Plasticity and mTOR: towards restoration of impaired synaptic plasticity in mTOR-related neurogenetic disorders.

TitlePlasticity and mTOR: towards restoration of impaired synaptic plasticity in mTOR-related neurogenetic disorders.
Publication TypeJournal Article
Year of Publication2012
AuthorsGipson TT, Johnston MV
JournalNeural plasticity
Volume2012
Pagination486402
Date Published2012
Abstract

To review the recent literature on the clinical features, genetic mutations, neurobiology associated with dysregulation of mTOR (mammalian target of rapamycin), and clinical trials for tuberous sclerosis complex (TSC), neurofibromatosis-1 (NF1) and fragile X syndrome (FXS), and phosphatase and tensin homolog hamartoma syndromes (PTHS), which are neurogenetic disorders associated with abnormalities in synaptic plasticity and mTOR signaling.

DOI10.1155/2012/486402
Alternate JournalNeural Plast.