Synthesis and proton NMR spectroscopy of intra-vesicular gamma-aminobutyric acid (GABA).

Mark McIntosh,'s picture
PubMed URL: 
http://www.ncbi.nlm.nih.gov/pubmed/24109882
Author: 
Kohane DS
Author List: 
Wang LY
Tong R
Kohane DS
Journal: 
Conf Proc IEEE Eng Med Biol Soc
PubMed ID: 
24109882
Pagination: 
1093-5
Volume: 
2013
Abstract: 
We report the synthesis of vesicles containing gamma-aminobutyric acid (GABA), and their proton nuclear magnetic resonance ((1)H NMR) spectra. These vesicles were constructed to more closely mimic the intracellular environment wherein GABA exists. For this study, these GABA-containing vesicles were examined under (1)H NMR as a potential platform for future studies on the differences between aqueous phantoms, ex vivo brain extracts, and in vivo magnetic resonance spectroscopy results. We found that intra-vesicular GABA faithfully yielded the chemical shifts and J-coupling constants of free aqueous GABA, alongside the chemical shift signals of the vesicle wall.
Published Date: 
January, 2013

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