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Retrospective Analysis of Distal Femur and Femur Neck DXA Measurements in Adult Controls and in Patients with Spinal Cord Injury, Cerebral Palsy and Osteogenesis Imperfecta

Principal Investigator:
Jay
Shapiro

Loss of bone mineral density has been a consistent finding in non-weight bearing spinal cord injury (SCI) and cerebral palsy (CP) patients. DXA BMD of the total hip and femur neck and QCT-derived measures of femur bone strength are used to assess fracture risk. Osteogenesis imperfecta is another disorder characterized by increased fracture rate. In SCI and CP patients 80 % of fractures occur at the distal femur, frequently with minimal trauma.

Henderson and Hartke (1998) suggest that DXA bone density measurements at the distal femur may be more reliable indicators of the extent of bone demineralization and fracture risk than total hip or femur neck BMD. BMD relationships at the distal femur have not been obtained in adults. We hypothesize that the distal femur is; a) more sensitive than femur neck in reflecting BMD status, and b) more reflective of bone loss with age, non-weight bearing status or in certain genetic disorders (OI) than is the femur neck. 

This is a retrospective chart review involving no more than minimal risk. No patient visit is required. 

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