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Functional Connectivity ToolKit

Principal Investigator:

Functional connectivity (FC) is defined as synchrony between neural signals from different locations; collections of regions displaying consistent synchrony are referred to as networks. Spontaneous fluctuations throughout distributed intrinsic networks (INs) modulate BOLD fMRI data acquired from participants at “rest” (lying in a scanner). The opportunity to study brain function at “rest” reduces demands on participant compliance, allowing studies in populations who would have difficulties with conventional fMRI tasks. A growing literature reports on changes in resting FC with brain state, development, aging, disorders, and therapy. However, using FC in a quantitative manner to yield potential disease biomarkers will require fundamental improvements in data acquisition and analysis, which relate to concerns about the interpretation of fc-MRI results due to nuisances, modulators, and lags.

Nuisances of physiological origin, including respiration and cardiac pulsations, can yield synchronous signals that could be mistaken for FC; modulators of BOLD signals are physiological parameters linking neuronal activity with deoxyhemoglobin concentration; lags are the (spatially non-uniform) delays between neuronal activity and hemodynamic responses. The goal of this study is to develop advanced approaches to the acquisition and analysis of FC data.

Bradley L. Schlaggar, M.D., Ph.D., Named President and CEO of Kennedy Krieger Institute

We’re thrilled to welcome Bradley L. Schlaggar, M.D., Ph.D., to the Kennedy Krieger family as our next President and CEO.
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