Superficially located white matter structures commonly seen in the human and the macaque brain with diffusion tensor imaging.

Mark McIntosh,'s picture
PubMed URL: 
http://www.ncbi.nlm.nih.gov/pubmed/22432953
Author: 
Mori S
Author List: 
Oishi K
Huang H
Yoshioka T
Ying SH
Zee DS
Zilles K
Amunts K
Woods R
Toga AW
Pike GB
Rosa-Neto P
Evans AC
van Zijl PC
Mazziotta JC
Mori S
Journal: 
Brain Connect
PubMed ID: 
22432953
Pagination: 
37-47
Volume: 
1
Issue: 
1
Abstract: 
The white matter of the brain consists of fiber tracts that connect different regions of the brain. Among these tracts, the intrahemispheric cortico-cortical connections are called association fibers. The U-fibers are short association fibers that connect adjacent gyri. These fibers were thought to work as part of the cortico-cortical networks to execute associative brain functions. However, their anatomy and functions have not been documented in detail for the human brain. In past studies, U-fibers have been characterized in the human brain with diffusion tensor imaging (DTI). However, the validity of such findings remains unclear. In this study, DTI of the macaque brain was performed, and the anatomy of U-fibers was compared with that of the human brain reported in a previous study. The macaque brain was chosen because it is the most commonly used animal model for exploring cognitive functions and the U-fibers of the macaque brain have been already identified by axonal tracing studies, which makes it an ideal system for confirming the DTI findings. Ten U-fibers found in the macaque brain were also identified in the human brain, with a similar organization and topology. The delineation of these species-conserved white matter structures may provide new options for understanding brain anatomy and function.
Published Date: 
January, 2011

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