Representation of internal models of action in the autistic brain.

Mark McIntosh,'s picture
PubMed URL: 
http://www.ncbi.nlm.nih.gov/pubmed/19578379
Author: 
Shadmehr R
Author List: 
Haswell CC
Izawa J
Dowell LR
Mostofsky SH
Shadmehr R
Journal: 
Nat Neurosci
PubMed ID: 
19578379
Pagination: 
970-2
Volume: 
12
Issue: 
8
Abstract: 
Children with autism spectrum disorder (ASD) have deficits in motor control, imitation and social function. Does a dysfunction in the neural basis of representing internal models of action contribute to these problems? We measured patterns of generalization as children learned to control a novel tool and found that the autistic brain built a stronger than normal association between self-generated motor commands and proprioceptive feedback; furthermore, the greater the reliance on proprioception, the greater the child's impairments in social function and imitation.
Published Date: 
August, 2009

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