Kannie W.Y. Chan, Ph.D.

Kannie W.Y. Chan, Ph.D.'s picture
Research Scientist, F.M. Kirby Research Center for Functional Brain Imaging

Kennedy Krieger Institute
707 N. Broadway
Baltimore, MD 21205
Email: ChanW@kennedykrieger.org

Dr. Kannie Chan is an assistant professor in the F.M. Kirby Research Center at Kennedy Krieger Institute. She holds a joint appointment as assistant professor at the Russell H. Morgan Department of Radiology and Radiological Science at Johns Hopkins.

Biographical Sketch: 

Dr. Kannie Chan attended The University of Hong Kong, where she received her Bachelor of Science and Doctor of philosophy degree. Her thesis focused on the development of magnetic resonance imaging (MRI) contrast agents. She conducted post-doctoral research in biomaterials and medical imaging with a focus on MRI at Department of Radiology at Johns Hopkins in 2010. Then she joined the F.M. Kirby Research Center as an instructor in 2013, and currently serves as an assistant professor at the Center.

Research Summary: 

Dr. Kannie Chan is an inorganic chemist by training and her present research focuses on the development of biomaterials and imaging techniques to facilitate the clinical translation of cell therapy and cancer therapy. One of the main imaging techniques is the chemical exchange saturation transfer (CEST), which is an emerging MRI contrast mechanism for molecular imaging. In cell therapy, a non-invasive way to monitor cell fate after transplantation has a critical role in translating cell therapy to patients. Dr. Chan has shown the use of nanoparticle, such as liposome, and hydrogel to monitor the molecular and cellular events in vivo using CEST. She is now investigating the potential applications of this system in stem cell therapy, especially neural stem cell. Liposome not only acts as nanosensor, it has been widely used in drug delivery. Dr. Chan has devised nanocarriers for chemotherapeutics to overcome barriers in cancer treatments. In the aspect of cancer imaging, she is actively developing non-invasive CEST technique to monitor glucose in tumors in animal model, which is named as glucoCEST. This is to exploit the potential of this technology in diagnosis and treatment monitoring in cancer.

Research Publications:

Yadav NN, Xu J, Bar-Shir A, Qin Q, Chan KW, Grgac K, Li W, McMahon MT, van Zijl PC (2014). Natural D-glucose as a biodegradable MRI relaxation agent. Magn Reson Med. 72(3), 823-8. Abstract
Yang M, Yu T, Wang YY, Lai SK, Zeng Q, Miao B, Tang BC, Simons BW, Ensign LM, Liu G, Chan KW, Juang CY, Mert O, Wood J, Fu J, McMahon MT, Wu TC, Hung CF, Hanes J (2014). Vaginal delivery of paclitaxel via nanoparticles with non-mucoadhesive surfaces suppresses cervical tumor growth. Adv Healthc Mater. 3(7), 1044-52. Abstract
Chan KW, Yu T, Qiao Y, Liu Q, Yang M, Patel H, Liu G, Kinzler KW, Vogelstein B, Bulte JW, van Zijl PC, Hanes J, Zhou S, McMahon MT (2014). A diaCEST MRI approach for monitoring liposomal accumulation in tumors. J Control Release. 180, 51-9. Abstract
Bar-Shir A, Liu G, Chan KW, Oskolkov N, Song X, Yadav NN, Walczak P, McMahon MT, van Zijl PC, Bulte JW, Gilad AA (2014). Human protamine-1 as an MRI reporter gene based on chemical exchange. ACS Chem Biol. 9(1), 134-8. Abstract
Liu G, Bettegowda C, Qiao Y, Staedtke V, Chan KW, Bai R, Li Y, Riggins GJ, Kinzler KW, Bulte JW, McMahon MT, Gilad AA, Vogelstein B, Zhou S, van Zijl PC (2013). Noninvasive imaging of infection after treatment with tumor-homing bacteria using Chemical Exchange Saturation Transfer (CEST) MRI. Magn Reson Med. 70(6), 1690-8. Abstract
Arifin DR, Kedziorek DA, Fu Y, Chan KW, McMahon MT, Weiss CR, Kraitchman DL, Bulte JW (2013). Microencapsulated cell tracking. NMR Biomed. 26(7), 850-9. Abstract
Chan KW, Liu G, Song X, Kim H, Yu T, Arifin DR, Gilad AA, Hanes J, Walczak P, van Zijl PC, Bulte JW, McMahon MT (2013). MRI-detectable pH nanosensors incorporated into hydrogels for in vivo sensing of transplanted-cell viability. Nat Mater. 12(3), 268-75. Abstract
Chan KW, McMahon MT, Kato Y, Liu G, Bulte JW, Bhujwalla ZM, Artemov D, van Zijl PC (2012). Natural D-glucose as a biodegradable MRI contrast agent for detecting cancer. Magn Reson Med. 68(6), 1764-73. Abstract
Liu G, Moake M, Har-el YE, Long CM, Chan KW, Cardona A, Jamil M, Walczak P, Gilad AA, Sgouros G, van Zijl PC, Bulte JW, McMahon MT (2012). In vivo multicolor molecular MR imaging using diamagnetic chemical exchange saturation transfer liposomes. Magn Reson Med. 67(4), 1106-13. Abstract

Other Publications:

Yu T, Chan KW, Anonuevo A, Song X, Schuster BS, Chattopadhyay S3, Xu Q, Oskolkov N, Patel H, Ensign LM, van Zjil PC, McMahon MT, Hanes J. (2014). Liposomal mucus-penetrating particles (MPP) for efficient mucosal delivery and intravaginal diamagnetic chemical exchange saturation transfer (diaCEST) magnetic resonance imaging (MRI). Nanomedicine: Nanotechnology, Biology and Medicine. doi: 10.1016/j.nano.2014.09.019.

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