Holoprosencephaly (HPE)

Millions Around World To Observe Rare Disease Day

January 14, 2011
World Rare Disease Day on February 28, 2011

(Baltimore, MD) Kennedy Krieger Institute will be joining the National Organization for Rare Disorders (NORD) and others around the world in observing World Rare Disease Day on February 28, 2011. On this day, millions of patients and their families will share their stories to focus a spotlight on rare diseases as an important global public health concern.

Rare Brain Abnormalities Often Misdiagnosed in Patients

April 19, 2004
National Institutes of Health and Kennedy Krieger Host Awareness Conference for Parents, Clinicians and Researchers

Baltimore- In a new study, researchers at Kennedy Krieger Institute have found that a significant number of children with severe brain disorders are being misdiagnosed, potentially affecting treatment and outcome.

Brain Malformations

To find patient care programs and faculty treating brain malformations at Kennedy Krieger Institute, as well as research investigating this disorder, please see the right-hand column below. Additional helpful information, including definitions, symptoms, Institute press releases, Potential magazine articles, and other resources outside the Institute, have also been provided for readers on this page.

Holoprosencephaly (HPE)

Holoprosencephaly (HPE) is a birth defect that occurs during the first few weeks of intrauterine life. HPE is a disorder in which the fetal brain does not grow forward and divide as it is supposed to during early pregnancy (incomplete cleavage of the embryonic forebrain/failure of the prosencephalon to cleave into the cerebral and lateral hemispheres).

This brain malformation can range from mild to severe and is classified into three types:

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