Artificial reporter gene providing MRI contrast based on proton exchange.

Mark McIntosh,'s picture
PubMed URL: 
http://www.ncbi.nlm.nih.gov/pubmed/17259977
Author: 
van Zijl PC
Author List: 
Gilad AA
McMahon MT
Walczak P
Winnard PT Jr
Raman V
van Laarhoven HW
Skoglund CM
Bulte JW
van Zijl PC
Journal: 
Nat Biotechnol
PubMed ID: 
17259977
Pagination: 
217-9
Volume: 
25
Issue: 
2
Abstract: 
Existing magnetic resonance reporter genes all rely on the presence of (super)paramagnetic substances and employ water relaxation to gain contrast. We designed a nonmetallic, biodegradable, lysine rich-protein (LRP) reporter, the prototype of a potential family of genetically engineered reporters expressing artificial proteins with frequency-selective contrast. This endogenous contrast, based on transfer of radiofrequency labeling from the reporter's amide protons to water protons, can be switched on and off.
Published Date: 
February, 2007

Bradley L. Schlaggar, M.D., Ph.D., Named President and CEO of Kennedy Krieger Institute

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