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IDDRC Administrative Core Training and Education

Our Institutions hold training of future generations of scientists among its highest priorities. The IDDRC has contributed to addressing that priority since its establishment and throughout its two-decade plus history. Currently, there is increasing emphasis on training relevant to translational research focused on developmental disorders, consistent with broader NIH priorities, but training programs continue to subsume the full scope of content relevant to our field. Annually, Kennedy Krieger Institute graduates over 330 interns and fellows from its various training programs.

Our affiliation with The Johns Hopkins Institute for Clinical and Translational Research (ICTR) is a particularly valuable training asset. It supports formally established components of the University’s fellows training program, but it also provides resources for pilot and preliminary translational studies, along with Core resources complementary to our IDDRC. Support for fellows and junior faculty is clearly among the ICTR priorities. The ICTR’s focus is far broader than developmental disorders, but it includes a Neurobehavioral Research Unit with a strong emphasis on developmental disorders.

Another major component of the training mission is the coordination of many sponsored lectures and symposia occurring regularly throughout Kennedy Krieger Institute, the School of Medicine, the School of Public Health, and other schools within the University. For example, annually at the Kennedy Krieger Institute, over 90 lectures on intellectual disabilities are featured each year.

IDDRC Projects and Supporting Cores

Principal Investigator Grant Number and Title
Clinical Translational Core  
Boger R01AI093701, Novel Artemisinin derivatives for cytomegalovirus therapy
DeLeon/Cataldo P01HD055456 Translational analyses of chronic aberrant behavior across the life span
DeLeon R01HD049753 Behavioral economics in MRDD and behavior disorders
Everett R01HD68446, GFAP biomarker of whole body cooling outcome and efficacy in the neonate with HIE

Findling

R01MJ073967, Longitudinal assessment of manic symptoms 
Gipson 2K12NS001696, Rapalogues for Autism Phenotype in TSC (RAPT)

Krinsky-McHale/Silverman

P01HD035897, Aging and dementia in adults with Down syndrome:  Subproject 2

Landa

R01MH059630, Autism social and communication predictors in siblings
Landa R40MC26193 MCH research
Naidu R01FD004247, PH2 Study of Dextromethorpan in the treatment of Rett Syndrome
Schupf/Silverman P01HD035897, Aging and dementia in adults with Down syndrome; Subproject 4
Silverman P01HD035897, Aging and dementia in adults with Down syndrome
Schupf/Silverman/Lott U01AG051412, Biomarkers of Alzheimer’s disease in adults with Down syndrome
Tycko/Silverman P01HD035897, Aging and dementia in adults with Down syndrome; Subproject 3
Valle U54HG006542, Baylor-Johns Hopkins Center for Mendelian Genetics
Genetics Core  
Bjornsson, Hans DP50D017877, Exploring Kabuki Syndrome as a treatable cause of intellectual disaiblity
Crawford/Butchbach/Shaffer P20GM103464, Center for Pediatric Research: Identification of PSP neuroprotective compounds as SMN2 inducers 
Gipson 2K12NS001696, Rapalogues for Autism Phenotype in TSC (RAPT)
Lee R01NS093213, Cell extrinsic factors’ roles on direct conversion to human induced neural crest
Maegawa R01NS079655, Development of an HTS assay for a neurological lysosomal disease 
Pevsner U01MH106884, Role of somatic mosaicism in autism, schizophrenia and bipolar disorder brain
Valle U54HG006542, Baylor-Johns Hopkins Center for Mendelian Genetics
Vernon K08HD073492, Metabolic studies in disorders of branch chain amino acid metabolism
Wang, Tao R21NS085358, DHHC 15 palmitoylation modulates striatal dopamine system 
Watkins R21NS091988, Drug discovery for X-linked adrenoleukodystrophy 
Translational Neuroscience Core  
Baumgartner R01HL091541, Excitotoxicity in circulatory arrest-brain injury
Burd K08HD073315, IL-1β regulation of perinatal brain injury
Fatemi K08 NS063956, Study of White Matter Development in a Rodent Model of Perinatal Brain Injury
Fatemi Brian’s Hope Foundation, Nanodendrimer-based targeted delivery of the N-acetylcysteine for adrenoleukodystrophy – a pilot study to determine feasibility of clinical translation
Hardwick R01NS083373, Mechanisms of neurodegeneration 
Jonas R01HL104173, Protection of developing white matter during cardiac surgery 
Kadam R21HD073105, Neonatal ischemic seizures: Age and gender suspectibility to refractoriness
Kannan R01 HD069562, Mechanisms and novel therapy in intrauterine inflammation induced brain injury
Laterra R01NS076759, Suppression of Glioblastoma Stem Cells by Kruppel-Like Factor 9
Laterra R01CA95704, Mechanisms of chemo/radioresistance in human gliomas 
Laterra R01CA129192, Neutralizing Anti-HGF mAbs and CNS malignancy 
Maegawa R21NS071535, A HTS assay to identify molecular probes for arylsulfatase A 
Marsh-Armstrong R01EY10157592, Optic Nerve Synucleinopathy in Glaucoma and the Function of gamma-Synuclein
Naidu R01FD004247, PH2 Study of Dextromethorpan in the treatment of Rett Syndrome
Northington R01HD070996, Mechanisms of hypothermic neuroprotection in neonates
Pelled R01NS072171, The role of transcallosal pathway to neuroplasticity following nerve injury
Pelled/Gilad R01NS079288, Adaptive control of epileptic seizures using a genetically encoded sensor
Scafidi K01NS069815, Metabolic dysfunction and neuroprotection after pediatric head injury 
Song R21EB020905, In vivo molecular MR imaging of inflammation using NSAIDs as CEST
Vernon K08HD073492, Metabolic studies in disorders of branch chain amino acid metabolism
Wagner U54 HD060848, Biomarkers for Therapy of FSHD
Watkins R21NS091988, Drug discovery for X-linked adrenoleukodystrophy 
Wilson U54HD079123, Research Component (IDDRC)
Yau R01EY014596, Melanopsin photoreception and signaling
Xia R01NS091165, Methyl-CpG-dependent transcription factor function in human gliomas
Zhou R21 EB015555, Molecular MRI of radiation necrosis in preclinical models
Neuroimaging Core  
Bembea/Moler U01HL094345, Therapeutic Hypothermia After Pediatric Cardiac Arrest: A Randomized Controlled Trial (THAPCA)
Burd K08HD073315, IL-1β regulation of perinatal brain injury
Cheng K01AA020873, Neuroimaging of eyeblink conditioning in subjects with alcohol use disorders
Edden R21MH098228, Dysfunction of sensory inhibition in Autism
Everett R01HD68446, GFAP biomarker of whole body cooling outcome and efficacy in the neonate with HIE
Fatemi K08 NS063956, Study of White Matter Development in a Rodent Model of Perinatal Brain Injury

Findling

R01MJ073967, Longitudinal assessment of manic symptoms 
Frazier R01MH083320, A knowledge environment for neuroimaging in child psychiatry
Hoon UL1-TR001079, NBRU: Interrelationships among quantitative measures of white matter injury, sensorimotor function and learning profiles in children with CP
Hoon/Barker P41RR015241 Sub-Project: Diffusion Tensor Imaging in Children with Cerebral Palsy
Jonas R01HL104173, Protection of developing white matter during cardiac surgery 
Kannan R01 HD069562, Mechanisms and novel therapy in intrauterine inflammation induced brain injury
Lin UL1-TR001079, NBRU: Noninvasive imaging and functional correlation of intracranial pial angiomatosis (SWS)
Mahone R01HD068425, Development of ADHD in Preschool Children: Neuroimaging and Behavioral Correlates 
Mahone UL1-TR001079, NBRU: Neuroimaging of motor stereotypies in children with autism
Mostofsky R01MH078160, Anamalous motor physiology in ADHD
Mostofsky R01MH085328 Neurology of deficient response control in ADHD
Mostofsky UL1-TR001079, NBRU: Tourette syndrome neuroimaging consortium pilot
Northington R01HD070996, Mechanisms of hypothermic neuroprotection in neonates
Pelled R01NS072171, The role of transcallosal pathway to neuroplasticity following nerve injury
Pelled/Gilad R01NS079288, Adaptive control of epileptic seizures using a genetically encoded sensor
Rosch K23MH101322 Delay dis in children with ADHD
Suskauer K23HD061611, Neural basis of recovery of inhibitory control after pediatric TBI
Suskauer R21HD080378 Somatosensory processing-assessing youth sport-related concussion and recovery
Suskauer UL1-TR001079, NBRU: Neural Basis of Impairments in Response Inhibition and Processing Speed
Zhang R01HD074593, Imaging neonatal hypoxic ischemic injury
Zhang R01NS070909, Mapping gene expression in the developing mouse brain
Zhou R21 EB015555, Molecular MRI of radiation necrosis in preclinical models
Behavior Science Core  
Arenivas

UL1-TR001079, NBRU: Neuroimaging and Neurobehavioral Outcomes of Pediatric Neuromyelitis Optica: A Pilot Study 

Atkinson UL1-TR001079, NBRU: Chronic Kidney Disease in Chldren Study (CkiD)
Bastian R01HD040289, Mechanisms and Rehabilitation of Cerebellar Ataxia
Bastian R01HD048741, Human Locomotor Plasticity in Health and Disease)
Bembea/Moler U01HL094345, Therapeutic Hypothermia After Pediatric Cardiac Arrest: A Randomized Controlled Trial (THAPCA)
Bembea 5U01NS081041-02, Approaches and Decisions in Acute Pediatric TBI Trial (ADAPT)
Bembea 1KL2RR025006-01; K23NS076674, Activation of Coagulation in Pediatric Patients Undergoing Extracorporeal Membrane Oxygenation (ECMO) 
Boger R01AI093701, Novel Artemisinin derivatives for cytomegalovirus therapy

Budimirovic/Brasic

R21MH107870, Glutamine receptor function in Fragile X syndrome
Capone UL1-TR001079, NBRU: Depression and sleep disorders in adolescents and young adults with Down syndrome
Celnik R01 HD053793, Novel Strategies to enhance motor function after stroke
Celnik R01HD073147, Understanding motor behavior after stroke 
Celnik UL1-TR001079, NBRU: Effects of excitation and inhibition of the temporo-parietal cortex via tDCS on reading performance in children with dyslexia
Chib K12 HD073945, Reward mechanisms for motor control.  
Cohen K99MH102349, Large scale organization during cognitive control in ADHD
Germain-Lee R21HD078864, The role of G protein-coupled signaling in neurocognitive and psychosocial abnormalities
Hagopian P01HD055456 Translational analyses of chronic aberrant behavior across the life span
DeLeon P01HD055456 Translational analyses of chronic aberrant behavior across the life span. Project 2: Behavioral economics and the analysis of CAB
Dooley R01HD074944-01, Optimizing Treatment to Improve TBM Outcomes in Children: The TBM KIDS Trial
Edden R21MH098228, Dysfunction of sensory inhibition in Autism
Ewen K23NS073626, EEG-Based Assessment of Functional Connectivity in Autism
Ewen R21NS091569, Direct examination of imitation based learning in Autism
Gipson 2K12NS001696, Rapalogues for Autism Phenotype in TSC (RAPT)
DeLeon R01HD049753 Behavioral economics in MRDD and behavior disorders
Hagopian P01HD055456 Translational analyses of chronic aberrant behavior across the lift span: Project 3: Treatment generalization and ncontingency coherence
Hamosh UL1-TR001079, NBRU: Maternal hyperphenylalanine (Phe) control in pregnancy w/cognitive and behavioral outcomes in offspring
Hoon UL1-TR001079, NBRU: Interrelationships among quantitative measures of white matter injury, sensorimotor function and learning profiles in children with CP
Hoon/Barker P41RR015241 Sub-Project: Diffusion Tensor Imaging in Children with Cerebral Palsy
Krauss/Meador, Kimford U01NS038455, Maternal outcomes and neurodevelopmental effects of antiepileptic drugs (MONEAD)

Krinsky-McHale/Silverman

P01HD035897, Aging and dementia in adults with Down syndrome:  Subproject 2
Loring PCORI Contract #527, Cognitive AED outcomes in pediatric localization related epilepsy (COPE)
Mahone R01HD068425, Development of ADHD in Preschool Children: Neuroimaging and Behavioral Correlates 
Mahone UL1-TR001079, NBRU: Neuroimaging of motor stereotypies in children with autism
Mostofsky R01MH078160, Anamalous motor physiology in ADHD
Mostofsky R01MH085328 Neurology of deficient response control in ADHD
Mostofsky UL1-TR001079, NBRU: Tourette syndrome neuroimaging consortium pilot
Naidu R01FD004247, PH2 Study of Dextromethorpan in the treatment of Rett Syndrome
Reinblatt K23MH0830000-01, Pediatric Binge Eating, Impulsivity and Treatment
Robertson 5U01NS081041-02, Approaches and Decisions in Acute Pediatric TBI (ADAPT)
Rosch K23MH101322 Delay dis in children with ADHD
Seymour K23MH107734, Neurobehavioral correlates of frustration in ADHD
Silverman P01HD035897, Aging and dementia in adults with Down syndrome
Schupf/Silverman/Lott U01AG051412, Biomarkers of Alzheimer’s disease in adults with Down syndrome
Schwarz UL1-TR001079, NBRU: A prospective database of infants with cholestasis
Schwarz UL1-TR001079, NBRU: Biliary Artesia Research Consortium (BARC)
Suskauer K23HD061611, Neural basis of recovery of inhibitory control after pediatric TBI
Smith R01AG0388893, Logitudinal imaging of neuropsychiatric symptoms in mild cognitive impairment
Suskauer R21HD080378 Somatosensory processing-assessing youth sport-related concussion and recovery
Suskauer UL1-TR001079, NBRU: Neural Basis of Impairments in Response Inhibition and Processing Speed

Cost Sharing

Funding for Core services is shared between the IDDRC and the other sources of support for approved projects/investigators. The intellectual, financial, and physical resources of home departments, the IDDRC, and investigators’ own grants are combined to produce a productive enterprise that would be prohibitively expensive for any one of these components to operate independently. Because needs and resources vary considerably across individually supported projects, cost sharing plans are developed on a case-by-case basis, taking into consideration both the needs of the project and the resources available.

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