Ultra-High Field 11.7 Tesla Pre-Clinical MRI System with First 500 MHz CryoProbe in North America to be Installed at Kennedy Krieger Institute

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July 22, 2010
first ultra-high field MRI CryoProbe in North America will be installed at the F.M. Kirby Research Center

The first ultra-high field MRI CryoProbe in North America will be installed at the F.M. Kirby Research Center for Functional Brain Imaging at the Kennedy Krieger Institute in Baltimore, MD. Supported by an American Recovery and Reinvestment Act (ARRA) award to Dr. Peter van Zijl, Director of the Center, the 500 MHz MRI CryoProbe is part of Bruker BioSpin Corporation's ultra-high field preclinical MRI BioSpec® system that includes an 11.7 T UltraShield Refrigerated (USR™) magnet and AVANCE™ III electronics. The MRI CryoProbe offers a leap in sensitivity that will enable even higher resolution imaging of microscopic structures in vivo, furthering the exploration of neurodegenerative diseases in small animals. Sharing a commitment to accelerate novel research, the Kennedy Krieger Institute, John Hopkins University School of Medicine and Bruker have signed a research collaboration agreement to develop advanced imaging techniques for future preclinical imaging applications.

Based on very low temperature, closed-cycle cooled RF-coils and preamplifiers, the unique Bruker MRI CryoProbe delivers an increase in signal-to-noise ratio (SNR) of a factor of 2.5x over equivalent room temperature RF-coils in routine MRI applications.

"We are very excited to add this 500 MHz MRI CryoProbe technology as well as the multi-channel transmit system that comes with it. This will allow us to push the boundaries of what is possible with MRI and MRS in the years to come. The close collaboration with Bruker will allow us to stay state-of-the-art with MR hardware and software and to explore novel preclinical imaging technologies," said Dr. Peter van Zijl, Director of the F.M. Kirby Research Center for Functional Brain Imaging at Kennedy Krieger Institute.

Dr. Roy Gordon, Vice President of Bruker BioSpin Corporation, added, "We are pleased to take the next step in MRI CryoProbe technology, now up to 500 MHz, having already proven its exceptional advantages in neuro and cardio preclinical imaging at 300 and 400 MHz. We look forward to seeing the benefits and insights into neurodegenerative disease in animal models that will be gained from this new technology".

About Bruker

For more information on MRI CryoProbe, please visit www.bruker.com/mricryoprobe.

About Kennedy Krieger Institute

Internationally recognized for improving the lives of children and adolescents with disorders and injuries of the brain and spinal cord, the Kennedy Krieger Institute in Baltimore, MD serves more than 13,000 individuals each year through inpatient and outpatient clinics, home and community services and school-based programs. Kennedy Krieger provides a wide range of services for children with developmental concerns mild to severe, and is home to a team of investigators who are contributing to the understanding of how disorders develop while pioneering new interventions and earlier diagnosis. For more information on Kennedy Krieger Institute, visit www.kennedykrieger.org.

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