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Clinical Research Projects

Movement-Based Mindfulness Training for Children with ADHD: A Feasibility Study
Principal Investigator:
Mostofsky, Stewart
Attention Deficit Hyperactivity Disorder (ADHD) has tremendous individual and societal impact. Current standard treatments can provide short-term reductions in symptom severity; however, there...
Neurology of Deficient Response Control in ADHD
Principal Investigator:
Mostofsky, Stewart
Building on evidence established in the initial grant period, the overall goals of the proposed study, “Neurology of Deficient Response Control in ADHD,” are to apply advanced neuroimaging and...
Motor Skill Learning in Autism
Principal Investigator:
Mostofsky, Stewart
Abnormalities on motor examination have often afforded valuable insights into developmental disorders of the brain; such abnormalities have been well documented in individuals with autism and, in...
Anomalus Motor Physiology in ADHD
Principal Investigator:
Mostofsky, Stewart
The hypothesis of this study is that the neuromotor anomalies present in children with ADHD will be associated with deficient intracortical and interhemispheric inhibition of the motor cortex. This...
Neurologic basis of inhibitory deficits in ADHD
Principal Investigator:
Mostofsky, Stewart
Prevailing hypotheses implicate deficient response inhibition as one of the fundamental features driving the pathophysiology of ADHD. Results from studies of lesions in animals and humans led many...
Tourette Syndrome: Functional Imaging of Motor Activation Pathways in Verbal and Motor Tics
Principal Investigator:
Mostofsky, Stewart
Tourette Syndrome (TS) is a disorder characterized by frequent motor and verbal tics. The exact mechanism of tic generation and the pathophysiology of TS is widely debated but believed to be related...
Motor skill learning in autism: assessment and treatment of altered patterns of learning
Principal Investigator:
Mostofsky, Stewart
Detailed study of motor impairments in autism can provide valuable insights into the neural basis of the disorder and help to guide its treatment. Given the developmental nature of autism, during the...
Creating a Pediatric Imaging-Genomics Data Resource
Principal Investigator:
Mostofsky, Stewart
Along with investigators at 8 other sites across the U.S., we will assemble a large, cross-sectional imaging-genomics dataset. The major aim of our proposal is to create a database that is...
Tactile Adaptation in Tourette Syndrome: Probing GABA-Mediated Neuroplasticity
Principal Investigator:
Mostofsky, Stewart
Tourette Syndrome (TS) is a common developmental neuropsychiatric disorder that can have a substantial impact on quality of life. Despite being first described over a century ago, the neurobiology of...
Quality Assurance of Sequential Finger Tapping Task Data Received from the University of Iowa
Principal Investigator:
Mostofsky, Stewart
This application is being submitted in order to assess with task development of Brain Structure and Function in Juvenile Huntington Disease at Roy J. & Lucille A. Carver College of Medicine....
Adolescent Changes in Brain and Behavior in Boys and Girls with ADHD
Principal Investigator:
Mostofsky, Stewart
Children with ADHD are at risk for a host of deleterious outcomes including impaired social relations, academic difficulties, criminality, and comorbid psychopathology (substance use, depression,...
Tourette Syndrome Neuroimaging Consortium Pilot
Principal Investigator:
Mostofsky, Stewart
Important research on Tourette Syndrome (TS) is proceeding along several fronts, from gene-hunting to controlled trials of new treatments. The Tourette Syndrome Association (TSA) has fostered...
KKI Weblink for researchers in Rett Syndrome
Principal Investigator:
Naidu, SakkuBai
Creation of a Weblink for Researchers in Rett syndrome to request de-identified data from clinical evaluations collected on our patients with Rett syndrome (RTT) in The Natural History study "...
Dextromethorphan in Rett syndrome
Principal Investigator:
Naidu, SakkuBai
Dr. SakkuBai Naidu of the Kennedy Krieger Institute is initiating a clinical drug trial using dextromethorphan (DM) in Rett Syndrome (RTT) at the Pediatric Clinical Research Unit (PCRU) of the Johns...
Placebo-Controlled Trial of Dextromethorphan in Rett Syndrome
Principal Investigator:
Naidu, SakkuBai
Dr. Sakkubai Naidu, Principal Investigator, is initiating a double blinded placebo controlledclinical drug trial using dextromethorphan (DM) in Rett Syndrome (RTT), at the PediatricClinical Research...
Human Induced Pluripotent Stem Cells (hiPSC) in Rett syndrome
Principal Investigator:
Naidu, SakkuBai
Skin biopsy will be obtained for fibroblast culture from patients with a known MECP2 mutation as well as skin fibroblasts already present in the KKI’s tissue repository from patients with known...
Perspectives: Cross Sectional Comparison of the Perceptions of Caregivers of Children with Disabilities Regarding Their Own Wellbeing and Availability of Support
Principal Investigator:
O'Connor Leppert, Mary
Our plan is to investigate emotional and physical wellbeing and preparedness for the future among three different cohorts of caregivers: Those with children with intellectual disability...
Database for Preschoolers with Developmental and Behavioral Concerns
Principal Investigator:
O'Connor Leppert, Mary
This study focuses on the development and operation of a clinical database for children (0-5 years of age) with Developmental and Behavioral Concerns attending the preschool interdisciplinary clinic...
The Medical Evaluation of Autism in Preschoolers: Examining the Discrepancies between Parental and Clinical Impressions
Principal Investigator:
O'Connor Leppert, Mary
The proposed study will examine a clinic population of children being evaluated for early developmental delays in order to investigate how often parents and clinicians differ in their opinions...
Functional Connectivity ToolKit
Principal Investigator:
Pekar, James
Functional connectivity (FC) is defined as synchrony between neural signals from different locations; collections of regions displaying consistent synchrony are referred to as networks. Spontaneous...
Analysis of Genetic Variation in Neurodevelopmental Disorders
Principal Investigator:
Pevsner, Jonathan
We propose to sequence genomic DNA from patients with neurodevelopmental disorders, including autism, to study the nature and extent of genetic variation. To do this, the PI’s laboratory will study...
Chromosomal abnormalities underlying developmental disabilities
Principal Investigator:
Pevsner, Jonathan
The research question we would like to address is whether children with developmental disabilities have identifiable chromosomal abnormalities. The approach is in four parts: (1) prescreen and...
Developmental Trajectories of Impairments, Associated Health Conditions, and Participation of Children with Cerebral Palsy
Principal Investigator:
Pidcock, Frank
The purpose of this research study is to fill the gaps in fundamental knowledge of Cerebral Palsy by determining how children with cerebral palsy or with gross motor delay change in their balance,...
Pediatric Constraint-Induced Movement Therapy for Children with Hemiparesis: Outcomes of a Clinical Model
Principal Investigator:
Pidcock, Frank
Does the function of children with hemiparesis improve after treatment involving constraint of the less impaired upper extremity in conjunction with intensive therapies? We will investigate this...
Using Xbox Kinect based sensory technology to improve the functional mobility by allowing remote monitoring and modification of therapeutic activities for children with Cerebral Palsy in the home
Principal Investigator:
Pidcock, Frank
This is a small fesibility study where Kennedy Krieger will partner with Richard Simpson a rehabilitation engineer to provide the therapeutic and technologic resources for developing and implementing...
Retrospective analysis of risk factors associated with auditory processing disorder: SCAN-3 vs. LiSN-S
Principal Investigator:
Pillion, Joseph
Due to their complexity and variability, disorders involving auditory processing lack a consistent definition and diagnostic criteria. These disorders are characterized by difficulty comprehending of...
Why parents choose or decline Complementary and Alternative Medicine services in the acute pediatric inpatient rehabilitation setting
Principal Investigator:
Prestwich, Suzanne
Complementary and Alternative Medicine (CAM) usage in the general population is becoming more common as is usage in children. Use in children with chronic illness such as oncology patients, ADHD and...
Role of Peripheral and Brain Iron in the Development of Attention and Cognitive Control
Principal Investigator:
Pritchard, Alison
Emerging research implicates iron deficiency in childhood externalizing disorders featuring deficits in attention and cognitive control, such as Attention-Deficit/Hyperactivity Disorder (ADHD) and...
Construct and Predictive Validity of the Capute Scales
Principal Investigator:
Pritchard, Alison
Primary care physicians (PCPs) are often presented with the responsibility of early identification of developmental delay and other types of disorders, due to their early and ongoing contact with...
Outpatient Research Registry
Principal Investigator:
Pritchard, Alison
The primary objective of this protocol is to gather information on Neuropsychology outpatients that can later be accessed for screening purposes (to determine eligibility for research studies...
Executive Function and Academic Achievement in Children with a History of Prematurity
Principal Investigator:
Pritchard, Alison
The proposed study will be a retrospective review of previously collected clincal neuropsychological testing data, which will be deidentified for the purpose of this research study. The first...
Effect of glycerol trierucate on clinical course of Adrenoleukodystrophy
Principal Investigator:
Raymond, Gerald
Adrenoleukodystrophy is a disorder of very long chain fatty acids secondary to defects in peroxisomal beta oxidation. The accumulation of these fatty acids results in a disorder of the adrenal glands...
Collaborative Assessment of Pediatric Transverse Myelitis; Understand, Reveal, Educate. CAPTURE Study
Principal Investigator:
Recio, Albert
Currently, there are no uniform outcome measures to assist in guiding therapies. This multi center study proposes a unique opportunity to examine the outcomes of acute treatment and potentially...
Virtual Sailing Simulator in Individuals with Spinal Cord Injury
Principal Investigator:
Recio, Albert
The benefits of sport and recreational activities for the disabled are well recognized from the standpoint of health and quality of life. Yet there remains a lack of options for most disabled people...
Assessing the Impact of Skin Tears on Goal-Directed Therapy Plans Among Individuals with Traumatic Spinal Cord Injury (SCI)
Principal Investigator:
Recio, Albert
To explore how skin tears affect therapy plans in order to promote an optimal wound healing environment and, describe how this modification may influence the achievement of therapy goals among...
Developmental Outcomes in Children with Unilateral and Mild/Moderate Hearing Loss
Principal Investigator:
Reeseman, Jennifer
The primary goal of the present study is to begin to develop a program of research to capture developmental outcomes in children with hearing loss, with a current focus on unilateral (UL) and mild/...
Validation of a Modified Signed Paired Associates Test for Deaf Children
Principal Investigator:
Reesman, Jennifer
There are no published measures available that assess language related memory for children who communicate using American Sign Language (ASL). Most memory measures are created using spoken language,...
Utility of the Immediate and Post-Concussion Assessment and Cognitive Testing (ImPACT) test with Deaf and Hard-of-Hearing Adolescents
Principal Investigator:
Reesman, Jennifer
The present research seeks to examine whether the ImPACT test provides an accessible means of assessment for adolescents who are deaf or hard-of-hearing, as this tool has not previously been...
Cognitive, Behavioral, and Educational Outcomes in At-Risk Children with Hearing Loss
Principal Investigator:
Reesman, Jennifer
Children with hearing loss are at increased risk for poor cognitive, behavioral and educational outcomes. The present study seeks to identify correlates of poor outcomes and identify predictors via a...
Facial Dysmorphology in Children with Intellectual and Developmental Disabilities
Principal Investigator:
Rooker, Griffin
Recent literature has demonstrated an association between autism spectrum disorders and characteristic dysmorphologies of the face and brain. The current study extends this line of investigation by...
Individualizing Learning Arrangements for Children with Intellectual Disabilities
Principal Investigator:
Rooker, Griffin
The frequent and immediate delivery of reinforcers (rewards) following completion of academic tasks and related activities is an integral part of many educational programs for children with...
Delay Discounting in Children with ADHD: Neuroimaging and Behavioral Correlates
Principal Investigator:
Rosch, Keri
My long-term career goal is to establish a research program to improve treatments for ADHD, with an emphasis on doing so through improved understanding of alterations in cognition and motivation in...
The Association Between Lean Body Mass and Functional Outcomes in Individuals with Spinal Cord Injury
Principal Investigator:
Sadowsky, Cristina
What is the correlation between lean body mass (LBM) and functional outcome in individuals with spinal cord injury (SCI)? We plan to determine the association between (LBM) and functional outcomes as...
The Efficacy of Aquatic Locomotor Training Compared to Overground Locomotor Training in Improving Ambulatory Function and Health-Related Quality of Life
Principal Investigator:
Sadowsky, Cristina
The aim of this study is to define and evaluate the efficacy of ALT compared to overground LT in improving ambulatory function and health-related quality of life. We hypothesize, that ALT is capable...
Pediatric Multicenter Evaluation of Notable SCI Outcome Instruments, evaluation of Outcome Instruments when Applied to Children
Principal Investigator:
Sadowsky, Cristina
The overall objective of this research project is to establish pediatric psychometric support (usability, reliability, validity) of outcomes instruments that have been recommended for use in spinal...
Linking Adult and Pediatric Outcomes Instruments
Principal Investigator:
Sadowsky, Cristina
To validate the estimates used to link the Shriners Hospitals for Children (SHC) pediatric spinal cord injury (SCI) general mobility, manual mobility, power mobility and daily routine computer...
SIMS -- Spinal Cord Injury Management System
Principal Investigator:
Sadowsky, Cristina
To define the treatment modality and co-factor variables which influence the response to Activity Based Restorative Therapies (ABRT) in individuals with Spinal Cord Injury (SCI). To...
Relation of Severity of injury with Testosterone profile & osteoporosis in spinal cord injured men
Principal Investigator:
Sadowsky, Cristina
Hypothesis: Higher spinal cord injury neurologic level correlates with decreased testosterone level and increased prevalence of secondary osteoporosis.  Spinal cord injury is more common in...
Incidence of Osteoporosis in Patients with Chronic Spinal Cord Dysfunction
Principal Investigator:
Sadowsky, Cristina
Research Question: Prevalence of osteoporosis in patients with traumatic and non-traumatic spinal cord injury. Secondary Question: Relationship between bone mass, injury level and grade (ASIA),...
Patterned FES Ergometry of Arm and Shoulder in Individuals with Spinal Cord Injury
Principal Investigator:
Sadowsky, Cristina
Recent evidence suggests that FES can improve certain functions in the Central Nervous System (CNS) following injury or disease; it can enhance motor recovery, change H reflex and flexor reflex...
Relation of HDL levels with home based Activity Based Restorative Therapies in spinal cord injured adults
Principal Investigator:
Sadowsky, Cristina
Hypothesis: HDL levels increase following home based Activity Based Restorative Therapies (ABRT) The effect of exercise on lipid profile is well documented in the able bodied population. The effect...
Comorbidities in Children and Adolescents with Seizures
Principal Investigator:
Salorio, Cynthia
This current study will examine symptoms of inattention, hyperactivity, anxiety, and mood problems in a large, clinical sample of children and adolescents with epilepsy. In addition to identifying...
Sedation Strategy and Cognitive Outcome After Critical Illness in Early Childhood: RESTORE-Cognition
Principal Investigator:
Salorio, Cynthia
The purpose of RESTORE-cognition is to determine the relationships between sedative exposure during pediatric critical illness and long-term neurocognitive outcomes. We will assess multiple domains...
ArmAware: a novel device to treat hemiplegia and hemispatial neglect
Principal Investigator:
Salorio, Cynthia
The Investigators have developed a novel therapeutic device called ArmAware, that is designed to be an adjunctive treatment for adults and children with hemiparesis (weakness on one side of the body...
Longitudinal Study of Brittle Bone Disease
Principal Investigator:
Shapiro, Jay
The objective of this protocol is to conduct a longitudinal multidisciplinary investigation of the natural history, current therapeutic interventions, morbidity, and mortality in people with OI...

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