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IDDRC Supported Projects

2018 IDDRC Projects and Supporting Cores

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Principal
Investigator
Grant Number and Title Translational Genetics Neuroscience Neuroimaging Behavior
Aggarwal R21NS096249-01A1: Oscillating Gradient Diffusion MRI and Quantitative Susceptibility Mapping in the Epileptogenic Brain       X  
Atkinson UL1-TR001079 (NBRU): Chronic Kidney Disease in Chldren Study (CkiD)         X
Bastian R01 HD040289: Mechanisms and Rehabilitation of Cerebellar Ataxia         X
Baumgartner R01 HL091541: Excitotoxicity in circulatory arrest-brain injury     X    
Bembea K23 NS076674: Novel methods of Brain Injury Detection and Outcome Prediction in Pediatric ECMO         X
Bjornsson DP5 OD017877: Clinical Confirmation of Novel Computational Genetic Elements   X      
Bjornsson DP5 OD017877: Exploring Kabuki Syndrome as a treatable cause of intellectual disaiblity   X      
Blue/Kannan R21 NS100085: Dendrimer Therapies for Treatment of Rett Syndrome     X X  
Brasic JHUSM BriteStar Award: The Feasibility Study of Metabotropic Glutamate Receptor Type 5 Function in Fragile X Syndrome         X
Budimirovic Ovid Therapeutics, Inc.: A Phase 2a, Randomized, Double-Blind, Parallel-Group, Proof-of-Concept Study Evaluating the Safety, Tolerability, and Efficacy of OV101 in Fragile X Syndrome         X
Burd K08 HD073315: IL-1β Regulation of Perinatal Brain Injury     X X  
Capone UL1-TR001079 (NBRU): Depression and Sleep Disorders in Adolescents and Young Adults with Down syndrome         X
Carnell UL1-TR001079 (NBRU): Neurobehavioral Influences on Body Weight         X
Cayton Vaught Edward E. Wallach Research Fellowship Grant and UM1 HG006542: Demystifying Unexplained Recurrent Pregnancy Loss Through Next Generation Sequencing Technologies   X      
Celnik R01 HD053793: Novel Strategies to enhance motor function after stroke         X

Celnik

R01 HD073147: Understanding motor behavior after stroke          X

Cheng

K01 AA020873: Neuroimaging of Eyeblink Conditioning in Subjects with Alcohol Use Disorders       X  
Comi Faneca 66 Foundation: Cannabidiol expanded access study in medically refractory Sturge-Weber syndrome X        
Comi Faneca 66 Foundation: Trial of sirolimus for cognitive impairments in Sturge-Weber syndrome X        

Cutting

R01 DK044003: Molecular genetics of cystic fibrosis: Creation and characterization of an airway epithelial cell line for stable expression of exogenous genes    X      
Edden Brian’s Hope Foundation: Nanodendrimer-Based Targeted Delivery of the N-Acetylcysteine for Adrenoleukodystrophy: A Pilot Study to Determine Feasibility of Clinical Translation       X  

Edden

UL1-TR001079 (NBRU): Dysfunction of Sensory Inhibition in Autism       X  
Ehsani Hopkins Science of Learning Institute: Neurophysiological Measures of Hazard Perception Among Novice and Teenage Drivers       X  
Everett R01 HD68446: GFAP Biomarker of Whole Body Cooling Outcome and Efficacy in the Neonate with HIE X     X  
Ewen R21 NS091569: Direct Examination of Imitation Based Learning in ASD X     X X
Fatemi R01 NS097511: Targeted Therapies for Neonatal White Matter Injury     X X  
Fatemi Brian’s Hope Foundation: Nanodendrimer-Based Targeted Delivery of the N-Acetylcysteine for Adrenoleukodystrophy: A Pilot Study to Determine Feasibility of Clinical Translation     X    
Fatemi A Cure for Ellie Foundation: Characterization of the Natural History of Leukoencephalopathy with Brainstem and Spinal Cord Involvement and Lactate Elevation X        
Findling R01 MH073967: Longitudinal Assessment of Manic Symptoms  X     X  
Findling NCT02674633: Software Treatment for Actively Reducing Severity of ADHD (STARS-ADHD) X        
Findling Supernus Pharmaceuticals, SPN810P301: A Randomized, Double-Blind, Placebo-Controlled Study to Evaluate the Efficacy and Safety of Molindone Hydrochloride Extended-Release Tablets for the Treatment of Impulsive Aggression in Pediatric Patients with Attention Deficit/Hyperactivity Disorder (ADHD) in Conjunction with Standard ADHD Treatment Objectives X       X
Findling Dasotraline Pediatric Extension Study X        
Findling Safety and Tolerability Study of SPD489 in Preschool Children Aged 4-5 Years, Diagnosed With Attention-deficit/Hyperactivity Disorder X        
Germain-Lee R21 HD078864: The Role of G Protein-Coupled Signaling in Neurocognitive and Psychosocial Abnormalities         X
Hagopian R01 HD076653: Delineating subtypes of self-injurious behavior maintained by automatic reinforcement         X
Hardwick R01 NS083373: Mechanisms of Neurodegeneration      X    
Harris Rubenstein Taybi Syndrome Foundation: Characterizing the Neurocognitive and Neurophysiologic Phenotype of Rubinstein-Taybi Syndrome X X     X
Hoover-Fong/Gunay-Aygun 03-HG-0264, NCT00068224: Clinical and Molecular Investigations into Ciliopathies   X      
Jacobson PCORI Research Institute: Surviving Cancer, Thriving in Life: Health-related Quality of Life after Pediatric Cancer         X
Jacobson PCORI Research Institute: Surviving Cancer, Thriving in Life: Health-related Quality of Life after Pediatric Cancer         X
Johnson U01 NS038455: Maternal Outcomes and Neurodevelopmental Effects of Antiepileptic Drugs (MONEAD)         X
Johnston 2K12 NS001696: Neurology Sciences Academic Development Award (NSADA) X X      
Johnston Kennedy Krieger Institute-Johns Hopkins Medicine Interdisciplinary Cerebral Palsy (CP) Center of Research Excellence (KKI-JHM CPCRE): Nanomedicine-Based Therapy for Perinatal White Matter Injury X   X   X
Kadam R01 HD090884: Mechanisms Regulating KCC2 Hypofunction During Refractory Seizures in a Mouse Model of Ischemic Neonatal Seizures     X    
Kamiya/Pletnikov R01 DA041208: Molecular Mechanism of Astrocytic Vulnerability to Adolescent Cannabis Use        X      
Kannan R01 HD069562: Mechanisms and Novel Therapy in Intrauterine Inflammation Induced Brain Injury       X  
Kannan R01 NS093416: Targeting Glutamate Carboxypeptidase in Perinatal Brain Injury     X X  
Keefer Private Donor: A Pilot Investigation of a Novel Child/Parent Mindfulness Intervention to Improve Emotional Dysregulation in Children with Autism Spectrum Disorders         X
Krinsky-McHale/Silverman P01 HD035897: Aging and Dementia in Adults with Down syndrome.  Subproject 2: (8402) Validation of Criteria for Identifying “MCI” in Adults with Down syndrome.  X       X
Lance 1K23HL133455: Neuroimaging, Protein Biomarkers, and Neurodevelopment in Very Young Children with Sickle Cell Disease X     X X
Landa R01 MH059630: Autism social and communication predictors in siblings X        
Laterra R01 NS076759: Suppression of Glioblastoma Stem Cells by Kruppel-Like Factor 9     X    
Laterra R01 NS096754: Chromatin Modifications in GBM-Propagating Cells     X X  
Lee R01 NS093213: Cell extrinsic factors’ roles on direct conversion to human induced neural crest   X      
Li R35 GM118172: Cellular Dynamics in Division, Motility, and Evolutionary Adaptation     X    
Lin UL1-TR001079 (NBRU): Noninvasive imaging and functional correlation of intracranial pial angiomatosis (SWS)       X  
Maegawa R01 NS079655: Development of an HTS assay for a neurological lysosomal disease    X      
Mahone R01 HD068425: Development of ADHD in Preschool Children: Neuroimaging and Behavioral Correlates        X X
Mahone UL1-TR001079 (NBRU): DNA Methylation in Children with ADHD and/or Dyslexia         X
Mahone Maryland State Department of Education (MSDE): Improving Equity in Access and Opportunity for Students with Disabilities         X
Mahone Maryland State Department of Education (MSDE):  School-Based Uses of Applied Behavior Analysis: Open Online Modules for Teachers, Administrators, and Special Education Student Support Staff         X
Mahone Department of Education (DOE): Neuroscience of Learning and the Learner         X
Meador U01 NS038455: Maternal Outcomes and Neurodevelopmental Effects of Antiepileptic Drugs (MONEAD)         X
Miller R01 EB020062:  Neurogenerative and Neurodevelopmental Subcortical Shape Diffeomorphometry       X X
Moler U01 HL094345: Therapeutic Hypothermia After Pediatric Cardiac Arrest: A Randomized Controlled Trial (THAPCA)       X X
Mostofsky R01 MH078160: 1/2 Anamalous Motor Physiology in ADHD       X X
Mostofsky R01 MH085328: Adolescent Changes in Brain and Behavior in Boys and Girls with ADHD of deficient response control in ADHD       X X
Mostofsky/Gilbert R01 NS096207: GABAergic Sensorimotor Dysfunction in Tourette Syndrome       X X
Naidu R01 FD004247: PH2 Study of dextromethorpan in the treatment of Rett syndrome X X X   X
Nebel K01MH109766: Visual-Motor Development in Infants at High Risk for Autism       X  
Northington R01 HD070996: Mechanisms of hypothermic neuroprotection in neonates     X X  
Pelled R01 NS072171: The role of transcallosal pathway to neuroplasticity following nerve injury     X    
Pevsner U01 MH106884: Role of somatic mosaicism in autism, schizophrenia and bipolar disorder brain   X      
Pevsner UL1-TR001079 (NBRU): DNA in Children with Developmental Disabilities   X      
Pletnikov R01 MH083728: DISC1 in Neuron-Astrocyte Interactions in Neurodevelopment    X      
Pritchard R03 EB023359: Role of Peripheral and Brain Iron in the Development of Attention and Cognitive Control       X X
Puts K99 MH107719: A Multimodal Investigation of Inhibitory Dysfunction in Autism Spectrum Disorder       X  
Reeves R01 HD038384: Genomic Approaches to Aneuploidy     X    
Reti R21 HD092915: Neuromodulation Treatment for Self-Injurious Behavior Associated with Intellectual and Developmental Disabilities     X    
Robertson 5U01NS081041-02: Approaches and Decisions in Acute Pediatric TBI (ADAPT)         X
Rosch K23 MH101322: Delay Discounting in Children with ADHD: Neuroimaging and Behavioral Correlates       X X
Ruble/Jacobson Saint Baldrick’s Foundation: Sleep and Neurocognitive Outcomes in Childhood ALL Survivors         X
Sadowsky Ekso Bionics, 105333: Adherence to Home-Based Functional Electrical Stimulation (FES) Exercise in Patients with Spinal Cord Injury (SCI) X       X
Salpekar NCT03371836: Use of Clobazam in Treating Anxiety Comorbid with Pediatric Epilepsy X       X
Scafidi K08 NS069815: Metabolic dysfunction and neuroprotection after pediatric head injury      X    
Schupf/Lott/Silverman U01 AG051412: Biomarkers of Alzheimer’s disease in adults with Down syndrome X X   X X
Schupf/Silverman P01 HD035897: Aging and Dementia in Adults with Down syndrome. Subproject 4: (8404) Genetic Epidemiology of Alzheimer’s Disease in Down syndrome X        
Seymour K23 MH107734:  Neurobehavioral correlates of frustration in ADHD       X X
Silverman P01 HD035897: Aging and Dementia in Adults with Down syndrome         X
Singer Tourette Association of America (TAA): Home-based Behavioral Intervention for Tics, Comparison of Home-based DVD Therapy and Psychologist-directed CBIT Treatment         X
Song Tourette Association of America (TAA): Home-based Behavioral Intervention for Tics, Comparison of Home-based DVD Therapy and Psychologist-directed CBIT Treatment     X    
Suskauer UL1-TR001079 (NBRU): Neural Basis of Impairments in Response Inhibition and Processing Speed         X
Suskauer R01 HD090266: Subtle Motor Functioning and Functional Connectivity in Youth Medically Cleared After Mild TBI       X X
Tifft NHGRI Rare Impact Award: Diagnosis and Segregation of Undiagnosed Disease     X    
Tycko/Silverman P01HD035897: Aging and dementia in adults with Down syndrome. Subproject 3: (8403) Epigenetic Modifiers in Down syndrome X        
Valle UM1 HG006542: Baylor-Johns Hopkins Center for Mendelian Genetics X X      
Vernon K08HD073492: Metabolic studies in disorders of branch chain amino acid metabolism   X X    
Wagner U54 HD060848: Biomarkers for Therapy of FSHD     X    
Wagner NCT01847573: Safety, Tolerability, and Pharmacokinetics of Single and Multiple Doses of HT-100 in Duchenne Muscular Dystrophy X        
Wang R21NS085358: DHHC 15 palmitoylation modulates striatal dopamine system    X      
Watkins R21NS091988: Drug Discovery for X-Linked Adrenoleukodystrophy    X X    
Watson 5R01 HD074757: Sedation Strategy and Cognitive Outcome After Critical Illness in Early Childhood         X
Wilson U54HD079123: IDDRC Research Component (6271): Multi-modal Treatment for Neonatal HIE: Hypothermia and Dendrimer Nanotherapy     X X X
Wu R21NS098018: In-Utero Characterization of Embryonic Mouse Brain Development and Injury with MRI       X  
Xia 5R01NS091165: Effect of IDH1 Mutation on Chromosome Instability   X X    
Yau R01EY014596: Melanopsin Photoreception and Signaling     X    
Zhang R01HD074593: Imaging neonatal hypoxic ischemic injury       X