A new gene for Tourette's syndrome: a window into causal mechanisms?

Mark McIntosh,'s picture
PubMed URL: 
http://www.ncbi.nlm.nih.gov/pubmed/16678301
Author: 
Walkup JT
Author List: 
Grados MA
Walkup JT
Journal: 
Trends Genet
PubMed ID: 
16678301
Pagination: 
291-3
Volume: 
22
Issue: 
6
Abstract: 
Gilles de la Tourette syndrome (GTS) is a neurodevelopmental disorder characterized by impairing motor-vocal tics. Locating genetic loci by associating the phenotype with DNA translocations, inversions, gain or losses, State et al. identified SLITRK1 as a candidate gene in an individual with GTS and inv(13) (q31.1; q33.1). This gene was also associated with abnormal axonal-dendritic development in embryonic mouse cells. Although SLITRK1 is not a major causal gene for GTS, it can shed light on our understanding of the gene-based neural correlates of this disease.
Published Date: 
June, 2006

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