Description (from grant):
Neurodevelopmental processes are shaped by dynamic interactions between genes and environments. Maladaptive experiences early in life can alter developmental trajectories, leading to harmful and enduring developmental sequelae. Pre- and postnatal hazards include maternal substance exposure, toxicant exposures in pregnancy and early life, maternal health conditions, parental psychopathology, maltreatment, structural racism, and excessive stress. To elucidate how various environmental hazards impact child development, it is imperative that a normative template of developmental trajectories over the first 10 years of life be established based on a sufficiently large and demographically diverse sample of the US population. To accomplish this, the Healthy Brain and Child Development National Consortium (HBCD-NC) has been formed to deploy a harmonized, optimized, and innovative set of neuroimaging (MRI, EEG) measures complemented by an extensive battery of behavioral, physiological, and psychological tools, and biospecimens to understand neurodevelopmental trajectories in a sample of 7,500 mothers and their children from before birth to 10 years of age enrolled at 24 sites across the United States (US). The HBCD-NC will carry out a common research protocol under direction of the HBCD-NC Administrative Core (HCAC) and will assemble and distribute a comprehensive and well-curated research dataset to the scientific community at large under the direction of the HBCD-NC Data Coordinating Center (HDCC). The overarching goal of the HBCD-NC is to create a comprehensive, harmonized, and high- dimensional dataset that will characterize typical neurodevelopmental trajectories in US children and that will assess how biological and environmental exposures affect those trajectories. A special emphasis will be placed on understanding the impact of pre- and postnatal exposure to opioids, marijuana, alcohol, tobacco and/or other substances. To address these broad objectives, the sample of women enrolled will include: 1) a racially, ethnically, and socioeconomically diverse cohort that is representative of the US population; 2) pregnant women with use of targeted substances (opioids, marijuana, alcohol, tobacco); and 3) demographically and behaviorally similar women without substance use in pregnancy to enable valid causal inferences. In addition, the HBCD-NC will identify key developmental windows during which both harmful and protective environments have the most influence on later neurodevelopmental outcomes. The large, multi-modal, longitudinal, and generalizable dataset that will be produced for the first time by this study will provide novel insights into child development using state- of-the-art methods. The HBCD-NC study will inform public policy to improve the health and development of children across the nation.
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Dean DC 3rd, Tisdall MD, Wisnowski JL, Feczko E, Gagoski B, Alexander AL, Edden RAE, Gao W, Hendrickson TJ, Howell BR, Huang H, Humphreys KL, Riggins T, Sylvester CM, Weldon KB, Yacoub E, Ahtam B, Beck N, Banerjee S, Boroday S, Caprihan A, Caron B, Carpenter S, Chang Y, Chung AW, Cieslak M, Clarke WT, Dale A, Das S, Davies-Jenkins CW, Dufford AJ, Evans AC, Fesselier L, Ganji SK, Gilbert G, Graham AM, Gudmundson AT, Macgregor-Hannah M, Harms MP, Hilbert T, Hui SCN, Irfanoglu MO, Kecskemeti S, Kober T, Kuperman JM, Lamichhane B, Landman BA, Lecour-Bourcher X, Lee EG, Li X, MacIntyre L, Madjar C, Manhard MK, Mayer AR, Mehta K, Moore LA, Murali-Manohar S, Navarro C, Nebel MB, Newman SD, Newton AT, Noeske R, Norton ES, Oeltzschner G, Ongaro-Carcy R, Ou X, Ouyang M, Parrish TB, Pekar JJ, Pengo T, Pierpaoli C, Poldrack RA, Rajagopalan V, Rettmann DW, Rioux P, Rosenberg JT, Salo T, Satterthwaite TD, Scott LS, Shin E, Simegn G, Simmons WK, Song Y, Tikalsky BJ, Tkach J, van Zijl PCM, Vannest J, Versluis M, Zhao Y, Zöllner HJ, Fair DA, Smyser CD, Elison JT; HBCD MRI Working Group. Quantifying brain development in the HEALthy Brain and Child Development (HBCD) Study: The magnetic resonance imaging and spectroscopy protocol. Dev Cogn Neurosci. 2024 Dec;70:101452. PMCID: PMC11466640.