Peter B. Barker, D.Phil.

Peter B. Barker, D.Phil.'s picture
Research Scientist

Johns Hopkins University School of Medicine
600 North Wolfe St., Park 367B
Baltimore, MD 21287
Phone: (410) 955-1740
Email: pbarker2@jhmi.edu

Dr. Barker is a research scientist who works to develop magnetic resonance imaging (MRI) and spectroscopy (MRS) techniques for evaluating diseases of the human central nervous system. He also conducts research studies to determine the utility of these new techniques, particularly in the understanding and diagnosis of neurological, psychiatric and oncological diseases. At the Kennedy Krieger Institute, Dr. Barker is actively involved in research studies currently being performed at the FM Kirby Center for Functional Brain Imaging.

Biographical Sketch: 

Dr. Barker attended Oxford University in the United Kingdom, where he received a Bachelor's of Arts degree in chemistry and a Doctor of Philosophy degree in physical chemistry. He conducted his post-doctoral research in magnetic resonance imaging and spectroscopy at the California Institute of Technology. He has been a faculty member in the Department of Radiology at Johns Hopkins since 1989. He is currently a professor of radiology and oncology at Johns Hopkins, and a research scientist at the Kennedy Krieger Institute.

Research Summary: 

Dr. Barker's current research interests include developing methods to non-invasively map out neurochemical and neurotransmitter levels in the brain in patients with brain tumors, infectious diseases, neurometabolic diseases, neurodegenerative diseases, schizophrenia and other psychiatric diseases using MRS. He is also interested in MRI techniques that can be used to non-invasively measure blood flow in the brain. A particular focus at present is to develop human MRI and MRS techniques for use at very high magnetic field strengths (7 Tesla). Dr. Barker collaborates on various MRI/MRS research projects with neurologists, neurosurgeons, oncologists and psychiatrists at Johns Hopkins and the Kennedy Krieger Institute.

Research Publications:

Zhou J, Zhu H, Lim M, Blair L, Quinones-Hinojosa A, Messina SA, Eberhart CG, Pomper MG, Laterra J, Barker PB, van Zijl PC, Blakeley JO (2013). Three-dimensional amide proton transfer MR imaging of gliomas: Initial experience and comparison with gadolinium enhancement. J Magn Reson Imaging. 38(5), 1119-28. Abstract
Foerster BR, Pomper MG, Callaghan BC, Petrou M, Edden RA, Mohamed MA, Welsh RC, Carlos RC, Barker PB, Feldman EL (2013). An imbalance between excitatory and inhibitory neurotransmitters in amyotrophic lateral sclerosis revealed by use of 3-T proton magnetic resonance spectroscopy. JAMA Neurol. 70(8), 1009-16. Abstract
Unschuld PG, Edden RA, Carass A, Liu X, Shanahan M, Wang X, Oishi K, Brandt J, Bassett SS, Redgrave GW, Margolis RL, van Zijl PC, Barker PB, Ross CA (2012). Brain metabolite alterations and cognitive dysfunction in early Huntington's disease. Mov Disord. 27(7), 895-902. Abstract
Landman BA, Huang AJ, Gifford A, Vikram DS, Lim IA, Farrell JA, Bogovic JA, Hua J, Chen M, Jarso S, Smith SA, Joel S, Mori S, Pekar JJ, Barker PB, Prince JL, van Zijl PC (2011). Multi-parametric neuroimaging reproducibility: a 3-T resource study. Neuroimage. 54(4), 2854-66. Abstract
Horská A, Farage L, Bibat G, Nagae LM, Kaufmann WE, Barker PB, Naidu S (2009). Brain metabolism in Rett syndrome: age, clinical, and genotype correlations. Ann Neurol. 65(1), 90-7. Abstract
Smith SA, Edden RA, Farrell JA, Barker PB, Van Zijl PC (2008). Measurement of T1 and T2 in the cervical spinal cord at 3 tesla. Magn Reson Med. 60(1), 213-9. Abstract
Bonekamp D, Nagae LM, Degaonkar M, Matson M, Abdalla WM, Barker PB, Mori S, Horská A (2007). Diffusion tensor imaging in children and adolescents: reproducibility, hemispheric, and age-related differences. Neuroimage. 34(2), 733-42. Abstract
Halbower AC, Degaonkar M, Barker PB, Earley CJ, Marcus CL, Smith PL, Prahme MC, Mahone EM (2006). Childhood obstructive sleep apnea associates with neuropsychological deficits and neuronal brain injury. PLoS Med. 3(8), e301. Abstract
Barreiro CJ, Williams JA, Fitton TP, Lange MS, Blue ME, Kratz L, Barker PB, Degaonkar M, Gott VL, Troncoso JC, Johnston MV, Baumgartner WA (2006). Noninvasive assessment of brain injury in a canine model of hypothermic circulatory arrest using magnetic resonance spectroscopy. Ann Thorac Surg. 81(5), 1593-8. Abstract
Dubey P, Fatemi A, Huang H, Nagae-Poetscher L, Wakana S, Barker PB, van Zijl P, Moser HW, Mori S, Raymond GV (2005). Diffusion tensor-based imaging reveals occult abnormalities in adrenomyeloneuropathy. Ann Neurol. 58(5), 758-66. Abstract
Nagae-Poetscher LM, Bonekamp D, Barker PB, Brant LJ, Kaufmann WE, Horská A (2004). Asymmetry and gender effect in functionally lateralized cortical regions: a proton MRS imaging study. J Magn Reson Imaging. 19(1), 27-33. Abstract
Pizzini F, Fatemi AS, Barker PB, Nagae-Poetscher LM, Horská A, Zimmerman AW, Moser HW, Bibat G, Naidu S (2003). Proton MR spectroscopic imaging in Pelizaeus-Merzbacher disease. AJNR Am J Neuroradiol. 24(8), 1683-9. Abstract
Horská A, Kaufmann WE, Brant LJ, Naidu S, Harris JC, Barker PB (2002). In vivo quantitative proton MRSI study of brain development from childhood to adolescence. J Magn Reson Imaging. 15(2), 137-43. Abstract

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