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Funded Research Projects

Human Locomotor Plasticity in Health and Disease
Principal Investigator:
Bastian, Amy
Sponsored by the National Institutes of Health -- 5R01HD048741-06. Walking patterns can adapt on short timescales (minutes to hours) to temporary conditions, such as icy sidewalks. They can also...
Mechanisms and Rehabilitation of Cerebellar Ataxia
Principal Investigator:
Bastian, Amy
Sponsored by the National Institutes of Health -- 2R01HD040289. Cerebellar damage disrupts movement coordination. Actions ranging from walking to reaching become inaccurate and difficult to control...
Maternal Child Health Careers/Research Initiatives -- Undergraduate Program
Principal Investigator:
Belcher, Harolyn
Sponsored by DHHS/CDC -- 1U50MN000025. Healthy People 2020 highlights the importance of eliminating health disparities and increasing the quality and years of healthy life free of preventable disease...
Kennedy Krieger Center for Child and Family Traumatic Stress - Integrated Trauma Approaches
Principal Investigator:
Belcher, Harolyn
The goals of the Kennedy Krieger Centet for Child and Family Traumatic Stress Trauma Intervention Program (TIP) are to: Evaluate the feasibility and effectiveness of evidence-based treatment...
Relationship of MRI to ASIA Impairment Scale in Chronic Spinal Cord Injury
Principal Investigator:
Belegu, Visar
Structural & functional MRI studies of the central & peripheral nervous system in healthy children & children with spinal cord injury at 1.5 & 3.0 T Development of imaging...
Intellectual and Developmental Disabilities Research Centers 2008
Principal Investigator:
Cataldo, Michael
This application for continued support of Years 21 through 25 of the Mental Retardation and Developmental Disabilities Research Center (MRDDRC) at the Kennedy Krieger Institute and Johns Hopkins...
Developing a Means of Comparing Expenditures at Three Models of Nonpublic Special Education Services at a Private Special Education School in Baltimore, Maryland
Principal Investigator:
Church, Robin
Currently, there is no uniform means of determining the true cost of nonpublic special education in Maryland. Today, tuition is used as “the cost” of providing these programs. The proposed project...
Anticonvulsants, Ischemic Seizures and Regeneration in the Immature Brain
Principal Investigator:
Comi, Anne
Neonatal stroke affects one in 4000 term births and frequently results in cognitive impairments. Neonatal strokes present with seizures, and anticonvulsants (usually phenobarbital) are administered...
EEG-Based Assessment of Functional Connectivity in Autism
Principal Investigator:
Ewen, Joshua
Sponsored by the National Institutes of Health -- 1K23NS073626-01. There are substantial data to suggest that altered cerebral connectivity is a key aspect of the neurobiology of autism....
Comprehensive Long-Term Evaluation of the Gunn Rat Kernicterus Model
Principal Investigator:
Fatemi, S. Ali
The proposed project is the initial phase of a long-term endeavor to develop therapies that will help patients with dyskinetic cerebral palsy related to mitochondrial dysfunction and a Kernicterus-...
Study of White Matter Development in a Rodent Model of Perinatal Brain Injury
Principal Investigator:
Fatemi, S. Ali
This is a Mentored Clinical Scientist Research Career Development Award allowing Dr. Fatemi to develop a career as an independent investigator in the field of translational neuroscience research,...
Mentored Clinical Scientist Research Career Development Award
Principal Investigator:
Fatemi, S. Ali
The proposed training will prepare a young pediatric neurology faculty member for a career as an independent investigator in the field of translational neuroscience research, focusing on perinatal...
An adaptive, phase IIB/III, double-blind, randomized, placebo-controlled, multi-center study of the safety and efficacy of NaBen® (sodium benzoate), a d-amino acid oxidase inhibitor, as an add-on treatment for schizophrenia in adolescents
Principal Investigator:
Findling, Robert
Phase IIb Objectives: The primary objective of the Phase IIb portion of this study is to evaluate NaBen® (sodium benzoate) (1000 mg/day) safety and effectiveness and to determine the final sample...
Validation Study of the Aggression Diary
Principal Investigator:
Findling, Robert
The primary objective of this study is to conduct psychometric tests on the electronic observer- reported (eObsRO) Aggression Diary to evaluate whether the diary is a valid and reliable measure for...
Phase 2 of Growth Hormone for Treatment of Albright Hereditary Osteodystrophy
Principal Investigator:
Germain-Lee, Emily
Sponsored by the Food and Drug Administration -- 5R01FD003409-02. Albright hereditary osteodystrophy (AHO) is a rare genetic disorder caused by heterozygous inactivating mutations in the gene...
Osteogenesis Imperfecta Clinic
Principal Investigator:
Germain-Lee, Emily
Sponsored by the Harry Headley Charitable & Research Foundation. Funding for an independent clinician/researcher to work with Dr. Jay Shapiro in the OI Clinic.
Retrospective Chart Review of Growth in Osteogenesis Imperfecta
Principal Investigator:
Germain-Lee, Emily
The purpose of this research is to assess the growth parameters(height and weight) in osteogenesis imperfecta during infancy, childhood, and adolescence with the ultimate goal of determining whether...
Reward System in Autism
Principal Investigator:
Goldberg, Melissa
It is a core feature of autism that social interactions appear to be far less rewarding for autistic children compared to typically developing children. Based on this observation, one would predict...
An evaluation of differential reinforcement on appropriate toy skills
Principal Investigator:
Gonzalez, Melissa
The purpose of the current study will be to increase the play skills for six children with developmental disabilities, who display limited interest in toys in a free operant setting. It is...
Translational Analyses of Chronic Aberrant Behavior Across the Lifespan
Principal Investigator:
Hagopian, Louis
The goal of the proposed line of research is to gain a better understanding of the processes that evoke and maintain severe problem behavior (i.e., chronic aberrant behavior) in persons with...
Behavioral Economics in MR/DD and Behavior Disorders (2)
Principal Investigator:
Hagopian, Louis
Assessments of severe behavior disorders of children with intellectual and developmental disabilities (IDD) have revealed that behavior problems are often maintained by their functional outcomes (or...
Delineating subtypes of self-injurious behavior maintained by automatic reinforcement
Principal Investigator:
Hagopian, Louis
Self-injurious behavior (SIB) is one of the most serious problems experienced by individuals with intellectual disabilities. The standard of care for the assessment of SIB involves conducting a "...
Quantitative mapping of the basal ganglia and related structures in children with dyskinetic cerebral palsy
Principal Investigator:
Hoon, Alexander
Cerebral palsy (CP) refers to a group of motor-impairment syndromes secondary to genetic and acquired disorders of early brain development.  When the underlying disorder affects the basal...
Neurotrophin Protection of Hypoxic Ischemic Brain Injury
Principal Investigator:
Hossain, Mir Ahamed
Perinatal hypoxia-ischemia (HI) is a major cause of life-long neurological disability such as cerebral palsy. There are few treatments available for this devastating disorder. For the next period of...
Functional and Neurovascular Biomarkers for Huntington’s disease using MRI at 7T
Principal Investigator:
Hua, Jun
Oxidative stress and metabolic disturbances in the brain are believed to be involved in HD pathogenesis. Functional and neurovascular brain changes may represent altered neuronal physiology and...

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