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Human Cord Blood Stem Cell in a Mouse Model of Neonatal Stroke

Neonatal stroke occurs in 1 per 4000 live term births and causes cerebral palsy, developmental delays and seizures. Diagnosis of neonatal stroke is delayed and therefore the development of effective treatments has been difficult. New strategies are needed to improve recovery after neonatal stroke.

Our goals are to:

  1. to begin to determine the usefulness of human cord blood derived stem cells for the treatment of neonatal stroke
  2. to develop new hypotheses regarding cord blood stem cell biology and therapeutic targets for neonatal stroke 
  3. to determine how human cord blood stem cells impact the birth of new brain cells after neonatal stroke.  

Approaches:

Human cord blood stem cells will be injected into a mouse model of neonatal stroke. State-of-the-art techniques will be used to determine proteins that are increased or decreased in the injured neonatal mouse brain after stroke in response to the stem cells, and assess their impact upon new cell birth during recovery. 

Significance and Relevance:

This work will lay a firm foundation for multiple important future research studies to develop new therapeutic targets, generate novel hypotheses about how human cord blood stem cells function in the injured immature brain, and produce pre-clinical data that will guide future clinical studies in neonatal stroke. This work will also establish new biotech resources in the Maryland in the forms of new investigators to the field of stem cell translational research, new technicians trained, and new large publicly available datasets on protein expression from the injection of these human cord blood stem cells into a model of neonatal stroke.

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