Dextromethorphan protects male but not female mice with brain ischemia.

Mark McIntosh,'s picture
PubMed URL: 
http://www.ncbi.nlm.nih.gov/pubmed/16951577
Author: 
Wilson MA
Author List: 
Comi AM
Highet BH
Mehta P
Hana Chong T
Johnston MV
Wilson MA
Journal: 
Neuroreport
PubMed ID: 
16951577
Pagination: 
1319-22
Volume: 
17
Issue: 
12
Abstract: 
The non-competitive N-methyl-D-aspartate receptor antagonist dextromethorphan is protective against some types of brain injury. Unilateral carotid ligation in postnatal day 12 CD1 mice produces ischemic brain injury. To evaluate the neuroprotective potential of dextromethorphan against ischemic injury in the immature brain, seven litters of postnatal day 12 CD1 mice received either dextromethorphan or vehicle after a unilateral carotid ligation. Only the male pups were protected, and brain injury was unchanged in the female pups treated with dextromethorphan. These results suggest that dextromethorphan neuroprotection against ischemic injury in the immature brain is sex-dependent.
Published Date: 
August, 2006

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