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Neuropsychological Functioning in Demyelinating Diseases
Demyelinating diseases are rare neurological autoimmune conditions characterized by inflammatory processes in which the myelin sheath surrounding axons within the central nervous system (CNS) is damaged. In the pediatric population, these conditions may be monophasic or chronic.
Typical monophasic disorders include ADEM and CIS, which include optic neuritis (ON) and transverse myelitis (TM), with some cases of ADEM or CIS progressing to become MS and NMO, which are chronic disorders.
Children are diagnosed earlier than adults, thus they are more likely to reach a more severe level of disability at a younger age. The compromised integrity and inflammation of myelin in these conditions causes significant impairments in functioning although the extent to which impairments are related to cognitive functioning in pediatric demyelinating disorders is unknown.The proposed study will examine combined results of measures administered as part of a clinical neuropsychological evaluation completed at either the Kennedy Krieger Institute or the University of Texas Southwestern Medical Center (UTSW) at Dallas.
This study is a retrospective review of previously collected clinical data at these two sites which will be deidentified for the purposes of this research. Data will be deidentified at the respective site prior to combining data.
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