Stewart H. Mostofsky, MD

Stewart H. Mostofsky, M.D.'s picture
Director, Center for Neurodevelopmental Medicine & Research

Kennedy Krieger Institute
707 N. Broadway
Baltimore, MD 21205
Phone: (443) 923-9266

Dr. Stewart Mostofsky is a research scientist and director of the Center for Neurodevelopmental and Imaging Research (CNIR) at Kennedy Krieger Institute. He is also a professor of neurology at the Johns Hopkins University School of Medicine.

Biographical Sketch: 

Dr. Mostofsky received his medical degree in 1990 through the Rensselaer Polytechnic Institute-Albany Medical College six-year program, where he won the Jack Spitalny Prize for exceptional achievement in pediatrics. He went on to an internship and residencies in pediatrics and pediatric neurology at the University of Minnesota. Dr. Mostofsky first came to Kennedy Krieger Institute in 1995 for a fellowship in the Department of Developmental Cognitive Neurology, and stayed on as a pediatric neurologist, with subspecialty training and experience in behavioral neurology as it applies to the study of childhood developmental disorders. Dr. Mostofsky is the director of Kennedy Krieger Institute's Center for Neurodevelopmental and Imaging Research (CNIR), which focuses on understanding the neurological basis of developmental disorders, including autism and attention deficit hyperactivity disorder (ADHD).

Dr. Mostofsky’s clinical practice focuses on serving children in the autism spectrum and he serves as the medical director of the Center for Autism and Related Disorders (CARD) at Kennedy Krieger Institute. He is a member of the American Academy of Neurology, the Child Neurology Society, the International Neuropsychological Society, the Society for Cognitive Neuroscience, the Society for Behavioral and Cognitive Neurology and the Organization for Human Brain Mapping.

Research Summary: 

In the Center for Neurodevelopmental and Imaging Research (CNIR), Dr. Mostofsky investigates the biological basis of developmental disorders using both structural and functional imaging techniques and experimental neurobehavioral paradigms, including motor, sensory/perceptual, and cognitive testing. These methods are used to improve our understanding of the neurologic basis of autism and ADHD, and to guide development of novel intervention strategies. This work has been supported by grants from the NIH (NINDS and NIMH) and the Autism Speaks Foundation.

Dr. Mostofsky’s research with children with autism is focused on careful examination of the motor function, as increased insight into the brain mechanisms underlying the disorder might be gained from careful consideration of the motor signs associated with autism. Dr. Mostofsky has made important contributions to identifying the common factors underlying motor impairments in autism and how anomalous patterns of motor learning in autism may contribute to the impaired social and communicative deficits that define the disorder. He is now leveraging these findings to develop novel game-based intervention strategies for children with autism.

Dr. Mostofsky is also working to pinpoint the neural systems affected in ADHD and to help identify mechanisms for effective therapeutic intervention. This investigative work has led to important insights into how impairments in response selection and control (of behavior ranging from basic motor execution to higher level cognition) contribute to the excessive impulsive, hyperactive, and off-task ("distractible") behavior. Guided by these findings, Dr. Mostofsky is now examining the efficacy of novel movement-based intervention strategies, including mindfulness practice.

Research Studies:

  • Children, Ages 36-54 Months, With an Autism Spectrum Disorder
  • Children, Ages 8-18, With and Without Autism Spectrum Disorders
  • Children, Ages 8-12, With and Without Autism Spectrum Disorders

Research Publications:

Vasa RA, Kreiser NL, Keefer A, Singh V, Mostofsky SH (2018). Relationships between autism spectrum disorder and intolerance of uncertainty. Autism Res. 11(4), 636-644. Abstract
Di Martino A, O'Connor D, Chen B, Alaerts K, Anderson JS, Assaf M, Balsters JH, Baxter L, Beggiato A, Bernaerts S, Blanken LM, Bookheimer SY, Braden BB, Byrge L, Castellanos FX, Dapretto M, Delorme R, Fair DA, Fishman I, Fitzgerald J, Gallagher L, Keehn RJ, Kennedy DP, Lainhart JE, Luna B, Mostofsky SH, Müller RA, Nebel MB, Nigg JT, O'Hearn K, Solomon M, Toro R, Vaidya CJ, Wenderoth N, White T, Craddock RC, Lord C, Leventhal B, Milham MP (2017). Enhancing studies of the connectome in autism using the autism brain imaging data exchange II. Sci Data. 4, 170010. Abstract
Wodka EL, Puts NA, Mahone EM, Edden RA, Tommerdahl M, Mostofsky SH (2016). The Role of Attention in Somatosensory Processing: A Multi-trait, Multi-method Analysis. J Autism Dev Disord. 46(10), 3232-41. Abstract
Sharer EA, Mostofsky SH, Pascual-Leone A, Oberman LM (2016). Isolating Visual and Proprioceptive Components of Motor Sequence Learning in ASD. Autism Res. 9(5), 563-9. Abstract
Floris DL, Barber AD, Nebel MB, Martinelli M, Lai MC, Crocetti D, Baron-Cohen S, Suckling J, Pekar JJ, Mostofsky SH (2016). Atypical lateralization of motor circuit functional connectivity in children with autism is associated with motor deficits. Mol Autism. 7, 35. Abstract
Germain B, Eppinger MA, Mostofsky SH, DiCicco-Bloom E, Maria BL (2015). Recent Advances in Understanding and Managing Autism Spectrum Disorders. J Child Neurol. 30(14), 1887-920. Abstract
Sharer E, Crocetti D, Muschelli J, Barber AD, Nebel MB, Caffo BS, Pekar JJ, Mostofsky SH (2015). Neural Correlates of Visuomotor Learning in Autism. J Child Neurol. 30(14), 1877-86. Abstract
Ranta ME, Chen M, Crocetti D, Prince JL, Subramaniam K, Fischl B, Kaufmann WE, Mostofsky SH (2014). Automated MRI parcellation of the frontal lobe. Hum Brain Mapp. 35(5), 2009-26. Abstract
Nebel MB, Joel SE, Muschelli J, Barber AD, Caffo BS, Pekar JJ, Mostofsky SH (2014). Disruption of functional organization within the primary motor cortex in children with autism. Hum Brain Mapp. 35(2), 567-80. Abstract
Wu SW, Gilbert DL, Shahana N, Huddleston DA, Mostofsky SH (2012). Transcranial magnetic stimulation measures in attention-deficit/hyperactivity disorder. Pediatr Neurol. 47(3), 177-85. Abstract
Edden RA, Crocetti D, Zhu H, Gilbert DL, Mostofsky SH (2012). Reduced GABA concentration in attention-deficit/hyperactivity disorder. Arch Gen Psychiatry. 69(7), 750-3. Abstract
MacNeil LK, Mostofsky SH (2012). Specificity of dyspraxia in children with autism. Neuropsychology. 26(2), 165-71. Abstract
Mahone EM, Ranta ME, Crocetti D, O'Brien J, Kaufmann WE, Denckla MB, Mostofsky SH (2011). Comprehensive examination of frontal regions in boys and girls with attention-deficit/hyperactivity disorder. J Int Neuropsychol Soc. 17(6), 1047-57. Abstract
Mahone EM, Crocetti D, Ranta ME, Gaddis A, Cataldo M, Slifer KJ, Denckla MB, Mostofsky SH (2011). A preliminary neuroimaging study of preschool children with ADHD. Clin Neuropsychol. 25(6), 1009-28. Abstract
Gilbert DL, Isaacs KM, Augusta M, Macneil LK, Mostofsky SH (2011). Motor cortex inhibition: a marker of ADHD behavior and motor development in children. Neurology. 76(7), 615-21. Abstract
Macneil LK, Xavier P, Garvey MA, Gilbert DL, Ranta ME, Denckla MB, Mostofsky SH (2011). Quantifying excessive mirror overflow in children with attention-deficit/hyperactivity disorder. Neurology. 76(7), 622-8. Abstract
Vasa RA, Pine DS, Thorn JM, Nelson TE, Spinelli S, Nelson E, Maheu FS, Ernst M, Bruck M, Mostofsky SH (2011). Enhanced right amygdala activity in adolescents during encoding of positively valenced pictures. Dev Cogn Neurosci. 1(1), 88-99. Abstract
Qiu A, Adler M, Crocetti D, Miller MI, Mostofsky SH (2010). Basal ganglia shapes predict social, communication, and motor dysfunctions in boys with autism spectrum disorder. J Am Acad Child Adolesc Psychiatry. 49(6), 539-51, 551.e1-4. Abstract
Haswell CC, Izawa J, Dowell LR, Mostofsky SH, Shadmehr R (2009). Representation of internal models of action in the autistic brain. Nat Neurosci. 12(8), 970-2. Abstract
Qiu A, Crocetti D, Adler M, Mahone EM, Denckla MB, Miller MI, Mostofsky SH (2009). Basal ganglia volume and shape in children with attention deficit hyperactivity disorder. Am J Psychiatry. 166(1), 74-82. Abstract
Wolosin SM, Richardson ME, Hennessey JG, Denckla MB, Mostofsky SH (2009). Abnormal cerebral cortex structure in children with ADHD. Hum Brain Mapp. 30(1), 175-84. Abstract
Gidley Larson JC, Bastian AJ, Donchin O, Shadmehr R, Mostofsky SH (2008). Acquisition of internal models of motor tasks in children with autism. Brain. 131(Pt 11), 2894-903. Abstract
Dziuk MA, Gidley Larson JC, Apostu A, Mahone EM, Denckla MB, Mostofsky SH (2007). Dyspraxia in autism: association with motor, social, and communicative deficits. Dev Med Child Neurol. 49(10), 734-9. Abstract
Mostofsky SH, Burgess MP, Gidley Larson JC (2007). Increased motor cortex white matter volume predicts motor impairment in autism. Brain. 130(Pt 8), 2117-22. Abstract
Wodka EL, Mahone EM, Blankner JG, Larson JC, Fotedar S, Denckla MB, Mostofsky SH (2007). Evidence that response inhibition is a primary deficit in ADHD. J Clin Exp Neuropsychol. 29(4), 345-56. Abstract
Mahone EM, Powell SK, Loftis CW, Goldberg MC, Denckla MB, Mostofsky SH (2006). Motor persistence and inhibition in autism and ADHD. J Int Neuropsychol Soc. 12(5), 622-31. Abstract
Jansiewicz EM, Newschaffer CJ, Denckla MB, Mostofsky SH (2004). Impaired habituation in children with attention deficit hyperactivity disorder. Cogn Behav Neurol. 17(1), 1-8. Abstract

Other Publications:

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