Intellectual Developmental Disabilities Research Center (IDDRC)

Installation of 7.0 Tesla MRI Core
Expanding infrastructure: 7T MRI installation

7.0 Tesla MRI Core being installed in the F. M. Kirby Center for Neuroimaging in the new Clinical Research Building at Kennedy Krieger Institute
Illustration of white matter pathways in human brain
Developing options for analysis of MRI data

Visualizing MRI data using various criteria for studies of brain anatomy, vascular territories, and connectivity
Mouse Models of Developmental Disorders
Studying mouse models of developmental disorders

Mouse models of developmental disorders are providing insights into underlying mechanisms of atypical brain structure and functioning
Mice Axons
Cutting edge microscopy includes antibody staining

Immunocytochemical staining of serotoninergic axons: Barrel field cortex and hippocampus of GAP-43 knockout mice (C & D) compared to controls (A & B)

The Intellectual and Developmental Disabilities Research Center (IDDRC) at Kennedy Krieger Institute and The Johns Hopkins University School of Medicine supports research to help children, adolescents, and adults with developmental disorders and injuries achieve their potential and participate as fully as possible in family, school, work, and community life. The Center has been central to a scientific enterprise involving hundreds of investigators working to understand and address the problems of developmental disabilities. Since 1987, the IDDRC has been the nucleus of a larger program of research supported through the Hugo Moser Research Institute established within Kennedy Krieger Institute, in collaboration with affiliated programs throughout The Hopkins’s academic community. The strengths of this community provide enormous opportunities for translational research relevant to developmental disorders, with internationally recognized expertise and infrastructure well-suited to the task of moving knowledge along the continuum from “bench-to-community.” 

This is a particularly exciting time to be a scientist in the field of developmental disabilities, with powerful new technologies now available for advancing the understanding of the interaction and contribution of genetics and environmental influences on typical and atypical brain development and functioning. The IDDRC has supported cutting-edge science through provision of Core support to over 350 projects and investigators resulting in over 2,000 published scientific studies. This work has contributed in numerous ways to positively impact the lives of people with developmental disabilities and their families.

The IDDRC has grown steadily since 1987  and now supports scientists throughout the Kennedy Krieger/Johns Hopkins community in the areas of neuroscience, genetics, neuroimaging, and behavior science. Ours is one of only 15 IDDRCs in the United States supported by the Eunice Kennedy Shriver National Institute on Child Health and Human Development. Our partnerships with neighboring IDDRCs at the Children’s Hospital of Philadelphia and Children’s National Medical Center in Washington, D.C. have become especially strong in recent years, and we are particularly well positioned for studies of rarer conditions causing developmental disabilities. For the future, we are looking forward to not only the support of outstanding research within our own Institutions, but also the development of cross-Center projects involving both this Mid-Atlantic Consortium and the broader IDDRC network.