Metabolites in ventricular cerebrospinal fluid detected by proton magnetic resonance spectroscopic imaging.

Mark McIntosh,'s picture
PubMed URL: 
http://www.ncbi.nlm.nih.gov/pubmed/15332258
Author: 
Barker PB
Author List: 
Nagae-Poetscher LM
McMahon M
Braverman N
Lawrie WT Jr
Fatemi A
Degaonkar M
Horská A
Pomper MG
Chacko VP
Barker PB
Journal: 
J Magn Reson Imaging
PubMed ID: 
15332258
Pagination: 
496-500
Volume: 
20
Issue: 
3
Abstract: 
Normally, ventricular cerebrospinal fluid (CSF) contains low levels of all metabolite signals on proton magnetic resonance spectroscopic imaging (MRSI). We present here three cases (two with seizure disorders, one with a central nervous system lymphoma) who presented with unusually elevated CSF signals on MRSI. Based on chemical shifts and in vitro studies (in one case), the signals were assigned to propan-1,2-diol (PD), acetone, and lactate, respectively. These compounds were either exclusively, or more readily, detected in CSF than in brain. Proton MRSI conveniently screens both brain and CSF for abnormal metabolism simultaneously.
Published Date: 
September, 2004

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