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Exercise study of function and pathology for women with X-ALD
This study will comprehensively evaluate the corticospinal tract and the dorsal column-medial lemniscal tracts across the brain and cervical spinal cord with the purpose of understanding mechanisms of disability in women with adrenomyeloneuropathy (AMN). We hypothesize that: 1) tract-specific magnetization transfer imaging (MTI) and diffusion tensor imaging (DTI) will predict specific sensory and motor impairments (i.e., sensory loss and weakness) and disability; and 2) tract-specific MTI and DTI will predict who is likely to respond best to progressive resistive training. To test these hypotheses we are using advanced neuroimaging in combination with tools in the Motion Analysis Laboratory to understand the pathophysiology of lower extremity function, providing a more complete picture of how lower extremity function may improve following a progressive exercise paradigm.
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