A dual DTI approach to analyzing white matter in children with dyslexia.

Mark McIntosh,'s picture
PubMed URL: 
http://www.ncbi.nlm.nih.gov/pubmed/19346108
Author: 
Kaufmann WE
Author List: 
Carter JC
Lanham DC
Cutting LE
Clements-Stephens AM
Chen X
Hadzipasic M
Kim J
Denckla MB
Kaufmann WE
Journal: 
Psychiatry Res
PubMed ID: 
19346108
Pagination: 
215-9
Volume: 
172
Issue: 
3
Abstract: 
Using voxel-based (VBA) and region-of-interest (ROI) diffusion tensor imaging (DTI) analyses, we examined white matter (WM) organization in seven children with dyslexia and six age-matched controls. Both methods demonstrated reduced fractional anisotropy (FA) in the left superior longitudinal fasciculus (SLF) and abnormal orientation in the right SLF in dyslexics. Application of this complementary dual DTI approach to dyslexia, which included novel analyses of fiber orientation, demonstrates its usefulness for analyzing mild and complex WM abnormalities.
Published Date: 
June, 2009

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