Parental reports on early language and motor milestones in fragile X syndrome with and without autism spectrum disorders.

Mark McIntosh,'s picture
PubMed URL: 
http://www.ncbi.nlm.nih.gov/pubmed/23249372
Author: 
Johnston MV
Author List: 
Hinton R
Budimirovic DB
Marschik PB
Talisa VB
Einspieler C
Gipson T
Johnston MV
Journal: 
Dev Neurorehabil
PubMed ID: 
23249372
Pagination: 
58-66
Volume: 
16
Issue: 
1
Abstract: 
This study examined features of early language and motor milestones in children with fragile X syndrome (FXS) and contrasted these features with a diagnosis of Autism Spectrum Disorder (ASD) later in life in these children.We retrospectively examined parental report of age of onset for walking and first words for primarily boys with FXS, both with ASD (FXS + ASD) and FXS-only. The diagnosis of ASD was established by DSM-IV criteria, which were complemented by the ADOS. The age of onset was analyzed as a continuous and categorical variable, which were compared to the upper limit of typically developing children.Individuals with FXS-only are more delayed in the onset of first words than first walks. The finding represents a pattern suggesting a continuum as robustly demonstrated in individuals with FXS + ASD vs. FXS-only.Our results support validity of FXS + ASD co-morbidity as a distinct phenotype in individuals with FXS.
Published Date: 
January, 2013

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