Quantitative description of the asymmetry in magnetization transfer effects around the water resonance in the human brain.

Mark McIntosh,'s picture
PubMed URL: 
http://www.ncbi.nlm.nih.gov/pubmed/17899597
Author: 
Zhou J
Author List: 
Hua J
Jones CK
Blakeley J
Smith SA
van Zijl PC
Zhou J
Journal: 
Magn Reson Med
PubMed ID: 
17899597
Pagination: 
786-93
Volume: 
58
Issue: 
4
Abstract: 
Magnetization transfer (MT) imaging provides a unique method of tissue characterization by capitalizing on the interaction between solid-like tissue components and bulk water. We used a continuous-wave (CW) MT pulse sequence with low irradiation power to study healthy human brains in vivo at 3 T and quantified the asymmetry of the MT effects with respect to the water proton frequency. This asymmetry was found to be a difference of approximately a few percent from the water signal intensity, depending on both the RF irradiation power and the frequency offset. The experimental results could be quantitatively described by a modified two-pool MT model extended with a shift contribution for the semisolid pool with respect to water. For white matter, this shift was fitted to be 2.34 +/- 0.17 ppm (N = 5) upfield from the water signal.
Published Date: 
October, 2007

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