Validity of the Six Minute Walk Test in Facioscapulohumeral Muscular Dystrophy.

Mark McIntosh,'s picture
PubMed URL:
Statland JM
Author List: 
Eichinger K
Heatwole C
Heininger S
Stinson N
Matichak Stock C
Grosmann C
Wagner KR
Tawil R
Statland JM
FSHD Clinical Trials Research Network
Muscle Nerve
PubMed ID: 
In preparation for future clinical trials, we determined the reliability, relationship to measures of disease severity, and consistency across sites of the 6 minute walk test (6MWT) in patients with facioscapulohumeral muscular dystrophy (FSHD).Genetically defined and clinically affected FSHD participants at 2 sites performed the 6MWT, the Timed Up and Go, and the 30 foot Go/Timed 10 meter test as measures of mobility using standard procedures.Eight-six participants representing the full range of severity performed the 6MWT. The mean 6MWT distance was 404.3 meters (SD 123.9), with no difference between sites. The 6MWT was reliable (n=25, intraclass correlation coefficient= 0.99) and demonstrated moderate to strong correlations with lower extremity strength, functional outcomes, and FSHD Clinical Score.The 6MWT is reliable and is associated with other measures of FSHD disease severity. Future directions include assessing its sensitivity to disease progression. This article is protected by copyright. All rights reserved.
Published Date: 
July, 2016

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