Is there a link between older fathers and SWS?

OCTOBER 24, 2016

Question: Several recent articles cite new research demonstrating that children of older men are more likely to inherit a gene mutation. My child has Sturge-Weber syndrome, which I know is caused by a gene mutation. The child’s father is older. Is there a link, or could there be a link between older fathers and SWS?

Answer:
The GNAQ gene mutation in SWS is a somatic mutation; it occurs after the egg and sperm come together. It is not inherited from the mother or father. The mutation is only found in some cells of the body and mostly in the affected area of the body.

The Hunter Nelson Center for Sturge-Weber Syndrome has evaluated hundreds of children with SWS. In the vast majority of cases, neither parent is considered to be older. There is not likely to be a link between older fathers and SWS. If you have further questions about this, be sure to talk with your neurologist or other physician. More information about the somatic mutation can also be found on our website. To learn more, view this video, in which Dr. Anne Comi shares a message about news that the gene mutation causing Sturge-Weber syndrome and port-wine birthmarks was discovered by a team at Kennedy Krieger.

Check back for new posts and up-to-date information from Sturge-Weber syndrome expert Dr. Anne Comi. 

Check back for new posts and up-to-date information from Sturge-Weber syndrome expert Dr. Anne Comi.

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