Anne
Comi
,
MD

Anne Comi, M.D.'s picture
Director, Hunter Nelson Sturge-Weber Center at Kennedy Krieger Institute
Kennedy Krieger Institute

801 North Broadway
Baltimore, MD 21205
United States

Centers & Programs

About

Anne Comi, MD, is the director of the Hunter Nelson Sturge-Weber Center and an associate professor in the Division of Neurology at the Kennedy Krieger Institute and Johns Hopkins Medicine.

Education

Dr. Comi is the director of the Hunter Nelson Sturge-Weber Center. She graduated from SUNY Buffalo School of Medicine and received her training in pediatrics at the Children's Hospital of Buffalo and her child neurology training at Johns Hopkins Medicine. Her clinical specialization is in the treatment of the neurological aspects of Sturge-Weber syndrome and other capillary malformation related disorders.

Research

Her clinical research interests are focused on improving the early diagnosis and treatment of brain involvement in Sturge-Weber syndrome, in order to prevent ischemic brain injury in these infants and young children, and on studies to understand what causes Sturge-Weber syndrome. Her laboratory research work deals with the pathogenesis of Sturge-Weber syndrome recently shown to be caused by a somatic mutation and on developing new drug targets, screening assays, models and therapeutic strategies for Sturge-Weber syndrome. Her lab group also works on developing better neuroprotective and neuroregenerative responses to brain injury resulting from impaired blood flow to the brain.

Research Publications

Comi A (2015). Current Therapeutic Options in Sturge-Weber Syndrome. Semin Pediatr Neurol. 22(4), 295-301. 

Arora KS, Quigley HA, Comi AM, Miller RB, Jampel HD (2013). Increased choroidal thickness in patients with Sturge-Weber syndrome. JAMA Ophthalmol. 131(9), 1216-9. 

Sreenivasan AK, Bachur CD, Lanier KE, Curatolo AS, Connors SM, Moses MA, Comi AM(2013). Urine vascular biomarkers in Sturge-Weber syndrome. Vasc Med. 18(3), 122-8. 

Shirley MD, Tang H, Gallione CJ, Baugher JD, Frelin LP, Cohen B, North PE, Marchuk DA, Comi AMPevsner J (2013). Sturge-Weber syndrome and port-wine stains caused by somatic mutation in GNAQ. N Engl J Med. 368(21), 1971-9. 

Lopez J, Yeom KW, Comi A, Van Haren K (2013). Case report of subdural hematoma in a patient with Sturge-Weber syndrome and literature review: questions and implications for therapy. J Child Neurol. 28(5), 672-5. 

Siddique L, Sreenivasan A, Comi AMGermain-Lee EL (2013). Importance of utilizing a sensitive free thyroxine assay in Sturge-Weber syndrome. J Child Neurol. 28(2), 269-74. 

Lance EI, Sreenivasan AK, Zabel TA, Kossoff EH, Comi AM (2013). Aspirin use in Sturge-Weber syndrome: side effects and clinical outcomes. J Child Neurol. 28(2), 213-8. 

Falahati S, Breu M, Waickman AT, Phillips AW, Arauz EJ, Snyder S, Porambo M, Goeral K, Comi AMWilson MAJohnston MVFatemi A (2013). Ischemia-induced neuroinflammation is associated with disrupted development of oligodendrocyte progenitors in a model of periventricular leukomalacia. Dev Neurosci. 35(2-3), 182-96. 

Kadam SD, Gucek M, Cole RN, Watkins PAComi AM (2012). Cell proliferation and oxidative stress pathways are modified in fibroblasts from Sturge-Weber syndrome patients. Arch Dermatol Res. 304(3), 229-35. 

Lo W, Marchuk DA, Ball KL, Juhász C, Jordan LC, Ewen JBComi A, Brain Vascular Malformation Consortium National Sturge-Weber Syndrome Workgroup (2012). Updates and future horizons on the understanding, diagnosis, and treatment of Sturge-Weber syndrome brain involvement. Dev Med Child Neurol. 54(3), 214-23. 

Comi AM (2011). Presentation, diagnosis, pathophysiology, and treatment of the neurological features of Sturge-Weber syndrome. Neurologist. 17(4), 179-84. 

Bay MJ, Kossoff EH, Lehmann CU, Zabel TAComi AM (2011). Survey of aspirin use in Sturge-Weber syndrome. J Child Neurol. 26(6), 692-702. 

Markowitz GJ, Kadam SDSmith DRJohnston MVComi AM (2011). Different effects of high- and low-dose phenobarbital on post-stroke seizure suppression and recovery in immature CD1 mice. Epilepsy Res. 94(3), 138-48. 

Kossoff EH, Borsage JL, Comi AM (2010). A pilot study of the modified Atkins diet for Sturge-Weber syndrome. Epilepsy Res. 92(2-3), 240-3. 

Turin EGrados MATierney E, Ferenc LM, Zabel AComi AM (2010). Behavioral and psychiatric features of Sturge-Weber syndrome. J Nerv Ment Dis. 198(12), 905-13. 

Albéri L, Chi Z, Kadam SD, Mulholland JD, Dawson VL, Gaiano N, Comi AM (2010). Neonatal stroke in mice causes long-term changes in neuronal Notch-2 expression that may contribute to prolonged injury. Stroke. 41(10 Suppl), S64-71. 

Quan SY, Comi AM, Parsa CF, Irving ND, Krakowski AC, Cohen BA (2010). Effect of a single application of pulsed dye laser treatment of port-wine birthmarks on intraocular pressure. Arch Dermatol. 146(9), 1015-8. 

Kadam SDSmith-Hicks CLSmith DR, Worley PF, Comi AM (2010). Functional integration of new neurons into hippocampal networks and poststroke comorbidities following neonatal stroke in mice. Epilepsy Behav. 18(4), 344-57. 

Markowitz GJ, Kadam SD, Boothe DM, Irving ND, Comi AM (2010). The pharmacokinetics of commonly used antiepileptic drugs in immature CD1 mice. Neuroreport. 21(6), 452-6. 

Suskauer SJTrovato MKZabel TAComi AM (2010). Physiatric findings in individuals with Sturge-Weber syndrome. Am J Phys Med Rehabil. 89(4), 323-30. 

Arulrajah S, Ertan G, M Comi A, Tekes A, Lin DL, Huisman TA (2010). MRI with diffusion-weighted imaging in children and young adults with simultaneous supra- and infratentorial manifestations of Sturge-Weber syndrome. J Neuroradiol. 37(1), 51-9. 

Zabel TAReesman JWodka EL, Gray R, Suskauer SJTurin E, Ferenc LM, Lin DD, Kossoff EH, Comi AM (2010). Neuropsychological features and risk factors in children with Sturge-Weber syndrome: four case reports. Clin Neuropsychol. 24(5), 841-59. 

Kossoff EH, Ferenc L, Comi AM (2009). An infantile-onset, severe, yet sporadic seizure pattern is common in Sturge-Weber syndrome. Epilepsia. 50(9), 2154-7. 

Kadam SD, Mulholland JD, McDonald JW, Comi AM (2009). Poststroke subgranular and rostral subventricular zone proliferation in a mouse model of neonatal stroke. J Neurosci Res. 87(12), 2653-66. 

Ewen JB, Kossoff EH, Crone NE, Lin DD, Lakshmanan BM, Ferenc LM, Comi AM (2009). Use of quantitative EEG in infants with port-wine birthmark to assess for Sturge-Weber brain involvement. Clin Neurophysiol. 120(8), 1433-40. 

Reesman J, Gray R, Suskauer SJ, Ferenc LM, Kossoff EH, Lin DD, Turin EComi AM, Brice PJ, Zabel TA (2009). Hemiparesis is a clinical correlate of general adaptive dysfunction in children and adolescents with Sturge-Weber syndrome. J Child Neurol. 24(6), 701-8. 

Comi AM, Trescher WH, Abi-Raad R, Johnston MVWilson MA (2009). Impact of age and strain on ischemic brain injury and seizures after carotid ligation in immature mice. Int J Dev Neurosci. 27(3), 271-7. 

Smith Pearl M, Abdalla WM, Lin DD, Comi AM, Boltshauser E, Gailloud P, Huisman TA (2009). Sturge-Weber syndrome with cerebellar involvement. J Neuroradiol. 36(1), 57-60. 

Kadam SD, Mulholland JD, Smith DRJohnston MVComi AM (2009). Chronic brain injury and behavioral impairments in a mouse model of term neonatal strokes. Behav Brain Res. 197(1), 77-83. 

Traa BS, Mulholland JD, Kadam SDJohnston MVComi AM (2008). Gabapentin neuroprotection and seizure suppression in immature mouse brain ischemia. Pediatr Res. 64(1), 81-5. 

Comi AM, Bellamkonda S, Ferenc LM, Cohen BAGermain-Lee EL (2008). Central hypothyroidism and Sturge-Weber syndrome. Pediatr Neurol. 39(1), 58-62. 

Kadam SD, Mulholland JD, McDonald JW, Comi AM (2008). Neurogenesis and neuronal commitment following ischemia in a new mouse model for neonatal stroke. Brain Res. 1208, 35-45. 

Jordan LC, Wityk RJ, Dowling MM, DeJong MR, Comi AM (2008). Transcranial Doppler ultrasound in children with Sturge-Weber syndrome. J Child Neurol. 23(2), 137-43. 

Comi AM, Cho E, Mulholland JD, Hooper A, Li Q, Qu Y, Gary DS, McDonald JW, Johnston MV(2008). Neural stem cells reduce brain injury after unilateral carotid ligation. Pediatr Neurol. 38(2), 86-92. 

Comi AM (2007). Sturge-Weber syndrome and epilepsy: an argument for aggressive seizure management in these patients. Expert Rev Neurother. 7(8), 951-6. 

Kossoff EH, Balasta M, Hatfield LM, Lehmann CU, Comi AM (2007). Self-reported treatment patterns in patients with Sturge-Weber syndrome and migraines. J Child Neurol. 22(6), 720-6. 

Ewen JBComi AM, Kossoff EH (2007). Myoclonic-astatic epilepsy in a child with Sturge-Weber syndrome. Pediatr Neurol. 36(2), 115-7. 

Comi AM (2007). Update on Sturge-Weber syndrome: diagnosis, treatment, quantitative measures, and controversies. Lymphat Res Biol. 5(4), 257-64. 

Hatfield LA, Crone NE, Kossoff EH, Ewen JB, Pyzik PL, Lin DD, Kelley TMComi AM (2007). Quantitative EEG asymmetry correlates with clinical severity in unilateral Sturge-Weber syndrome. Epilepsia. 48(1), 191-5. 

Comi AM, Highet BH, Mehta P, Hana Chong T, Johnston MVWilson MA (2006). Dextromethorphan protects male but not female mice with brain ischemia. Neuroreport. 17(12), 1319-22. 

Lin DD, Barker PB, Hatfield LA, Comi AM (2006). Dynamic MR perfusion and proton MR spectroscopic imaging in Sturge-Weber syndrome: correlation with neurological symptoms. J Magn Reson Imaging. 24(2), 274-81. 

Miller RS, Ball KL, Comi AMGermain-Lee EL (2006). Growth hormone deficiency in Sturge-Weber syndrome. Arch Dis Child. 91(4), 340-1. 

Comi AM (2006). Advances in Sturge-Weber syndrome. Curr Opin Neurol. 19(2), 124-8. 

Lin DD, Gailloud P, McCarthy EF, Comi AM (2006). Oromaxillofacial osseous abnormality in Sturge-Weber syndrome: case report and review of the literature. AJNR Am J Neuroradiol. 27(2), 274-7. 

Comi AM, Mehta P, Hatfield LA, Dowling MM (2005). Sturge-Weber syndrome associated with other abnormalities: a medical record and literature review. Arch Neurol. 62(12), 1924-7. 

Comi AMJohnston MVWilson MA (2005). Immature mouse unilateral carotid ligation model of stroke. J Child Neurol. 20(12), 980-3. 

Kelley TM, Hatfield LA, Lin DD, Comi AM (2005). Quantitative analysis of cerebral cortical atrophy and correlation with clinical severity in unilateral Sturge-Weber syndrome. J Child Neurol. 20(11), 867-70. 

Kossoff EH, Hatfield LA, Ball KL, Comi AM (2005). Comorbidity of epilepsy and headache in patients with Sturge-Weber syndrome. J Child Neurol. 20(8), 678-82. 

Comi AMJohnston MVWilson MA (2005). Strain variability, injury distribution, and seizure onset in a mouse model of stroke in the immature brain. Dev Neurosci. 27(2-4), 127-33. 

Comi AM, Weisz CJ, Highet BH, Johnston MVWilson MA (2004). A new model of stroke and ischemic seizures in the immature mouse. Pediatr Neurol. 31(4), 254-7. 

Lin DD, Barker PB, Kraut MA, Comi A (2003). Early characteristics of Sturge-Weber syndrome shown by perfusion MR imaging and proton MR spectroscopic imaging. AJNR Am J Neuroradiol. 24(9), 1912-5. 

Comi AM (2003). Pathophysiology of Sturge-Weber syndrome. J Child Neurol. 18(8), 509-16. 

Comi AM, Hunt P, Vawter MP, Pardo CA, Becker KG, Pevsner J (2003). Increased fibronectin expression in sturge-weber syndrome fibroblasts and brain tissue. Pediatr Res. 53(5), 762-9. 

Comi AM, Fischer R, Kossoff EH (2003). Encephalofacial angiomatosis sparing the occipital lobe and without facial nevus: on the spectrum of Sturge-Weber syndrome variants? J Child Neurol. 18(1), 35-8. 

Fisher W, Piazza CC, Bowman LGHagopian LP, Owens JC, Slevin I (1992). A comparison of two approaches for identifying reinforcers for persons with severe and profound disabilities. J Appl Behav Anal. 25(2), 491-8.

Other Publications

Neuroprotection for Ischemic Injury in the Immature Brain