijl PC (2013). Noninvasive functional imaging of cerebral blood volume with vascular-space-occupancy (VASO) MRI. NMR Biomed. 26(8), 932-48.
Yadav NN, Jones CK, Hua J, Xu J, van Zijl PC (2013). Imaging of endogenous exchangeable proton signals in the human brain using frequency labeled exchange transfer imaging. Magn Reson Med. 69(4), 966-73.
Hua J, Jones CK, Qin Q, van Zijl PC (2013). Implementation of vascular-space-occupancy MRI at 7T. Magn Reson Med. 69(4), 1003-13.
van Zijl PC, Hua J, Lu H (2012). The BOLD post-stimulus undershoot, one of the most debated issues in fMRI. Neuroimage. 62(2), 1092-102.
Jones CK, Polders D, Hua J, Zhu H, Hoogduin HJ, Zhou J, Luijten P, van Zijl PC (2012). In vivo three-dimensional whole-brain pulsed steady-state chemical exchange saturation transfer at 7 T. Magn Reson Med. 67(6), 1579-89.
Hua J, Qin Q, Pekar JJ, van Zijl PC (2011). Measurement of absolute arterial cerebral blood volume in human brain without using a contrast agent. NMR Biomed. 24(10), 1313-25.
Hua J, Qin Q, Donahue MJ, Zhou J, Pekar JJ, van Zijl PC (2011). Inflow-based vascular-space-occupancy (iVASO) MRI. Magn Reson Med. 66(1), 40-56.
Hua J, Stevens RD, Huang AJ, Pekar JJ, van Zijl PC (2011). Physiological origin for the BOLD poststimulus undershoot in human brain: vascular compliance versus oxygen metabolism. J Cereb Blood Flow Metab. 31(7), 1599-611.
Landman BA, Huang AJ, Gifford A, Vikram DS, Lim IA, Farrell JA, Bogovic JA, Hua J, Chen M, Jarso S, Smith SA, Joel S, Mori S, Pekar JJ, Barker PB, Prince JL, van Zijl PC (2011). Multi-parametric neuroimaging reproducibility: a 3-T resource study. Neuroimage. 54(4), 2854-66.
Hua J, Donahue MJ, Zhao JM, Grgac K, Huang AJ, Zhou J, van Zijl PC (2009). Magnetization transfer enhanced vascular-space-occupancy (MT-VASO) functional MRI. Magn Reson Med. 61(4), 944-51.
Donahue MJ, Hua J, Pekar JJ, van Zijl PC (2009). Effect of inflow of fresh blood on vascular-space-occupancy (VASO) contrast. Magn Reson Med. 61(2), 473-80.
Zhou J, Blakeley JO, Hua J, Kim M, Laterra J, Pomper MG, van Zijl PC (2008). Practical data acquisition method for human brain tumor amide proton transfer (APT) imaging. Magn Reson Med. 60(4), 842-9.
Hua J, Jones CK, Blakeley J, Smith SA, van Zijl PC, Zhou J (2007). Quantitative description of the asymmetry in magnetization transfer effects around the water resonance in the human brain. Magn Reson Med. 58(4), 786-93.