Proton magnetic resonance spectroscopy in obsessive-compulsive disorder: a pilot investigation comparing treatment responders and non-responders.

Mark McIntosh,'s picture
PubMed URL: 
http://www.ncbi.nlm.nih.gov/pubmed/17904826
Author: 
Hoehn-Saric R
Author List: 
Mohamed MA
Smith MA
Schlund MW
Nestadt G
Barker PB
Hoehn-Saric R
Journal: 
Psychiatry Res
PubMed ID: 
17904826
Pagination: 
175-9
Volume: 
156
Issue: 
2
Abstract: 
Proton magnetic resonance spectroscopic imaging was performed to compare brain metabolism in patients with obsessive-compulsive OCD. Evaluation was done on responders and non-responders to pharmacotherapy and on healthy controls. The results showed significantly lower NAA/Cr ratios in the right basal ganglia in non-responders than in responders or in controls and higher Cho/Cr ratios in the right thalamus in non-responders than responders. Abnormal neuronal metabolism in the right basal ganglia and right thalamus may be indicating lack of response to treatment to selective serotonin reuptake inhibitor.
Published Date: 
November, 2007

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