Anne Comi, M.D.

Anne Comi, M.D.'s picture
Director, Hunter Nelson Sturge-Weber Center at Kennedy Krieger Institute

Kennedy Krieger Institute
801 N. Broadway
Baltimore, MD 21205

Anne Comi, MD, is the director of the Hunter Nelson Sturge-Weber Center and an associate professor in the Division of Neurology at the Kennedy Krieger Institute and Johns Hopkins Medicine.

Biographical Sketch: 

Dr. Comi is the director of the Hunter Nelson Sturge-Weber Center at Kennedy Krieger Institute. She graduated from SUNY Buffalo School of Medicine and received her training in pediatrics at the Children's Hospital of Buffalo and her child neurology training at Johns Hopkins Medicine. Her clinical specialization is in the treatment of the neurological aspects of Sturge-Weber syndrome and other capillary malformation related disorders.

Research Summary: 

Her clinical research interests are focused on improving the early diagnosis and treatment of brain involvement in Sturge-Weber syndrome, in order to prevent ischemic brain injury in these infants and young children, and on studies to understand what causes Sturge-Weber syndrome. Her laboratory research work deals with the pathogenesis of Sturge-Weber syndrome recently shown to be caused by a somatic mutation and on developing new drug targets, screening assays, models and therapeutic strategies for Sturge-Weber syndrome. Her lab group also works on developing better neuroprotective and neuroregenerative responses to brain injury resulting from impaired blood flow to the brain.

Research Publications:

Comi A (2015). Current Therapeutic Options in Sturge-Weber Syndrome. Semin Pediatr Neurol. 22(4), 295-301. Abstract
Arora KS, Quigley HA, Comi AM, Miller RB, Jampel HD (2013). Increased choroidal thickness in patients with Sturge-Weber syndrome. JAMA Ophthalmol. 131(9), 1216-9. Abstract
Sreenivasan AK, Bachur CD, Lanier KE, Curatolo AS, Connors SM, Moses MA, Comi AM (2013). Urine vascular biomarkers in Sturge-Weber syndrome. Vasc Med. 18(3), 122-8. Abstract
Shirley MD, Tang H, Gallione CJ, Baugher JD, Frelin LP, Cohen B, North PE, Marchuk DA, Comi AM, Pevsner J (2013). Sturge-Weber syndrome and port-wine stains caused by somatic mutation in GNAQ. N Engl J Med. 368(21), 1971-9. Abstract
Lance EI, Sreenivasan AK, Zabel TA, Kossoff EH, Comi AM (2013). Aspirin use in Sturge-Weber syndrome: side effects and clinical outcomes. J Child Neurol. 28(2), 213-8. Abstract
Falahati S, Breu M, Waickman AT, Phillips AW, Arauz EJ, Snyder S, Porambo M, Goeral K, Comi AM, Wilson MA, Johnston MV, Fatemi A (2013). Ischemia-induced neuroinflammation is associated with disrupted development of oligodendrocyte progenitors in a model of periventricular leukomalacia. Dev Neurosci. 35(2-3), 182-96. Abstract
Lo W, Marchuk DA, Ball KL, Juhász C, Jordan LC, Ewen JB, Comi A, Brain Vascular Malformation Consortium National Sturge-Weber Syndrome Workgroup (2012). Updates and future horizons on the understanding, diagnosis, and treatment of Sturge-Weber syndrome brain involvement. Dev Med Child Neurol. 54(3), 214-23. Abstract
Bay MJ, Kossoff EH, Lehmann CU, Zabel TA, Comi AM (2011). Survey of aspirin use in Sturge-Weber syndrome. J Child Neurol. 26(6), 692-702. Abstract
Kossoff EH, Borsage JL, Comi AM (2010). A pilot study of the modified Atkins diet for Sturge-Weber syndrome. Epilepsy Res. 92(2-3), 240-3. Abstract
Albéri L, Chi Z, Kadam SD, Mulholland JD, Dawson VL, Gaiano N, Comi AM (2010). Neonatal stroke in mice causes long-term changes in neuronal Notch-2 expression that may contribute to prolonged injury. Stroke. 41(10 Suppl), S64-71. Abstract
Quan SY, Comi AM, Parsa CF, Irving ND, Krakowski AC, Cohen BA (2010). Effect of a single application of pulsed dye laser treatment of port-wine birthmarks on intraocular pressure. Arch Dermatol. 146(9), 1015-8. Abstract
Markowitz GJ, Kadam SD, Boothe DM, Irving ND, Comi AM (2010). The pharmacokinetics of commonly used antiepileptic drugs in immature CD1 mice. Neuroreport. 21(6), 452-6. Abstract
Ewen JB, Kossoff EH, Crone NE, Lin DD, Lakshmanan BM, Ferenc LM, Comi AM (2009). Use of quantitative EEG in infants with port-wine birthmark to assess for Sturge-Weber brain involvement. Clin Neurophysiol. 120(8), 1433-40. Abstract
Smith Pearl M, Abdalla WM, Lin DD, Comi AM, Boltshauser E, Gailloud P, Huisman TA (2009). Sturge-Weber syndrome with cerebellar involvement. J Neuroradiol. 36(1), 57-60. Abstract
Comi AM, Bellamkonda S, Ferenc LM, Cohen BA, Germain-Lee EL (2008). Central hypothyroidism and Sturge-Weber syndrome. Pediatr Neurol. 39(1), 58-62. Abstract
Jordan LC, Wityk RJ, Dowling MM, DeJong MR, Comi AM (2008). Transcranial Doppler ultrasound in children with Sturge-Weber syndrome. J Child Neurol. 23(2), 137-43. Abstract
Comi AM, Cho E, Mulholland JD, Hooper A, Li Q, Qu Y, Gary DS, McDonald JW, Johnston MV (2008). Neural stem cells reduce brain injury after unilateral carotid ligation. Pediatr Neurol. 38(2), 86-92. Abstract
Kossoff EH, Balasta M, Hatfield LM, Lehmann CU, Comi AM (2007). Self-reported treatment patterns in patients with Sturge-Weber syndrome and migraines. J Child Neurol. 22(6), 720-6. Abstract
Hatfield LA, Crone NE, Kossoff EH, Ewen JB, Pyzik PL, Lin DD, Kelley TM, Comi AM (2007). Quantitative EEG asymmetry correlates with clinical severity in unilateral Sturge-Weber syndrome. Epilepsia. 48(1), 191-5. Abstract
Comi AM, Highet BH, Mehta P, Hana Chong T, Johnston MV, Wilson MA (2006). Dextromethorphan protects male but not female mice with brain ischemia. Neuroreport. 17(12), 1319-22. Abstract
Miller RS, Ball KL, Comi AM, Germain-Lee EL (2006). Growth hormone deficiency in Sturge-Weber syndrome. Arch Dis Child. 91(4), 340-1. Abstract
Comi AM (2006). Advances in Sturge-Weber syndrome. Curr Opin Neurol. 19(2), 124-8. Abstract
Lin DD, Gailloud P, McCarthy EF, Comi AM (2006). Oromaxillofacial osseous abnormality in Sturge-Weber syndrome: case report and review of the literature. AJNR Am J Neuroradiol. 27(2), 274-7. Abstract
Kossoff EH, Hatfield LA, Ball KL, Comi AM (2005). Comorbidity of epilepsy and headache in patients with Sturge-Weber syndrome. J Child Neurol. 20(8), 678-82. Abstract
Comi AM (2003). Pathophysiology of Sturge-Weber syndrome. J Child Neurol. 18(8), 509-16. Abstract
Comi AM, Hunt P, Vawter MP, Pardo CA, Becker KG, Pevsner J (2003). Increased fibronectin expression in sturge-weber syndrome fibroblasts and brain tissue. Pediatr Res. 53(5), 762-9. Abstract

Other Publications:

Neuroprotection for Ischemic Injury in the Immature Brain

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