The Scheduled for Affective Disorders and Schizophrenia for School-Aged Children (K-SADS) is the most widely used and well validated diagnostic interview for children and adolescents. The paper-and-pencil version of the K-SADS has been translated into over 30 different languages, and it has been the diagnostic instrument utilized in multiple NIH- and pharmaceutical industry-sponsored studies. Many of the clinical trials that employed the K-SADS have resulted in changes in pediatric drug labeling by the Food and Drug Administration (FDA). The K-SADS has also been used as a validation instrument in large-scale epidemiological studies of psychiatric disorders in youth. Through federal funds from the National Institute of Mental Health, under Small Business Innovation Research (SBIR) grant number R44 MH094092 to the Center for Telepsychology (KK), Yale University (JK), and Kennedy Krieger Institute (JK), and support from the Zanvyl and Isabelle Krieger Fund (JK), we developed three web-based computerized versions of the K-SADS: a clinician-administered version; a self-administered youth version; and a self-administered parent version.