Separation anxiety disorder in OCD.

Mark McIntosh,'s picture
PubMed URL:
Samuels JF
Author List: 
Mroczkowski MM
Goes FS
Riddle MA
Grados MA
Bienvenu OJ 3rd
Greenberg BD
Fyer AJ
McCracken JT
Rauch SL
Murphy DL
Knowles JA
Piacentini J
Cullen B
Rasmussen SA
Geller DA
Pauls DL
Liang KY
Nestadt G
Samuels JF
Depress Anxiety
PubMed ID: 
A history of separation anxiety disorder (SAD) is frequently reported by patients with obsessive-compulsive disorder (OCD). The purpose of this study was to determine if there are clinical differences between OCD-affected individuals with, versus without, a history of SAD.Using data collected during the OCD Collaborative Genetic Study, we studied 470 adult OCD participants; 80 had a history of SAD, whereas 390 did not. These two groups were compared as to onset and severity of OCD, lifetime prevalence of Axis I disorders, and number of personality disorder traits.OCD participants with a history of SAD were significantly younger than the non-SAD group (mean, 34.2 versus 42.2 years; P<.001). They had an earlier age of onset of OCD symptoms (mean, 8.0 versus 10.5 years; P<.003) and more severe OCD, as measured by the Yale-Brown Obsessive Compulsive Scale (mean, 27.5 versus 25.0; P<.005). In addition, those with a history of SAD had a significantly greater lifetime prevalence of agoraphobia (odds ratio (OR) = 2.52, 95% confidence interval (CI) = 1.4-4.6, P<.003), panic disorder (OR = 1.84, CI = 1.03-3.3 P<.04), social phobia (OR = 1.69, CI 1.01-2.8, P<.048), after adjusting for age at interview, age at onset of OCD, and OCD severity in logistic regression models. There was a strong relationship between the number of dependent personality disorder traits and SAD (adjusted OR = 1.42, CI = 1.2-1.6, P<.001).A history of SAD is associated with anxiety disorders and dependent personality disorder traits in individuals with OCD.
Published Date: 
March, 2011

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