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Clinical Research Projects

Student-Centered Behavioral Interventions to Reduce Challenging Behavior in the Classroom
Principal Investigator:
Kahng, SungWoo
Aggressive behavior in young children is a known risk factor for youth violence (CDC, 2011). New methods for preventing youth violence and juvenile delinquency are needed to address this growing...
First Trimester Diagnosis of Smith-Lemli-Opitz Syndrome
Principal Investigator:
Kratz, Lisa
Is sterol analysis of direct chorionic villus material or amniotic fluid an accurate method for first trimester diagnosis of Smith-Lemli-Opitz syndrome?
X-Linked Dominant Conradi-Hünermann Syndrome: Clinical and Biochemical Phenotype in Affected Males
Principal Investigator:
Kratz, Lisa
X-Linked Dominant Conradi-Hünermann Syndrome (CPDX2) is a rare disorder of cholesterol biosynthesis caused by a deficiency of 3beta-hydroxysteroid-8, 7-isomerase (sterol isomerase), an enzyme encoded...
Risk factors for persistent self injury
Principal Investigator:
Kurtz, Patricia
The purpose of this study is to assess 5 factors believed to be related to the persistence of self-injurious behavior (SIB): parenting practices, child communication, parent depression, parent stress...
Assessment and treatment of severe problem behavior in individuals with intellectual/developmental disabilities
Principal Investigator:
Kurtz, Patricia
The purpose of the current proposal is to develop a research database comprised of cases treated for severe problem behavior by the Neurobehavioral Inpatient and Outpatient Programs at KKI. The...
Sleep and Cognitive Function after Mild Traumatic Brain Injury in Adolescents
Principal Investigator:
Lam, Janet
After mild traumatic brain injury, many adolescents complain of sleep problems and encephalopathy. This study aims to measure both of these complaints in an objective way to quantify how they are...
Sleep disturbances in neurobehaviorally challenged children with sickle cell disease: A pilot study
Principal Investigator:
Lance, Eboni
This study aims to evaluate sleep in a sample of children, adolescents, and young adults with SCD referred for neurobehavioral evaluation for academic and cognitive difficulties. We will further test...
Effects of Self-Generated Experiences on Social Cognitive Development in Young Children with Autism
Principal Investigator:
Landa, Rebecca
Sponsored by Autism Speaks -- 7746. This study will test whether a novel treatment for social impairment in young children with autism spectrum disorders (ASD) leads to improvement at behavioral and...
Autism and the Development of Relational Awareness
Principal Investigator:
Landa, Rebecca
Aims of the proposed research are: to test hypotheses about a deficit in understanding the relationship between objects (e.g., stimulus and reward) in autism, and how this relates to rule...
Assessing the Efficacy of a Gaze-Contingent Computer Interaction Game, Targeting Social Communicative Use of Directional Gaze
Principal Investigator:
Landa, Rebecca
This study is being done to examine the impact of an interactive, socially-directed computer game on the use of eye gaze for initiating social interactions in children with autism spectrum disorders...
Optimizing Social and Communication Outcomes for Young Children with Autism
Principal Investigator:
Landa, Rebecca
The overarching goal of the proposed project is to rigorously test an intervention program for caregivers and their toddlers with autism that is developmentally informed, child-centered and focused...
Social Skills Intervention for School-aged Children with ASD
Principal Investigator:
Landa, Rebecca
Primary Objective: Our primary objective for this study is to test the effectiveness of two distinct models of social skills group interventions (SKILLS and ENGAGE) with an ethnically and...
Training Clinicians in Cognitive Behavior Therapy (CBT) for Children with Autism Spectrum Disorders (ASD)
Principal Investigator:
Landa, Rebecca
Children with high-functioning autism spectrum disorders (ASD) are at greater risk for developing mental health problems, particularly anxiety symptoms. Previous studies have demonstrated reductions...
Developmental and Augmented Intervention for Facilitating Expressive Language
Principal Investigator:
Landa, Rebecca
Children who do not communicate with spoken words or an augmentative/alternative communication system are an underserved group among those with autism spectrum disorders (ASD). Because caregivers are...
Parent-Mediated vs. Center Based Intervention for Toddlers with ASD: an RCT
Principal Investigator:
Landa, Rebecca
The major focus of the study is to evaluate the relative impact of two different intervention experiences on social and communication development of minority and underserved toddlers with ASD and...
Early Detection, Intervention, and Neurobiology in Autism: Neurobiology Portion
Principal Investigator:
Landa, Rebecca
This research is being done to learn more about the brain development in children with autism and related disorders. We will be looking at blood samples to examine substances that influence early...
School-Age Children with Autism with Limited Expressive Language Skills: An Intervention Study
Principal Investigator:
Landa, Rebecca
This project will address a major challenge to the field of autism research: improving expressive communication in children with autism who have reached school age but have not acquired functional...
A Comprehensive Approach to Intervention for Toddlers at Risk for ASD
Principal Investigator:
Landa, Rebecca
Research questions are: What are early intervention effects on developmental trajectory and autism symptoms in 14- to 22-month-olds with social and communication delays that indicate high...
Early Detection, Intervention and Neurobiology in Autism: Early Intervention Portion
Principal Investigator:
Landa, Rebecca
The overall goal of the study is to counter the effects of increased N-methyl-D-aspartate (NMDA)/glutamate receptors in mutation-positive Rett syndrome (RTT) subjects by use of dextromethorphan (DM...
NCS Formative Research Project #8 – Development and Validation of Autism Case Confirmation Approaches for Use in the National Children’s Study
Principal Investigator:
Landa, Rebecca
The overarching goal of this proposed project is to assess the criterion validity of three new autism spectrum disorder (ASD) case confirmation instruments against gold standard classification based...
Classroom-Based Early Intervention for Toddlers With Autism
Principal Investigator:
Landa, Rebecca
The proposed project seeks to continue research into the impact of early intervention targeting interpersonal synchrony on the process of social and communication development in toddlers with non-...
Care Navigation for Families of Individuals with Autism Spectrum Disorder
Principal Investigator:
Landa, Rebecca
The proposed study aims to study the effects of a Clinical Services Navigation (CSN) system to improve patient care and family satisfaction for children with a confirmed autism spectrum disorder (ASD...
Analyzing Movement of Infants at Risk for Autis
Principal Investigator:
Landa, Rebecca
Research question: 1) Will infants at high-risk for ASD display significantly different motions than infants identified as low-risk for ASD? 2) Can the effect of ASD on motor development be used...
Development of a Social and Communication Intervention for Preschoolers with Autism
Principal Investigator:
Landa, Rebecca
This is a multiphase study designed to examine the proposed intervention and how it translates for use in authentic educational settings by teachers of preschoolers with ASD. The primary aim of this...
Autism Treatment Network: Program for the Comprehensive Care and Treatment of Autism
Principal Investigator:
Landa, Rebecca
The purpose of this study is to improve medical treatment of children and adolescents with autism by establishing standards of clinical care based on clinical practice and evidence from clinical...
Relationship Status Among Parents of Children with Autism Spectrum Disorders
Principal Investigator:
Landa, Rebecca
For this study, we will examine the relationship status of parents of children with autism spectrum disorders (ASD). We would like to understand the relationship status of biological parents of...
Validation of a Video-Guided Screening Instrument for Autism Spectrum Disorders
Principal Investigator:
Landa, Rebecca
The overarching goal of this proposed project is to assess the criterion validity of a new autism spectrum disorder (ASD) screening tool by comparing it to a gold standard ASD diagnostic tool known...
Personality Style and Parenting for Fathers of Children with Autism
Principal Investigator:
Landa, Rebecca
Goal: To create a better understanding of the experience of fathers of children with autism spectrum disorders (ASD). Specific Aims: To identify the extent which particular personality...
Multisite RCT of Early Intervention for Spoken Communication in Autism
Principal Investigator:
Landa, Rebecca
While significant progress has been made toward identifying effective interventions for preschool-age children with autism (National Research Council, 2001), few scientifically rigorous studies have...
Autism: Social and Communication Predictors in Siblings
Principal Investigator:
Landa, Rebecca
This is a longitudinal study of Autism Spectrum Disorders (ASD). Six groups will be assessed longitudinally. Group 1: siblings of probands with autism; (Group 2) late talkers having no family...
Regulation of Glioblastoma Stem Cells by Kruppel-like Factors
Principal Investigator:
Laterra, John
This research will examine mechanisms by which the family of Kruppel-like factors regulate the behavior, differentiation and tumor initiating ability of human GBM-derived stem cells. We will obtain...
Magnetic Resonance Imaging and Spectroscopy Biomarkers for Facioscapulohumeral Muscular Dystrophy
Principal Investigator:
Leung, Doris
This study, supported by the FSH Society, will utilize magnetic resonance imaging (MRI) and magnetic resonance spectroscopy (MRS) to develop non-invasive, quantitative imaging biomarkers for...
A Dose-Range Finding of Multiple Ascending Doses of ISIS 598769 Administered Subcutaneously to Adult Patients with Myotonic Dystrophy Type 1
Principal Investigator:
Leung, Doris
A Phase 1/2a Blinded, Placebo-Controlled Study to Assess the Safety, Tolerability, and Dose-Range Finding of Multiple Ascending Doses of ISIS 598769 Administered Subcutaneously to Adult Patients...
Bowel and Bladder Continence among Children with Spina Bifida: A Prospective Study
Principal Investigator:
Levey, Eric
The lack of effective bladder and/or bowel control is a significant barrier to the normal social and emotional development of children and adolescents with Spina Bifida. The study proposed in this...
Research Participation Survey
Principal Investigator:
Lipkin, Paul
The Research Participation Survey was designed as an informal operational survey to help the Department of Medical Informatics/IAN Research Project understand what motivates people to participate in...
Pilot Project to Assess Web-Based Family Recruitment for Autism Genetics Studies
Principal Investigator:
Lipkin, Paul
The overall goal of this project is to demonstrate that large-scale DNA collection is feasible and cost-effective. Aim 1: Demonstrate the accuracy of a rapid phenotyping paradigm in which...
Interactive Autism Network Research Database
Principal Investigator:
Lipkin, Paul
IAN will develop and maintain a national online research database for individuals affected by autism spectrum disorders (ASD) and their family members. This will allow targeted recruitment of...
Continued Impairment in Adolescents Who Have Outgrown ADHD
Principal Investigator:
Lipkin, Paul
Do adolescents who report that they have "outgrown" childhood Attention-Deficit/ Hyperactivity Disorder (ADHD) (diagnosed before age 10 years of age) continue to have symptoms of ADHD and impairment...
Outcome of Inclusion in Children with Pragmatic Language Impairment
Principal Investigator:
Lipkin, Paul
To determine if there is a relationship between the level of academic support and reading comprehension level by evaluating the difference in reading comprehension level in third grade in children...
Developmental Surveillance and Screening Policy Implementation Project
Principal Investigator:
Lipkin, Paul
The Developmental Surveillance and Screening Policy Implementation Project will select 15 pilot primary care pediatric practices to implement the AAP policy statement (anticipated publication of...
Oppositional Disorder, Toilet Training, and Paternal Status
Principal Investigator:
Logue, Dora
Examine the association between age of toilet training, father present in household and later development of oppositional disorder in childhood.
Identification of Barriers and Potential Solutions for Improving Compliance with Mental Health Care Treatment in Children and Adolescents: A Pilot Project
Principal Investigator:
Lopez-Arvizu, Maria Del Carmen
The Department of Psychiatry Clinic at Kennedy Krieger Institute has identified compliance as a major hindrance to mental health care, limiting mental health treatment outcomes and patient...
Neurobehavioral Late-Effects in Pediatric Brain Tumors
Principal Investigator:
Mahone, E. Mark
Radiation Therapy (RT) has been largely responsible for improving the survival rates of children with certain types of brain tumors, although this has come at a cost in terms of the neurodevelopment...
Frontostriatal Glutamate in ADHD: Neuropsychological and Behavioral Correlates
Principal Investigator:
Mahone, E. Mark
Sponsored by the National Institutes of Health -- R21MH092693-01. The overall goal of the proposed investigation, "Frontostriatal Glutamate in ADHD: Neuropsychological and Behavioral Correlates" is...
Prevalence of Reading Difficulties: 4th-8th Grade
Principal Investigator:
Mahone, E. Mark
The central goal of this project is to estimate the prevalence of various types of reading disability (RD) in the population of upper elementary and middle school students (grades 4 and 8). All data...
Reading Disability in Grades 3 - 8: Neurocognitive Factors and Behavioral Assessment
Principal Investigator:
Mahone, E. Mark
This project has two purposes: to examine the validity of a response-to-intervention (RTI) approach to identifying children with reading disabilities (RD) who are beyond the initial stages of...
Assessment of Neurocognitive Factors in Reading: Grades 4-8
Principal Investigator:
Mahone, E. Mark
The focus of the current research is to examine the extent to and manner in which difficulties in component reading skills (both top down and bottom up), such as decoding accuracy, fluency, and...
Reading Comprehension: Sources of Difficulty and Neurocognitive Correlates
Principal Investigator:
Mahone, E. Mark
It is well established that successful reading comprehension requires skilled word reading and strong language proficiency, and that word reading deficits are mainly responsible for reading...
GRAD Study (Genes, Reading and Dyslexia):Development of a Dyslexia Screening Test
Principal Investigator:
Mahone, E. Mark
This study will examine the relationship between reading associated cognitive competencies and genetic polymorphisms of primarily minority children (those with African or Hispanic heritage) with and...
ADHD in Preschool Girls: Longitudinal Analysis of Neuroimaging and Behavior
Principal Investigator:
Mahone, E. Mark
The overall goal of this project is to characterize the anomalous early development (brain, cognition, and behavior) of girls who present with the behavioral features of Attention Deficit...
Neuroimaging of Motor Stereotypies in Children with Autism
Principal Investigator:
Mahone, E. Mark
Complex motor stereotypies (i.e., apparently purposeless, rhythmical, repetitive movements) represent one of the core criteria—together with restricted interests, preoccupations, and rigidity—for...
The Effects of ADHD (Beyond Decoding Accuracy) on Reading Fluency and Comprehension
Principal Investigator:
Mahone, E. Mark
The central goal of this project is to understand how ADHD influences processing speed (as it relates to reading speed/fluency), working memory, and reading comprehension. Specifically, we will...
Genetic Influences on Sluggish Cognitive Tempo and Reading
Principal Investigator:
Mahone, E. Mark
The overall goal of this pilot study is to examine the relationships between neuropsychological skills and genetic polymorphisms of children ages 8-15 years who display slowed processing speed in the...
ADHD in girls: neuroimaging and executive behavior
Principal Investigator:
Mahone, E. Mark
This study is closed to participant accural and we are currently writing papers. This is a proposal to determine whether ADHD is associated with different brain anomalies/abnormalities in girls and...
CAARE (Creating Advances in Autism through Research Engagement) Project
Principal Investigator:
Menon, Deepa
The CAARE Project will develop and maintain an institutional research database for individuals affected by autism spectrum disorders (ASD) and their family members. This will allow targeted...

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