The Effect of Dantonic Pill on β -Catenin Expression in a Rat Model of Streptozotocin-Induced Early Stage of Diabetic Nephropathy.

TitleThe Effect of Dantonic Pill on β -Catenin Expression in a Rat Model of Streptozotocin-Induced Early Stage of Diabetic Nephropathy.
Publication TypeJournal Article
Year of Publication2013
AuthorsShuhong Z, Hongjun L, Bo C, Li X, Bingyin S
JournalJournal of diabetes research
Volume2013
Pagination848679
Date Published2013
Abstract

Diabetic nephropathy (DN) is one of the most common causes of end-stage renal failure. This study was performed to determine the effect of Dantonic Pill (DP) treatment on β -catenin expression in a rat model of streptozotocin- (STZ-) induced early-stage DN, with irbesartan treatment as a positive control. Including an analysis of the general metabolic index and renal function, immunohistochemical staining and reverse transcription real-time PCR for β -catenin were performed in the renal cortex of the rat models every 4 weeks. After the treatments of DP and irbesartan, the albuminuria level, kidney weight/body weight, and thickness of the glomerular basement membrane were decreased, but the expression of β -catenin was not downregulated in the renal cortex. The effective drug target of DP to ameliorate albuminuria and renal hypertrophy should not inhibit the upregulated expression of β -catenin in rats with STZ-induced early-stage diabetic damage.

DOI10.1155/2013/979702
Alternate JournalJ Diabetes Res