Galit Pelled, Ph.D.

Galit Pelled, Ph.D.'s picture
Research Scientist, Kennedy Krieger Institute

Kennedy Krieger Institute
707 N. Broadway
Baltimore, MD 21205
Phone: (443) 923-2751
Email: Pelled@kennedykrieger.org

Galit Pelled is an Associate Professor at the Kennedy Krieger Institute and the Department of Radiology at the Johns Hopkins University School of Medicine.

Biographical Sketch: 

Dr. Pelled graduated from the Hebrew University (Jerusalem, Israel) at 2004 and completed her post-doctoral fellowship at the National Institutes of Health (Bethesda, MD) at 2008.

Research Summary: 

At the Pelled Lab, we are dedicated to researching neuroplasticity mechanisms that are involved in reshaping brain function after injury. We work with animal models of peripheral nerve injury, traumatic brain injury, spinal cord injury and epilepsy. We focus on identifying neuroplasticity mechanisms, and understanding how they are translated into behavior and recovery. We are particularly interested in developing new strategies to facilitate neurorehabilitation.

We have recently developed a new technology that will allow scientists to control the activity of specific brain regions with high precision. This technology relies on a combination of a new gene, that we have discovered, and an external transmitter that can switch on and off neurons function in the brain.  Thus, scientists can modulate neuronal function (a process known as neuromodulation) via induction with non-invasive magnetic fields. The gene – called EPG (electromagnetic-perceptive gene) - was discovered in a fish that navigates according to the earth magnetic field. The implications of such a technology could be significant for basic scientific research, and future clinical applications. 

Research Publications:

Gilad AA, Pelled G (2015). New approaches for the neuroimaging of gene expression. Front Integr Neurosci. 9, 5. Abstract
Jouroukhin Y, Nonyane BA, Gilad AA, Pelled G (2014). Molecular neuroimaging of post-injury plasticity. J Mol Neurosci. 54(4), 630-8. Abstract
Li N, Yang Y, Glover DP, Zhang J, Saraswati M, Robertson C, Pelled G (2014). Evidence for impaired plasticity after traumatic brain injury in the developing brain. J Neurotrauma. 31(4), 395-403. Abstract
Han Y, Li N, Zeiler SR, Pelled G (2013). Peripheral nerve injury induces immediate increases in layer v neuronal activity. Neurorehabil Neural Repair. 27(7), 664-72. Abstract
Airan RD, Li N, Gilad AA, Pelled G (2013). Genetic tools to manipulate MRI contrast. NMR Biomed. 26(7), 803-9. Abstract
Airan RD, Bar-Shir A, Liu G, Pelled G, McMahon MT, van Zijl PC, Bulte JW, Gilad AA (2012). MRI biosensor for protein kinase A encoded by a single synthetic gene. Magn Reson Med. 68(6), 1919-23. Abstract
Li N, Downey JE, Bar-Shir A, Gilad AA, Walczak P, Kim H, Joel SE, Pekar JJ, Thakor NV, Pelled G (2011). Optogenetic-guided cortical plasticity after nerve injury. Proc Natl Acad Sci U S A. 108(21), 8838-43. Abstract
Pelled G (2011). MRI of neuronal plasticity in rodent models. Methods Mol Biol. 711, 567-78. Abstract
Pelled G, Bergstrom DA, Tierney PL, Conroy RS, Chuang KH, Yu D, Leopold DA, Walters JR, Koretsky AP (2009). Ipsilateral cortical fMRI responses after peripheral nerve damage in rats reflect increased interneuron activity. Proc Natl Acad Sci U S A. 106(33), 14114-9. Abstract
Tucciarone J, Chuang KH, Dodd SJ, Silva A, Pelled G, Koretsky AP (2009). Layer specific tracing of corticocortical and thalamocortical connectivity in the rodent using manganese enhanced MRI. Neuroimage. 44(3), 923-31. Abstract
Silva AC, Lee JH, Wu CW, Tucciarone J, Pelled G, Aoki I, Koretsky AP (2008). Detection of cortical laminar architecture using manganese-enhanced MRI. J Neurosci Methods. 167(2), 246-57. Abstract
Pelled G, Bergman H, Ben-Hur T, Goelman G (2007). Manganese-enhanced MRI in a rat model of Parkinson's disease. J Magn Reson Imaging. 26(4), 863-70. Abstract
Pelled G, Goelman G (2004). Different physiological MRI noise between cortical layers. Magn Reson Med. 52(4), 913-6. Abstract
Roth-Deri I, Zangen A, Aleli M, Goelman RG, Pelled G, Nakash R, Gispan-Herman I, Green T, Shaham Y, Yadid G (2003). Effect of experimenter-delivered and self-administered cocaine on extracellular beta-endorphin levels in the nucleus accumbens. J Neurochem. 84(5), 930-8. Abstract

Other Publications:

Silva AC, Lee J-H, Wu CWH, Tucciarone J, Pelled G, Aoki I, Koretsky AP. Cortical laminar architecture detected non-invasively using manganese-Enhanced MRI. J Neurosci Meth. 2007;167(2):246-257. 

Li N, Downey J, Bar-Shir A,  Gilad AA, Walczak P, Kim H, Joel SE, Pekar JJ, Thakor NV & Pelled G. Optogenetic-guided cortical plasticity following nerve injury. Proc Natl Acad Sci U S A. 2011

Park S., Sorrell M., Tian Y., Banerjee J., Wright J., Guggino W., Gilad, AA. & Pelled, G. Remote control of cellular function by activation of a putative ion channel responsive to electromagnetic fields. (In revisions)

Banerjee J, Sorrell M, Celnik P, Pelled G. ”Immediate effects of repetitive magnetic stimulation on single cortical pyramidal neurons”. (In review)

Shin S and Pelled G. Novel Neuromodulation Techniques to Modulate Interhemispheric Communication in Brain Injury and Neurodegenerative Diseases“, (In review)

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