Quantitative analysis of brain pathology based on MRI and brain atlases--applications for cerebral palsy.

TitleQuantitative analysis of brain pathology based on MRI and brain atlases--applications for cerebral palsy.
Publication TypeJournal Article
Year of Publication2011
AuthorsFaria AV, Hoon A, Stashinko E, Li X, Jiang H, Mashayekh A, Akhter K, Hsu J, Oishi K, Zhang J, Miller MI, van Zijl PCM, Mori S
JournalNeuroImage
Volume54
Issue3
Pagination1854-61
Date Published2011 Feb 1
Abstract

We have developed a new method to provide a comprehensive quantitative analysis of brain anatomy in cerebral palsy patients, which makes use of two techniques: diffusion tensor imaging and automated 3D whole brain segmentation based on our brain atlas and a nonlinear normalization technique (large-deformation diffeomorphic metric mapping). This method was applied to 13 patients and normal controls. The reliability of the automated segmentation revealed close agreement with the manual segmentation. We illustrate some potential applications for individual characterization and group comparison. This technique also provides a framework for determining the impact of various neuroanatomic features on brain functions.

DOI10.1097/CCM.0b013e31825457b8
Alternate JournalNeuroimage