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Mechanisms of Locomotor Recovery in Multiple Sclerosis

Principal Investigator:
Kathleen
Zackowski

The study will test the general hypothesis that, in multiple sclerosis (MS) and following an acute exacerbation, damage of cerebellar white matter tracts (i.e. cerebellar peduncles) will show greater gait ataxia and worse recovery of walking compared to people with damage to motor cortex tracts (i.e. corticospinal pathway).

The proposed study will investigate:

1) whether specific white matter tract abnormalities that occur following an acute exacerbation of MS correlate with specific sensorimotor deficits and locomotor function, and
2) whether damage to specific white matter tracts (i.e., the corticospinal, dorsal column medial lemniscal and cerebellar tracts) can predict the recovery of locomotion after a relapse of MS.

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