Protective effect of erythropoietin in neonatal hypoxic ischemia in mice.

Mark McIntosh,'s picture
PubMed URL: 
http://www.ncbi.nlm.nih.gov/pubmed/14512852
Author: 
Wilson MA
Author List: 
Matsushita H
Johnston MV
Lange MS
Wilson MA
Journal: 
Neuroreport
PubMed ID: 
14512852
Pagination: 
1757-61
Volume: 
14
Issue: 
13
Abstract: 
The effect of systemic erythropoietin pretreatment on hypoxic ischemic injury was examined in neonatal mice. Injury was significantly less in cortex, hippocampus, striatum and thalamus of erythropoietin-treated animals (5 U/g vs vehicle) 24 h after hypoxic ischemia and in all of these regions except hippocampus at 7 days. Activated caspase-3- and activated NFkappaB-immunoreactive neurons were observed in the injured areas; these areas were smaller in the erythropoietin group. To our knowledge, this is the first report demonstrating persistent neuroprotective effects of erythropoietin in neonatal mice.
Published Date: 
September, 2003

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