HUGO MOSER RESEARCH INSTITUTE OVERVIEW

Kennedy Krieger’s scientists and researchers are leaders in the worldwide effort to prevent and treat disorders of the brain, spinal cord, and musculoskeletal system.  Our investigators continue to break new ground with innovative magnetic resonance imaging technology, investigate critical areas, such as the role of genetics in developmental disorders, and develop new treatment models and therapies. Kennedy Krieger is committed to sharing our knowledge that can be adapted and used by other healthcare organizations to benefit patients across the country and around the world.

Learn more about the Hugo Moser Research Institute's innovative research initiatives and latest findings:

Research Frontiers      Research Updates

Professional Training Overview

Kennedy Krieger dedicates substantial resources to increasing the number of qualified specialists in the fields of neurological and developmental disabilities. We also take seriously our responsibility not only to improve care through research, but to share that knowledge with others. That is why more than 400 individuals come here to train in a wide variety of disciplines each year. The goals of the Institute’s clinical training programs are twofold: 1) to train leaders in the field of neurodevelopmental disabilities and 2) to help ensure that there is a sufficient number of qualified professionals to meet the needs of children with special health care needs and their families. By training future generations of researchers and professionals – from undergraduate students to current staff – we are ensuring that children everywhere can receive the best possible care.

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A National Research Resource Center for Functional Brain Imaging Technology

The only children's hospital designated as a NIH National Research Resource for functional brain imaging, Kennedy Krieger is breaking new ground with innovative fMRI technology.
Understanding Behaviors Through Observational Research

Discovering the environmental and biological basis of behavior is crucial to understanding and improving treatment outcomes for a wide variety of developmental disorders.
Motion Analysis Research and Laboratory

Using 3D modeling and other innovative technologies, our researchers are studying new methods to improve walking patterns in those with brain injuries.
IAN Research: Advancing Research, Empowering Advocates, Interpreting Findings

The Interactive Autism Network (IAN) is the nation's largest online autism research effort. IAN Research collects data from families online and matches them to studies nationwide.

HUGO MOSER RESEARCH INSTITUTE OVERVIEW

Kennedy Krieger’s scientists and researchers are leaders in the worldwide effort to prevent and treat disorders of the brain, spinal cord, and musculoskeletal system.  Our investigators continue to break new ground with innovative magnetic resonance imaging technology, investigate critical areas, such as the role of genetics in developmental disorders, and develop new treatment models and therapies. Kennedy Krieger is committed to sharing our knowledge that can be adapted and used by other healthcare organizations to benefit patients across the country and around the world.

Learn more about the Hugo Moser Research Institute's innovative research initiatives and latest findings:

Research Frontiers      Research Updates

Participate in Research

Over the years, Kennedy Krieger’s scientists and researchers have made crucial medical discoveries that have led to innovative treatments and improved patient care for individuals with disorders of the brain, spinal cord and musculoskeletal system. Learn more about current research studies you can participate in by visiting our recruiting research studies page. View studies
 
CLINICAL TRIALS STUDIES
 
The Clinical Trials Unit at Kennedy Krieger Institute brings together patients and families, research scientists and private industry to unlock the potential of new treatments to treat, cure and prevent genetic and developmental disorders. Learn more

Current Research Projects

Quantitative mapping of the basal ganglia and related structures in children with dyskinetic cerebral palsy
Principal Investigator: Hoon, Alexander
Cerebral palsy (CP) refers to a group of motor-impairment syndromes secondary to genetic and acquired disorders of early brain development.  When the underlying disorder affects the basal...
Neurotrophin Protection of Hypoxic Ischemic Brain Injury
Principal Investigator: Hossain, Mir Ahamed
Perinatal hypoxia-ischemia (HI) is a major cause of life-long neurological disability such as cerebral palsy. There are few treatments available for this devastating disorder. For the next period of...
Functional and Neurovascular Biomarkers for Huntington’s disease using MRI at 7T
Principal Investigator: Hua, Jun
Oxidative stress and metabolic disturbances in the brain are believed to be involved in HD pathogenesis. Functional and neurovascular brain changes may represent altered neuronal physiology and...
Research Training in Rehabilitation for Brain Injury and Neurological Disability
Principal Investigator: Johnston, Michael
This is the first resubmission of an application for renewal of an Institutional National Research Service Award for a successful postdoctoral training program in medical rehabilitation research that...
Cholesterol Homeostasis in Malignant Glioma
Principal Investigator: Kolar, Elizabeth
The Watkins Lab has observed that when U87 human malignant glioma cells are deficient for a particular acyl- CoA synthetase, ACSVL3, the cells had significantly lower cholesterol levels than did wild...
Multisite RCT of Early Intervention for Spoken Communication in Autism
Principal Investigator: Landa, Rebecca
While significant progress has been made toward identifying effective interventions for preschool-age children with autism (National Research Council, 2001), few scientifically rigorous studies have...
Autism: Social and Communication Predictors in Siblings
Principal Investigator: Landa, Rebecca
This is a longitudinal study of Autism Spectrum Disorders (ASD). Six groups will be assessed longitudinally. Group 1: siblings of probands with autism; (Group 2) late talkers having no family history...
MCH Research - Parent-Mediated Vs. Center-Based Intervention for Toddlers with ASD: An RCT
Principal Investigator: Landa, Rebecca
An ever increasing number of toddlers are identified as being at high risk for ASD. This translates into an increasing demand for Part C Early Intervention services. The importance of intervention...
Effects of Self-Generated Experiences on Social Cognitive Development in Young Children with Autism
Principal Investigator: Landa, Rebecca
Sponsored by Autism Speaks -- 7746. This study will test whether a novel treatment for social impairment in young children with autism spectrum disorders (ASD) leads to improvement at behavioral and...
Development of a Social and Communication Intervention for Preschoolers with Autism
Principal Investigator: Landa, Rebecca
RFA topic and goal:  Autism Spectrum Disorders, Development and Innovation Goal Two Purpose:  Develop and document feasibility and promise of a social and communication curriculum, and...
Suppression of Glioblastoma Stem Cells by Kruppel-Like Factor 9
Principal Investigator: Laterra, John
Glioblastoma stem-like cells (or cancer stem cells, CSCs) maintain a capacity for multi-lineage differentiation and efficiently propagate tumor xenografts that accurately recapitulate the complex...
Brain Cancer Stem Cell Reprogramming by C-MET
Principal Investigator: Laterra, John
Glioblastoma (GBM) is an almost universally fatal brain tumor with an average median survival of only ~15 months. New effective therapies are desperately needed. Small subpopulations of malignant...
Neuroimaging, Behavior, and Biochemical Correlates in Smith-Lemli-Opitz Syndrome (SLOS)
Principal Investigator: Lee, Ryan
SLOS is an autosomal recessive, multiple malformation syndrome of impaired cholesterol biosynthesis resulting in decreased cholesterol and elevated concentrations of abnormal sterols in tissues and...
Magnetic Resonance Imaging and Spectroscopy Biomarkers for Facioscapulohumeral Muscular Dystrophy
Principal Investigator: Leung, Doris
This study, supported by the FSH Society, will utilize magnetic resonance imaging (MRI) and magnetic resonance spectroscopy (MRS) to develop non-invasive, quantitative imaging biomarkers for...
Interactive Autism Network Project
Principal Investigator: Lipkin, Paul
The Interactive Autism Network (IAN) was established in 2006 to accelerate autism spectrum disorder (ASD) related research by creating a national online registry and longitudinal research...
Interactive Autism Network Research Database
Principal Investigator: Lipkin, Paul
The proposed project will enable the Interactive Autism Network (IAN) to provide recruitment assistance to qualified research projects throughout the U.S. and to provide a large, validated...
Monitoring Prodrug Delivery in Suicide Gene Therapy Using CEST MRI
Principal Investigator: Liu, Guanshu
To accelerate the development of nanotechnologies for drug and gene delivery, it is highly desired to construct nanoparticles with imaging capabilities so that the process of delivery and release can...
Development of ADHD in Preschool Children: Neuroimaging and Behavioral Correlates
Principal Investigator: Mahone, E. Mark
Attention-Deficit/Hyperactivity Disorder (ADHD) has become the most commonly diagnosed form of psychopathology in the preschool years. To address this alarming trend, the overall goal of the proposed...
Optic Nerve Head Synucleinopathy in Glaucoma and Function of Gamma-Synuclein
Principal Investigator: Marsh-Armstrong, Nicholas
The broad long-term goal of this application is to uncover the mechanism of retinal ganglion cell (RGC) degeneration in glaucoma so as to be able to design rational therapeutic interventions based on...
Transcellular Degradation of Mitochondria in the Central Nervous System
Principal Investigator: Marsh-Armstrong, Nicholas
We recently made the surprising discovery that mitochondria from retinal ganglion cell axons are passed onto neighboring astrocytes for degradation in the optic nerve head of normal mice. We present...
Developing New Multicolor Polypeptide MR Contrast Agents for Stem Cell Tracking
Principal Investigator: McMahon, Michael
Development of new contrast materials is important to expand the diagnostic capabilities of MR at the cellular and molecular level. In particular, providing information on cell migration, trafficking...
Multi-Color Exchange Transfer Imaging of Drug Delivery Nanocarriers
Principal Investigator: McMahon, Michael
This project focuses on the design of biodegradable contrast agents, based on peptides and heterocycles, to be used for the labeling of drug delivery vehicles such as liposomes and polymeric...
OIACEST Islet Cell Capsules for Immunoprotection, MR Detection, and pH Sending
Principal Investigator: McMahon, Michael
Good glycemic control is critical in reducing the end-stage complications of Type I Diabetes Mellitus (TIDM) and, for this reason, islet transplantation (ITx) has received considerable attention in...
Anomalus Motor Physiology in ADHD
Principal Investigator: Mostofsky, Stewart
The hypothesis of this study is that the neuromotor anomalies present in children with ADHD will be associated with deficient intracortical and interhemispheric inhibition of the motor cortex. This...
Neurology of Deficient Response Control in ADHD
Principal Investigator: Mostofsky, Stewart
Building on evidence established in the initial grant period, the overall goals of the proposed study, “Neurology of Deficient Response Control in ADHD,” are to apply advanced neuroimaging and...
Electrophysiological Studies of Autism
Principal Investigator: Ewen, Joshua
Abnormalities of cortical connectivity have long been suspected to be responsible, at least in part, for the autism phenotype. Research to date has used a number of modalities, but none has the time...
Studies of the Link between Autism and Epilepsy
Principal Investigator: Ewen, Joshua
This research consists of a retrospective record review to examine the link between autism, epilepsy and other clinical symptoms (including, but not limited to, intellectual disability, motor...
Masqueraders of Cerebral Palsy
Principal Investigator: Fatemi, S. Ali
Genetic conditions that manifest movement and postural impairment at perinatal or early childhood periods are often diagnosed with cerebral palsy. Identifying masqueraders of cerebral palsy...
Patient attitudes toward informed consent regarding incidental findings in whole exome sequencing
Principal Investigator: Fatemi, S. Ali
The objective of this study is to assess the association between school-based transition planning and health care transition planning for youth with special healthcare needs (YSHCN). The 2011...
Genetic Causes of Intellectual Disability
Principal Investigator: Fatemi, S. Ali
The purpose of this study is to define the biochemical and genetic basis of peroxisomal disorders and to develop new methods for prevention and treatment. The study obtains samples of blood or skin...
ALD Connect
Principal Investigator: Fatemi, S. Ali
Adrenoleukodystrophy (ALD) is an X-linked disorder with several phenotypes ranging from childhood to adulthood. The objective of ALD Connect is to create a patient-centered clinical research network...
12708A: An open-label study evaluating the Pharmacokinetics and Tolerability of Lu AA21004 in connection with multiple oral dosing of Lu AA21004 in child and adolescent patients with a DSM-IV-TR(TM) diagnosis of Depressive or Anxiety Disorder
Principal Investigator: Findling, Robert
This open-label study will evaluate the pharmacokinetic, tolerability and safety profiles of Lu AA21004 in connection with a multiple oral dosing in child and adolescent patients with a DSM-IV-TR...
A0501093: SPRITES: SERTRALINE PEDIATRIC REGISTRY FOR THE EVALUATION OF SAFETY: A Non-Interventional, Longitudinal, Cohort Study to Evaluate the Effects of Long-Term Sertraline Treatment in Children and Adolescents
Principal Investigator: Findling, Robert
The primary objectives are to evaluate the long-term impact of treatment with sertraline on aspects of cognition, emotional and physical development, and pubertal maturation. Secondary objectives...
A Multi-Center, Randomized, Double-Blind, 12-Week, Parallel Group, Placebo-Controlled Proof of Concept Study to Investigate the Efficacy and Safety of RO5285119 in Individuals with Autism Spectrum Disorders (ASD)
Principal Investigator: Findling, Robert
The main objective of this study is to evaluate the efficacy of 12-week treatment with RO5258119 compared with placebo in treating social communication deficits in adult individuals with ASD as...
VLZ-MD-21: A Double-Blind, Placebo-Controlled Evaluation of the Safety and Efficacy of Vilazodone in Adolescent Patients with Major Depressive Disorder
Principal Investigator: Findling, Robert
Purpose This is a double-blind, randomized, placebo-controlled, fixed-dose trial designed to evaluate the efficacy, safety, and tolerability of vilazodone for the treatment of major depressive...
A Randomized, Placebo-Controlled Study to Investigate the Efficacy and Safety of Circadin® to Alleviate Sleep Disturbances in Children with Neurodevelopmental Disabilities
Principal Investigator: Findling, Robert
The purpose of this study is to establish the efficacy and safety of Circadin in children with neurodevelopmental disorders and to determine the dose, this randomized, placebo-controlled study is...
D1050302: A 104-week, flexible-dose, open-label, multicenter, extension study to evaluate the long-term safety and effectiveness of Lurasidone in pediatric subjects with schizophrenia and subjects with irritability associated with autistic disorder
Principal Investigator: Findling, Robert
This open-label extension study is designed to evaluate the safety, tolerability, and effectiveness of lurasidone for the treatment irritability in individuals with autistic disorder. As an extension...
A Phase 3, multicenter, three-week, randomized, double-blind, placebo-controlled, parallel-group efficacy and safety trial of flexible doses of oral Ziprasidone in children and adolescents with Bipolar I disorder (current or most recent episode manic)
Principal Investigator: Findling, Robert
This will be a Phase 3, multicenter, 3-week, randomized, double-blind, placebo-controlled, parallel-group trial to evaluate the efficacy, safety, and tolerability of flexibly dosed ziprasidone...
An adaptive, phase IIB/III, double-blind, randomized, placebo-controlled, multi-center study of the safety and efficacy of NaBen® (sodium benzoate), a d-amino acid oxidase inhibitor, as an add-on treatment for schizophrenia in adolescents
Principal Investigator: Findling, Robert
Phase IIb Objectives: The primary objective of the Phase IIb portion of this study is to evaluate NaBen® (sodium benzoate) (1000 mg/day) safety and effectiveness and to determine the final sample...
Validation Study of the Aggression Diary
Principal Investigator: Findling, Robert
The primary objective of this study is to conduct psychometric tests on the electronic observer- reported (eObsRO) Aggression Diary to evaluate whether the diary is a valid and reliable measure for...
A Randomized, 6-Week, Double-Blind, Placebo-Controlled, Flexible Dose, Parallel-Group Study To Evaluate The Efficacy And Safety Of Lurasidone In Children And Adolescent Subjects With Bipolar I Depression
Principal Investigator: Findling, Robert
To evaluate the efficacy of lurasidone (20 - 80 mg/day flexibly dosed) compared with placebo in children and adolescent subjects with bipolar I disorder, most recent episode depressed, with or...
A Phase Ill, Randomized, Double-Blind, Placebo­ Controlled, Parallel-Arm, Multi-Center Study Measuring the Efficacy and Safety of Prc-063 in Adolescent ADHD Patients
Principal Investigator: Findling, Robert
This is a parallel, randomized, double-blind, forced-dose titration, multicenter, placebo­ controlled, phase 3 study to evaluate the safety and efficacy of PRC-063 (methylphenidate hydrochloride...
A 6-Week, Randomized, Multicenter, Double-Blind, Parallel, Flexed- and Fixed-Dose Study Of Mg01ci (Metadoxine Extended-Release) 700 Mg and 1400 Mg Compared With Placebo in Adults and Adolescents With Fragile X Syndrome
Principal Investigator: Findling, Robert
The study medication, MG01CI (Metadoxine Immediate-release/Slow-release Bilayer Tablet), is being investigated for the treatment of Fragile X Syndrome (FXS) in adults and adolescents. The purpose of...
A Phase 1, Multicenter, Open-label, Dose-Escalation Trial to Assess the Safety, Tolerability and Pharmacokinetics of Oral Brexpiprazole (OPC-34712) in Adolescents with Schizophrenia
Principal Investigator: Findling, Robert
This is a phase 1, multicenter, open-label, dose-escalation trial in adolescent subjects (age 13 to 17 years) with a diagnosis of schizophrenia. This trial consists of a screening period (3 to 42...
A Phase 3, 12-Month, Multicenter, Open-label, Flexibly-dosed, Safety Study of SEP-225289 in Adults with Attention Deficit Hyperactivity Disorder (ADHD)
Principal Investigator: Findling, Robert
To evaluate the long-term safety and tolerability of SEP-225289 in adult subjects with ADHD by the incidence of adverse events (AEs; or serious AEs), AEs (or SAEs) leading to discontinuation.
A 6-Month Study to Evaluate the Safety, Tolerability and Efficacy of Desvenlafaxine Succinate Sustained-Release (Dvs Sr) Tablets in the Treatment of Children and Adolescent Outpatients with Major Depressive Disorder
Principal Investigator: Findling, Robert
A 6-Month, Open-Label, Multi-Center, Flexible-Dose Extension Study to the B2061032 Study to Evaluate the Safety, Tolerability and Efficacy of Desvenlafaxine Succinate Sustained-Release (Dvs Sr)...
A Multicenter, Parallel-Group Study to Evaluate the Efficacy, Safety and Tolerability of Desvenlafaxine Succinate Sustained-Release (Dvs Sr) in the Treatment of Children and Adolescent Outpatients with Major Depressive Disorder
Principal Investigator: Findling, Robert
A Multicenter, Randomized, Double-Blind, Placebo-Controlled, Parallel-Group Study to Evaluate the Efficacy, Safety and Tolerability of Desvenlafaxine Succinate Sustained-Release (Dvs Sr) in the...
A Randomized, Double-Blind, Multicenter, Placebo-controlled, Parallel-group, Efficacy and Safety Study of 2 Doses of Dasotraline in Adults with Attention Deficit Hyperactivity Disorder (ADHD)
Principal Investigator: Findling, Robert
To evaluate the efficacy and safety of dasotraline (4mg/day and 6 mg/day) compared with placebo in adult subjects with ADHD as measured by change from baseline at Week 8 in ADHD symptoms assessed...
A Multicenter, Double-blind, Placebo- and Active-Controlled Parallel-Group Evaluation of the Safety and Efficacy of Vilazodone in Pediatric Patients With Major Depressive Disorder
Principal Investigator: Findling, Robert
The objective of this study is to evaluate the efficacy, safety, and tolerability of vilazodone compared with placebo in pediatric outpatients (7-17 years of age) with MDD. In addition, the study is...
Interventional, Randomized, Double-Blind, Placebo-Controlled, Fixed-Dose Study of Vortioxetine in Adults with Attention Deficit Hyperactivity Disorder (ADHD)
Principal Investigator: Findling, Robert
Primary Objective: To evaluate the efficacy of vortioxetine 10 mg/day and 20 mg/day versus placebo on ADHD symptoms in the treatment of adult patients with a DSM-5™ diagnosis of ADHD. Secondary...
A Phase 2, Exploratory Safety, Tolerability, Pharmacokinetic, and Efficacy Study of SPD489 in Preschool Children Aged 4-5 Years with Attention-Deficit/Hyperactivity Disorder (ADHD)
Principal Investigator: Findling, Robert
A Phase 2, Open-label, Multicenter, Exploratory Safety, Tolerability, Pharmacokinetic, and Efficacy Study of SPD489 in Preschool Children Aged 4-5 Years with Attention-Deficit/Hyperactivity Disorder...
A Randomized, Double-Blind, Placebo-Controlled, Parallel-Group, Fixed Dose Study of Nnz-2566 in Fragile X Syndrome
Principal Investigator: Findling, Robert
The purpose of this study is to look at the safety of NNZ-2566 for adolescents and adults with Fragile X Syndrome and to determine the drug properties (pharmacokinetic) of NNZ-2566 in people with...
A Multi-Country Analysis of Patients with Chronic Myeloid Leukemia
Principal Investigator: Gary, Devin
This application is based on a study that was originally carried out and completed at George Washington University. All of the data for this study has been collected. No new data will be collected at...
Studies of Hormone Action in Patients with Altered G-protein-coupled Signal Transduction
Principal Investigator: Germain-Lee, Emily
Includes Substudies Entitled: "Study of Growth Hormone Secretion in Patients with Pseudohypoparathyroidism Type 1a (R01 FD002568)" and "Phase 2 Growth Hormone for Treatment of Albright Hereditary...
Retrospective Chart Review of Growth in Osteogenesis Imperfecta
Principal Investigator: Germain-Lee, Emily
The purpose of this research is to assess the growth parameters(height and weight) in osteogenesis imperfecta during infancy, childhood, and adolescence with the ultimate goal of determining whether...
Predictive Value of Perinatal Biomarkers Following Very Preterm Birth for Cerebral Palsy and Developmental Delay at Age 24 Months
Principal Investigator: Gerner, Gwendolyn
Neurologic injury identified in neonates soon after pre-term birth may either completely resolve or lead to life-long disabilities, including cerebral palsy (CP), that are a severe burden for these...
Rapalogues for Autism Phenotype in TSC: A Feasibility Study
Principal Investigator: Gipson, Tanjala
Tuberous sclerosis complex (TSC) is associated with autism and seizures. Recent studies in animals using rapamycin have shown cognitive improvement. Human studies have demonstrated a reduction in...
CRAD001M2304: A three-arm, randomized, double-blind, placebo-controlled study of the efficacy and safety of two trough-ranges of everolimus as adjunctive therapy in patients with tuberous sclerosis complex (TSC) who have refractory partial-onset seizures
Principal Investigator: Gipson, Tanjala
This study will investigate the efficacy and safety of everolimus, as adjunctive treatment, in patients ages 2-65 years with Tuberous Sclerosis Complex (TSC) that have refractory partial-onset...
Features of Self-Injury in TSC
Principal Investigator: Gipson, Tanjala
Our objective in this study is to look at the feasibility of collecting de-identified data on the topography, severity, and frequency of disruptive behaviors in TSC using an on-line survey.
Rapamycin for Autism Phenotype & seizures in Tuberous Sclerosis (RAPS)
Principal Investigator: Gipson, Tanjala
Tuberous sclerosis complex (TSC) is associated with autism and seizures. Recent studies in animals using rapamycin have shown cognitive improvement. Human studies have demonstrated a reduction in...
Interdisciplinary Protocol for Patients with TSC
Principal Investigator: Gipson, Tanjala
The major features of Tuberous Sclerosis Complex (TSC) are abnormalities of the brain –cortical tubers, subependymal nodules and subependymal giant cell astrocytomas; skin –hypomelanotic macules,...
Reward System in Autism
Principal Investigator: Goldberg, Melissa
It is a core feature of autism that social interactions appear to be far less rewarding for autistic children compared to typically developing children. Based on this observation, one would predict...
Program evaluation of caregivers' behavioral workshop
Principal Investigator: Gonzalez, Melissa
The Pediatric Feeding Disorders Program at Kennedy Krieger Institute provides services aimed at establishing appropriate feeding responses for children who present with a variety of feeding...
An evaluation of differential reinforcement on appropriate toy skills
Principal Investigator: Gonzalez, Melissa
The purpose of the current study will be to increase the play skills for six children with developmental disabilities, who display limited interest in toys in a free operant setting. It is...
Evaluation of Assessment and Treatment Data in Individuals with Intellectual/Developmental Disabilities
Principal Investigator: Hagopian, Louis
The purpose of this retrospective record review is to develop a database to evaluate the efficacy and efficiency of behavior analytic procedures in assessing and treating severe problem behavior.
Behavioral Economics in MR/DD and Behavior Disorders (2)
Principal Investigator: Hagopian, Louis
Assessments of severe behavior disorders of children with intellectual and developmental disabilities (IDD) have revealed that behavior problems are often maintained by their functional outcomes (or...
Delineating subtypes of self-injurious behavior maintained by automatic reinforcement
Principal Investigator: Hagopian, Louis
Self-injurious behavior (SIB) is one of the most serious problems experienced by individuals with intellectual disabilities. The standard of care for the assessment of SIB involves conducting a "...
Translational Analyses of Chronic Aberrant Behavior Across the Lifespan
Principal Investigator: Hagopian, Louis
The goal of the proposed line of research is to gain a better understanding of the processes that evoke and maintain severe problem behavior (i.e., chronic aberrant behavior) in persons with...
Pediatric Psychology Consultation-Liaison Services: A Review of Clinical Practice and Patterns
Principal Investigator: Hendricks, Melissa
Pediatric psychology consultation-liaison (CL) service is the most active form of collaboration between pediatric psychologists and health care specialists. The proposed study is a combination of...
Interrelationships among quantitative measures of white matter injury, sensorimotor function and learning profiles in children with cerebral palsy
Principal Investigator: Hoon, Alexander
Injury to white matter pathways is strongly associated with the severity of spastic diplegia in children born preterm. In previous research, we have shown that there is preferential injury in sensory...
Quantitative mapping of the basal ganglia and related structures in children with dyskinetic cerebral palsy
Principal Investigator: Hoon, Alexander
Cerebral palsy (CP) refers to a group of motor-impairment syndromes secondary to genetic and acquired disorders of early brain development.  When the underlying disorder affects the basal...
Parental Feedback on the Phelps Center Visual Diagram
Principal Investigator: Hoon, Alexander
The purpose of this research study is to collect parental feedback on a clinic-developed visual diagram utilized by Dr. Alec Hoon at the Phelps Center for Cerebral Palsy and Developmental Medicine at...
Evaluation and Development of the IIAM (Important Information About Me) iPad App
Principal Investigator: Hoon, Alexander
In 2011 a multidisciplinary group at Kennedy Krieger Institute and Johns Hopkins created IIAM (Important Information About Me) as a "voice" for those who cannot "speak”.IIAM is an innovative and...
IIAM (Important Information About Me): The Ongoing Development of A Novel iPad App
Principal Investigator: Hoon, Alexander
In 2011 a multidisciplinary group at Kennedy Krieger Institute and Johns Hopkins created IIAM (Important Information About Me) as a "voice" for those who cannot "speak”. IIAM is an innovative and...
Comparison of Executive and Adaptive Skills in Individuals Diagnosed with Brain Tumor versus ADHD
Principal Investigator: Jacobson, Lisa
Neuropsychological assessment and screening is a useful means of identifying cognitive deficits in children and adolescents. Expansion of availability of instruments has now permitted an examination...
Psychotropic Medication Use at The Family Center: A 4-Year Analysis
Principal Investigator: Jamora, Mariflor
There have been recent concerns about excessive and inappropriate use of psychotropic medication in foster children, sparked by the recent GAO (Government Accountability Office) report in 2011....
Clinical Trials Center Intake, Registry and Questionnaire Database Project
Principal Investigator: Johnston, Michael
The Objectives of this protocol are: a. To create a standard intake process for individuals interested in possible participation in clinical trials at the Clinical Trials Unit (CTU), as well as to...
Student-Centered Behavioral Interventions to Reduce Challenging Behavior in the Classroom
Principal Investigator: Kahng, SungWoo
Aggressive behavior in young children is a known risk factor for youth violence (CDC, 2011). New methods for preventing youth violence and juvenile delinquency are needed to address this growing...
X-Linked Dominant Conradi-Hünermann Syndrome: Clinical and Biochemical Phenotype in Affected Males
Principal Investigator: Kratz, Lisa
X-Linked Dominant Conradi-Hünermann Syndrome (CPDX2) is a rare disorder of cholesterol biosynthesis caused by a deficiency of 3beta-hydroxysteroid-8, 7-isomerase (sterol isomerase), an enzyme encoded...
First Trimester Diagnosis of Smith-Lemli-Opitz Syndrome
Principal Investigator: Kratz, Lisa
Is sterol analysis of direct chorionic villus material or amniotic fluid an accurate method for first trimester diagnosis of Smith-Lemli-Opitz syndrome?

Faculty & Research Scientists