Natural D-glucose as a biodegradable MRI relaxation agent.

Mark McIntosh,'s picture
PubMed URL: 
http://www.ncbi.nlm.nih.gov/pubmed/24975029
Author: 
van Zijl PC
Author List: 
Yadav NN
Xu J
Bar-Shir A
Qin Q
Chan KW
Grgac K
Li W
McMahon MT
van Zijl PC
Journal: 
Magn Reson Med
PubMed ID: 
24975029
Pagination: 
823-8
Volume: 
72
Issue: 
3
Abstract: 
Demonstrate applicability of natural D-glucose as a T2 MRI contrast agent.D-glucose solutions were prepared at multiple concentrations and variable pH. The relaxation rate (R2  = 1/T2 ) was measured at 3, 7, and 11.7 T. Additional experiments were performed on blood at 11.7 T. Also, a mouse was infused with D-glucose (3.0 mmol/kg) and dynamic T2 weighted images of the abdomen acquired.The transverse relaxation rate depended strongly on glucose concentration and solution pH. A maximum change in R2 was observed around physiological pH (pH 6.8-7.8). The transverse relaxivities at 22°C (pH 7.3) were 0.021, 0.060, and 0.077 s(-1) mM(-1) at 3.0, 7.0, and 11.7 T, respectively. These values showed good agreement with expected values from the Swift-Connick equation. There was no significant dependence on glucose concentration or pH for T1 and the diffusion coefficient for these solutions. The transverse relaxivity in blood at 11.7 T was 0.09 s(-1) mM(-1) . The dynamic in vivo experiment showed a 10% drop in signal intensity after glucose infusion followed by recovery of the signal intensity after about 50-100 s.Glucose can be used as a T2 contrast agent for MRI at concentrations that are already approved for human use.
Published Date: 
September, 2014

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