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Funded Research Projects

Understanding the Brain Basis of Impaired Imitation Learning in Autism
Principal Investigator:
Nebel, Mary Beth
In a developmental disorder such as autism (ASD), brain-based learning mechanisms vital to the acquisition of motor skills may contribute to impaired development of social and communicative abilities...
The Role of the Transcallosal Pathway in Neuroplasticity Following Nerve Injury
Principal Investigator:
Pelled, Galit
Peripheral nerve injury causes sensory dysfunctions that are thought to be attributable not only to the functional, cellular and biochemical events occurring in the peripheral nerve, but also to the...
Adaptive Control of Epileptic Seizures Using A Genetically Encoded Sensor
Principal Investigator:
Pelled, Galit
Sponsored by the National Institutes of Health (NIH) -- 1R01NS079288-01. About 35 percent of epileptic patients do not respond to antiepileptic drugs. Of these, only a quarter of them can be treated...
Accommodations for ADHD: Are They Effective in Reducing the Impact of the Disorder?
Principal Investigator:
Pritchard, Alison
One of the most important functions served by a pediatric neuropsychological assessment is the provision of evidence-based recommendations and resources designed to reduce symptoms and improve...
MRI-based Quantitative Brain Perfusion Mapping for Sickle Cell Disease
Principal Investigator:
Qin, Qin
SCD is a genetic blood disorder characterized by abnormal hemoglobin S (HbS) synthesis with sickle cell anemia (SCA) as the most common subtype. Stroke is the most frequent cause of death and long-...
Pediatric Psychology and Neuropsychology Predoctoral Internship Training - Abstract
Principal Investigator:
Reeseman, Jennifer
Hearing loss or deafness affects more than 48.1 million individuals in the United States, with nearly 1 in 5 Americans displaying a hearing loss as defined by the World Health Organization criteria (...
ArmAware: A Novel Device to Treat Motor Disorders
Principal Investigator:
Salorio, Cynthia
The goal of this project is to develop a prototype of a novel device to treat hemiplegia. The award covers development costs of the initial prototypes.
Characterization of Biochemical Abnormalities Underlying Mitochondrial Dysfunction and Cardiomyopathy in Barth Syndrome and Adenine Nucleotide Translocase 1 (ANT-1) Deficiency
Principal Investigator:
Sandlers, Yana
The treatment of many inborn errors of metabolism is centered on recognizing and correcting, or compensating for metabolic aberrations. The limited understanding of the complexity of the biochemical...
The IBMD-OI Study: A Study to Assess the Effectiveness of Teriparatide (FORTEO)
Principal Investigator:
Shapiro, Jay
Sponsored by Eli Lilly and Company, the primary aim of this study is to assess whether an increase in BMD will result from the use of rhPTH. Furthermore, PTH has been shown to have effects on bone...
Treatment of Osteoporosis in Murine Rett Syndrome Models
Principal Investigator:
Shapiro, Jay
Sponsored by the International Rett Syndrome Foundation. At the Kennedy Krieger Institute, approximately 50 percent of young children and adults with Rett syndrome (RTT) have osteoporosis; 11...
Nutrition and Its Impact on Bone Growth in Children with Osteogenesis Imperfecta
Principal Investigator:
Shapiro, Jay
Sponsored by the Edward & Stella Van Houten Memorial Fund To provide information that may directly translate into improved care for children with OI and open the subject of nutrition as related...
Kennedy Krieger Institute's Linked Clinical Research Center in Osteogenesis Imperfecta
Principal Investigator:
Shapiro, Jay
As a participant of the Linked Clinical Research Centers (LCRC), the Osteogenesis Imperfecta (or) Program at the Kennedy Krieger Institute (KKI) brings an established record of multidiscliplinary...
Aging and Dementia in Adults with Down Syndrome
Principal Investigator:
Silverman, Wayne
This ongoing NIH supported Program Project will be renewed for another five years, and is programmatically a seamless continuation of my current Exempt protocol (#NA_00002225; "Changes in Functioning...
Pilot Treatment of the PEX1-G844D Mouse with Diosmetin
Principal Investigator:
Steinberg, Steven
We created the Pex1-G844D mouse to model the clinical phenotype found in humans associated with homozygosity for the equivalent PEX1 mutation, PEX1-G843D.  The Pex1-G844D mouse model...
Biomarkers of mild traumatic brain injury in children: predicting outcome and understanding recovery
Principal Investigator:
Suskauer, Stacy
Scientific Abstract: Current management of childhood mild TBI (mTBI, also known as concussion) is symptombased. Symptoms may last from hours to years, yet we lack objective biomarkers with which to...
Neural Basis of Recovery of Inhibitory Control After Pediatric TBI
Principal Investigator:
Suskauer, Stacy
Sponsored by NIH/NICHD - 5 K23 HD061611 Inhibitory control is frequently impaired following pediatric traumatic brain injury (TBI), and deficits in inhibitory control impact a child's function in...
Somatosensory Processing-Assessing Youth Sports-Related Concussion and Recovery
Principal Investigator:
Suskauer, Stacy
Youth sports-related concussion (SRC) is a public health problem in the United States, as evidenced by the public health approach of youth concussion laws which are now in effect in more than 40...
Novel Approaches for CEST Labeling, Detection, Quantification, and Translation
Principal Investigator:
Van Zijl, Peter
The overall Program Project focuses on the design and detection of bioorganic biodegradable Chemical Exchange Saturation Transfer (CEST) agents, with the ultimate goal of their practical application...
Annual Meeting of the NCRR/NIBIB Principal Investigators
Principal Investigator:
Van Zijl, Peter
We propose to continue the annual meetings of the Directors and Assistant Directors of the NCRR and NIBIB P41 Centers. The 2 1/2 day meeting is held annually in late June in Bethesda, Maryland. The...
Resource for Quantitative Functional MRI
Principal Investigator:
Van Zijl, Peter
The Resource for Quantitative Functional Magnetic Resonance Imaging is an interdepartmental and interdisciplinary laboratory combining facilities of the F.M. Kirby Research Center for Functional...
Biomarkers of Facioscapulohumeral Muscular Dystrophy (FSHD)
Principal Investigator:
Wagner, Kathryn R.
This NIH-funded study is established to identify biomarkers for facioscapulohumeral muscular dystrophy (FSHD). FSHD patients and their unaffected first degree relative will undergo open muscle biopsy...
Duchenne Muscular Dystrophy: Double-Blind Randomized Trial to Find The Optimum Steroid Regimen (FOR-DMD)
Principal Investigator:
Wagner, Kathryn R.
This Phase III multi-center, double-blind, parallel group, 36 - 60 month study funded by the NIH will compare three corticosteroid regimens in wide use in DMD: 1) daily prednisone (0.75 mg/kg/day...
Myostatin regulates fate of satellite cells in dystrophic muscle
Principal Investigator:
Wagner, Kathryn R.
The goal of this proposal is to determine whether myostatin, expressed in both skeletal muscle and fibroblasts, regulates the conversion of satellite cells to fibroblasts and whether this conversion...
A Three Dimensional Environment for Skeletal Muscle Stem Cell Transplantation
Principal Investigator:
Wagner, Kathryn R.
The purpose of this collaborative project is to develop and test and injectable scaffold embedded with muscle stem cells and a Pfizer drug to facilitate muscle regeneration. Cell based therapies...
Biomarkers for Therapy of FSHD
Principal Investigator:
Wagner, Kathryn R.
The goal of this Senator Paul D. Wellstone Muscular Dystrophy Cooperative Research Center is to define modifying genes of FSHD and to determine, through novel animal models of FSHD, whether these are...

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