(15)N Heteronuclear Chemical Exchange Saturation Transfer MRI.

Mark McIntosh,'s picture
PubMed URL: 
http://www.ncbi.nlm.nih.gov/pubmed/27548755
Author: 
van Zijl PC
Author List: 
Zeng H
Xu J
Yadav NN
McMahon MT
Harden B
Frueh D
van Zijl PC
Journal: 
J Am Chem Soc
PubMed ID: 
27548755
Pagination: 
11136-9
Volume: 
138
Issue: 
35
Abstract: 
A two-step heteronuclear enhancement approach was combined with chemical exchange saturation transfer (CEST) to magnify (15)N MRI signal of molecules through indirect detection via water protons. Previous CEST studies have been limited to radiofrequency (rf) saturation transfer or excitation transfer employing protons. Here, the signal of (15)N is detected indirectly through the water signal by first inverting selectively protons that are scalar-coupled to (15)N in the urea molecule, followed by chemical exchange of the amide proton to bulk water. In addition to providing a small sensitivity enhancement, this approach can be used to monitor the exchange rates and thus the pH sensitivity of the participating (15)N-bound protons.
Published Date: 
September, 2016

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