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Multiparametric MRI correlates of sensorimotor function in the spinal cord in multiple sclerosis.
|Title||Multiparametric MRI correlates of sensorimotor function in the spinal cord in multiple sclerosis.|
|Publication Type||Journal Article|
|Year of Publication||2013|
|Authors||Oh J, Zackowski K, Chen M, Newsome S, Saidha S, Smith SA, Diener-West M, Prince J, Jones CK, van Zijl PCM, Calabresi PA, Reich DS|
|Journal||Multiple sclerosis (Houndmills, Basingstoke, England)|
|Date Published||2013 Apr|
Spinal cord (SC) pathology is a major contributor to clinical disability in multiple sclerosis (MS). Conventional magnetic resonance imaging (MRI), specifically SC-MRI lesion load measures that include lesion count and volume, demonstrate only a modest relationship with the clinical status of MS patients. Although SC cross-sectional area (CSA) correlates better with clinical dysfunction than MRI lesion count, SC atrophy likely signifies irreversible tissue loss. Using quantitative MRI indices sensitive to early and late microstructural changes in the spinal cord, we searched for the presence of better correlations between MRI measures and clinical status in MS.
|Alternate Journal||Mult. Scler.|