3D current source density imaging based on the acoustoelectric effect: a simulation study using unipolar pulses.

Mark McIntosh,'s picture
PubMed URL: 
http://www.ncbi.nlm.nih.gov/pubmed/21628774
Author: 
He B
Author List: 
Yang R
Li X
Liu J
He B
Journal: 
Phys Med Biol
PubMed ID: 
21628774
Pagination: 
3825-42
Volume: 
56
Issue: 
13
Abstract: 
It is of importance to image electrical activity and properties of biological tissues. Recently hybrid imaging modality combing ultrasound scanning and source imaging through the acoustoelectric (AE) effect has generated considerable interest. Such modality has the potential to provide high spatial resolution current density imaging by utilizing the pressure-induced AE resistivity change confined at the ultrasound focus. In this study, we investigate a novel three-dimensional (3D) ultrasound current source density imaging approach using unipolar ultrasound pulses. Utilizing specially designed unipolar ultrasound pulses and by combining AE signals associated to the local resistivity changes at the focusing point, we are able to reconstruct the 3D current density distribution with the boundary voltage measurements obtained while performing a 3D ultrasound scan. We have shown in computer simulation that using the present method it is feasible to image with high spatial resolution an arbitrary 3D current density distribution in an inhomogeneous conductive media.
Published Date: 
July, 2011

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