Shilpa Kadam, Ph.D.

Shilpa Kadam
Shilpa Kadam
Research Scientist and Director of the Mouse In-Vivo Electrophysiology Laboratory, Kennedy Krieger Institute

Kennedy Krieger Institute
716 N. Broadway
Baltimore, MD 21205
Phone: (443) 923-2688

Dr. Shilpa Kadam is a research scientist at the Hugo W. Moser Research Institute at Kennedy Krieger. She is an assistant professor of neurology at the Kennedy Krieger Institute and Johns Hopkins University School of Medicine. She is also the director of the mouse in-vivo electrophysiology laboratory at the Kennedy Krieger Institute.

Biographical Sketch:

Shilpa Kadam graduated with her diploma in alternative medicine and completed her internship at Sanjeevan General Hospital in Pune, India. After graduation, she trained/worked as a medical officer at the Pune Institute of Neurology in the intensive care and high dependency units. She completed her doctoral degree in the United States in the field epilepsy research in the lab of Dr. F. E. Dudek (University of Utah School of Medicine), in 2006. She did her post-doctoral fellowship training in the Department of Neurology at the Johns Hopkins University School of Medicine. In 2008, she joined the faculty of the Neurology Department.

Research Summary:

Dr. Kadam's doctoral research involved the study of epileptogenesis using in vivo ECOG monitoring using telemetry and in vitro slice electrophysiology in a rat model of perinatal hypoxia-ischemia. During her fellowship training at Hopkins, she helped complete projects investigating the effect of neonatal stroke in a new mouse model established by the Comi laboratory on endogenous neurogenesis in the neurogenic niches of the sub-granular and sub-ventricular zones in the central nervous system. Using the expertise gained during her pre-doctoral training in the Dudek Lab, she has established a mouse electroencephalogram (EEG) laboratory at the Kennedy Krieger Institute with capabilities of recording chronic and continuous EEGs. Dr. Kadam is interested in investigating epileptogenesis in animal models of developmental disabilities with the goal to test novel therapies. Her current research projects involve characterizing the acute electrographic seizures and investigating the evolution of refractoriness following ischemia in the neonatal period. She is also leading a study investigating the role of MeCP2 in epileptogenesis and activity dependent glutamate homeostasis in-vivo.

Research Publications

George S, Kadam SD, Irving ND, Markowitz GJ, Raja S, Kwan A, Tu Y, Chen H, Rohde C, Smith DR, Comi AM. (2013). Impact of trichostatin A and sodium valproate treatment on post-stroke neurogenesis and behavioral outcomes in immature mice. Frontiers in Cellular Neuroscience, 7, 123.

Kadam SD, Gucek M, Cole RN, Watkins PA, Comi AM. (2012). Cell proliferation and oxidative stress pathways are modified in fibroblasts from Sturge-Weber syndrome patients. Archives in Dermatological Research, 304(3), 229-235.

Markowitz GJ, Kadam SD, Smith DR, Johnston MV, Comi AM. (2011). Different effects of high- and low-dose phenobarbital on post-stroke seizure suppression and recovery in immature CD1 mice. Epilepsy Research, 94(3), 138-148.

Alberi L, Chi Z, Kadam SD, Mulholland JD, Dawson VL, Gaiano N, Comi AM. (2010). Neonatal stroke in mice causes long-term changes in neuronal Notch-2 expression that may contribute to prolonged injury. Stroke, 41(10 Supplement), S64-S71.

Markowitz GJ, Kadam SD, Boothe DM, Irving ND, Comi AM. (2010). The pharmacokinetics of commonly used antiepileptic drugs in immature CD1 mice. Neuroreport, 21(6), 452-456.

Kadam SD, Smith-Hicks CL, Smith DR, Worley PF, Comi AM.(2010). Functional integration of new neurons into hippocampal networks and poststroke comorbidities following neonatal stroke in mice. Epilepsy & Behavior, 18(4), 344-357.

Kadam SD, White AM, Staley KJ, Dudek FE.(2010). Continuous electroencephalographic monitoring with radio-telemetry in a rat model of perinatal hypoxia-ischemia reveals progressive post-stroke epilepsy. The Journal of Neuroscience, 30(1), 404-415.

Kadam SD, Mulholland JD, McDonald JW, Comi AM.(2009). Poststroke subgranular and rostral subventricular zone proliferation in a mouse model of neonatal stroke. Journal of Neuroscience Research, 87(12), 2653-2666.

Kadam SD, Mulholland JD, Smith DR, Johnston MV, Comi AM. (2009). Chronic brain injury and behavioral impairments in a mouse model of term neonatal strokes. Behavioural Brain Research, 197(1), 77-83.

Traa BS, Mulholland JD, Kadam SD, Johnston MV, Comi AM. (2008). Gabapentin neuroprotection and seizure suppression in immature mouse brain ischemia. Pediatric Research, 64(1), 81-85.

Kadam SD, Mulholland JD, McDonald JW, Comi AM. (2008). Neurogenesis and neuronal commitment following ischemia in a new mouse model for neonatal stroke. Brain Research, 1208, 35-45.

Kadam SD, Dudek FE. (2007). Neuropathogical features of a rat model for perinatal hypoxic-ischemic encephalopathy with associated epilepsy. The Journal of Comparative Neurology, 505(6), 716-737.

White AM, Williams PA, Ferraro DJ, Clark S, Kadam SD, Dudek FE, Staley KJ. (2006). Efficient unsupervised algorithms for the detection of seizures in continuous EEG recordings from rats after brain injury. Journal of Neuroscience Methods, 152(1-2), 255-266.