HUGO MOSER RESEARCH INSTITUTE OVERVIEW

Kennedy Krieger’s scientists and researchers are leaders in the worldwide effort to prevent and treat disorders of the brain, spinal cord, and musculoskeletal system.  Our investigators continue to break new ground with innovative magnetic resonance imaging technology, investigate critical areas, such as the role of genetics in developmental disorders, and develop new treatment models and therapies. Kennedy Krieger is committed to sharing our knowledge that can be adapted and used by other healthcare organizations to benefit patients across the country and around the world.

Learn more about the Hugo Moser Research Institute's innovative research initiatives and latest findings:

Research Frontiers      Research Updates

Professional Training Overview

Kennedy Krieger dedicates substantial resources to increasing the number of qualified specialists in the fields of neurological and developmental disabilities. We also take seriously our responsibility not only to improve care through research, but to share that knowledge with others. That is why more than 400 individuals come here to train in a wide variety of disciplines each year. The goals of the Institute’s clinical training programs are twofold: 1) to train leaders in the field of neurodevelopmental disabilities and 2) to help ensure that there is a sufficient number of qualified professionals to meet the needs of children with special health care needs and their families. By training future generations of researchers and professionals – from undergraduate students to current staff – we are ensuring that children everywhere can receive the best possible care.

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A National Research Resource Center for Functional Brain Imaging Technology

The only children's hospital designated as a NIH National Research Resource for functional brain imaging, Kennedy Krieger is breaking new ground with innovative fMRI technology.
Understanding Behaviors Through Observational Research

Discovering the environmental and biological basis of behavior is crucial to understanding and improving treatment outcomes for a wide variety of developmental disorders.
Motion Analysis Research and Laboratory

Using 3D modeling and other innovative technologies, our researchers are studying new methods to improve walking patterns in those with brain injuries.
IAN Research: Advancing Research, Empowering Advocates, Interpreting Findings

The Interactive Autism Network (IAN) is the nation's largest online autism research effort. IAN Research collects data from families online and matches them to studies nationwide.

HUGO MOSER RESEARCH INSTITUTE OVERVIEW

Kennedy Krieger’s scientists and researchers are leaders in the worldwide effort to prevent and treat disorders of the brain, spinal cord, and musculoskeletal system.  Our investigators continue to break new ground with innovative magnetic resonance imaging technology, investigate critical areas, such as the role of genetics in developmental disorders, and develop new treatment models and therapies. Kennedy Krieger is committed to sharing our knowledge that can be adapted and used by other healthcare organizations to benefit patients across the country and around the world.

Learn more about the Hugo Moser Research Institute's innovative research initiatives and latest findings:

Research Frontiers      Research Updates

Participate in Research

Over the years, Kennedy Krieger’s scientists and researchers have made crucial medical discoveries that have led to innovative treatments and improved patient care for individuals with disorders of the brain, spinal cord and musculoskeletal system. Learn more about current research studies you can participate in by visiting our recruiting research studies page. View studies
 
CLINICAL TRIALS STUDIES
 
The Clinical Trials Unit at Kennedy Krieger Institute brings together patients and families, research scientists and private industry to unlock the potential of new treatments to treat, cure and prevent genetic and developmental disorders. Learn more

Current Research Projects

Novel Approaches for CEST Labeling, Detection, Quantification, and Translation
Principal Investigator: Van Zijl, Peter
The overall Program Project focuses on the design and detection of bioorganic biodegradable Chemical Exchange Saturation Transfer (CEST) agents, with the ultimate goal of their practical application...
Magnetic Resonance Spectroscopy Imaging as a Biomarker for FSHD
Principal Investigator: Wagner, Kathryn
Sponsored by the American Academy of Neurology -- 2011 AAN Clinical Research Training Fellowship. Recent advances in the study of heritable neuromuscular disorders have led to multiple promising...
Biomarkers of Facioscapulohumeral Muscular Dystrophy (FSHD)
Principal Investigator: Wagner, Kathryn
This NIH-funded study is established to identify biomarkers for facioscapulohumeral muscular dystrophy (FSHD). FSHD patients and their unaffected first degree relative will undergo open muscle biopsy...
Duchenne Muscular Dystrophy: Double-Blind Randomized Trial to Find The Optimum Steroid Regimen (FOR-DMD)
Principal Investigator: Wagner, Kathryn
This Phase III multi-center, double-blind, parallel group, 36 - 60 month study funded by the NIH will compare three corticosteroid regimens in wide use in DMD: 1) daily prednisone (0.75 mg/kg/day); 2...
HALO-DMD-01: A Phase 1b Open Label, Single and Multiple Ascending Dose Study to Evaluate the Safety, Tolerability, and Pharmacokinetics (PK) of HT-100 in Patients with Duchenne Muscular Dystrophy
Principal Investigator: Wagner, Kathryn
The study, sponsored by HALO Therapeutics, is designed to provide initial safety, tolerability, and PK data of halofuginone hydrobromide, HT-100, in young boys ages 6-20 years with DMD.  HT-100...
HALO-DMD-02: An Open Label Extension Study of HT-100 in Patients with Duchenne Muscular Dystrophy who have Completed Protocol HALO-DMD-01
Principal Investigator: Wagner, Kathryn
This open-label, multiple dose extension study is designed to evaluate the safety, tolerability, pharmacodynamic signals, and population PK of HT-100, a delayed-release, orally-delivered agent in...
Myostatin regulates fate of satellite cells in dystrophic muscle
Principal Investigator: Wagner, Kathryn
The goal of this proposal is to determine whether myostatin, expressed in both skeletal muscle and fibroblasts, regulates the conversion of satellite cells to fibroblasts and whether this conversion...
Biomarkers for Therapy of FSHD
Principal Investigator: Wagner, Kathryn
The goal of this Senator Paul D. Wellstone Muscular Dystrophy Cooperative Research Center is to define modifying genes of FSHD and to determine, through novel animal models of FSHD, whether these are...
A Three Dimensional Environment for Skeletal Muscle Stem Cell Transplantation
Principal Investigator: Wagner, Kathryn
The purpose of this collaborative project is to develop and test and injectable scaffold embedded with muscle stem cells and a Pfizer drug to facilitate muscle regeneration. Cell based therapies...
Acupressure and Acupuncture as an Intervention with Children with Autism II
Principal Investigator: Warren, Lana
The purpose of this feasibility study is to see if children with autism spectrum disorder (ASD) will tolerate an acupressure and acupuncture intervention twice weekly over a 3 month period of time...
Acyl-CoA Synthetase ACSVL3 in Malignant Glioma: Metabolism and Oncogenic Cellular
Principal Investigator: Watkins, Paul
Malignant glioma accounts for a significant percentage of brain tumors. As these tumors are typically refractory to treatment, there is a need for new and novel therapeutic approaches. Levels of...
Modeling Aggressive Medulloblastoma Using Human Induced Pluripotent Stem Cells
Principal Investigator: Ying, Mingyao
Brain tumors are the most common cause of childhood oncological death, and medulloblastoma (MB) is the most common malignant pediatric brain tumor. Group 3 MB is characterized by amplification and...
Mechanisms of Locomotor Recovery in Multiple Sclerosis
Principal Investigator: Zackowski, Kathleen
The study will test the general hypothesis that, in multiple sclerosis (MS) and following an acute exacerbation, damage of cerebellar white matter tracts (i.e. cerebellar peduncles) will show greater...
Understanding Mechanisms of Lower Extremity Strengthening in Women Heterozygous for X-ALD
Principal Investigator: Zackowski, Kathleen
Sponsored by the ELA Foundation. X-linked adrenoleukodystrophy (X-ALD), a sex-linked progressive neurodegenerative disease, is caused by a defect in the ABCD1 gene. The disease is expressed in...
Predicting Intervention Responsiveness to Improve Rehabilitation in People with Multiple Sclerosis
Principal Investigator: Zackowski, Kathleen
Sponsored by the National Multiple Sclerosis Society -- RG 4668-A-1. Multiple sclerosis (MS) is an inflammatory disease of the central nervous system (CNS) distinguished pathologically by...
Creating a Pediatric Imaging-Genomics Data Resource
Principal Investigator: Mostofsky, Stewart
Along with investigators at 8 other sites across the U.S., we will assemble a large, cross-sectional imaging-genomics dataset. The major aim of our proposal is to create a database that is...
Anomalus Motor Physiology in ADHD
Principal Investigator: Mostofsky, Stewart
The hypothesis of this study is that the neuromotor anomalies present in children with ADHD will be associated with deficient intracortical and interhemispheric inhibition of the motor cortex. This...
Neurologic basis of inhibitory deficits in ADHD
Principal Investigator: Mostofsky, Stewart
Prevailing hypotheses implicate deficient response inhibition as one of the fundamental features driving the pathophysiology of ADHD. Results from studies of lesions in animals and humans led many...
Tourette Syndrome: Functional Imaging of Motor Activation Pathways in Verbal and Motor Tics
Principal Investigator: Mostofsky, Stewart
Tourette Syndrome (TS) is a disorder characterized by frequent motor and verbal tics. The exact mechanism of tic generation and the pathophysiology of TS is widely debated but believed to be related...
Motor skill learning in autism: assessment and treatment of altered patterns of learning.
Principal Investigator: Mostofsky, Stewart
Detailed study of motor impairments in autism can provide valuable insights into the neural basis of the disorder and help to guide its treatment. Given the developmental nature of autism, during the...
Motor Skill Learning in Autism
Principal Investigator: Mostofsky, Stewart
Abnormalities on motor examination have often afforded valuable insights into developmental disorders of the brain; such abnormalities have been well documented in individuals with autism and, in...
Neurology of Deficient Response Control in ADHD
Principal Investigator: Mostofsky, Stewart
Building on evidence established in the initial grant period, the overall goals of the proposed study, “Neurology of Deficient Response Control in ADHD,” are to apply advanced neuroimaging and...
Tourette Syndrome Neuroimaging Consortium Pilot
Principal Investigator: Mostofsky, Stewart
Important research on Tourette Syndrome (TS) is proceeding along several fronts, from gene-hunting to controlled trials of new treatments. The Tourette Syndrome Association (TSA) has fostered...
Anomalous Motor Physiology in ADHD: Inhibitory and Reward Mechanisms
Principal Investigator: Mostofsky, Stewart
Attention Deficit Hyperactivity Disorder (ADHD), the most common behavioral diagnosis in children, incurs high medical costs and results in poor academic achievement, adult mental illness, substance...
Movement-Based Mindfulness Training for Children with ADHD: A Feasibility Study
Principal Investigator: Mostofsky, Stewart
Attention Deficit Hyperactivity Disorder (ADHD) has tremendous individual and societal impact. Current standard treatments can provide short-term reductions in symptom severity; however, there...
Tactile Adaptation in Tourette Syndrome: Probing GABA-Mediated Neuroplasticity
Principal Investigator: Mostofsky, Stewart
Tourette Syndrome (TS) is a common developmental neuropsychiatric disorder that can have a substantial impact on quality of life. Despite being first described over a century ago, the neurobiology of...
Quality Assurance of Sequential Finger Tapping Task Data Received from the University of Iowa
Principal Investigator: Mostofsky, Stewart
This application is being submitted in order to assess with task development of Brain Structure and Function in Juvenile Huntington Disease at Roy J. & Lucille A. Carver College of Medicine....
Adolescent Changes in Brain and Behavior in Boys and Girls with ADHD
Principal Investigator: Mostofsky, Stewart
Children with ADHD are at risk for a host of deleterious outcomes including impaired social relations, academic difficulties, criminality, and comorbid psychopathology (substance use, depression,...
Pathogenesis of Rett Syndrome
Principal Investigator: Naidu, SakkuBai
This is an observational study of the natural history and clinical course of Rett Syndrome (RTT), a neurodevelopmental disorder primarily affecting females, caused by mutations in the MeCP2 gene. Our...
KKI Weblink for researchers in Rett Syndrome
Principal Investigator: Naidu, SakkuBai
Creation of a Weblink for Researchers in Rett syndrome to request de-identified data from clinical evaluations collected on our patients with Rett syndrome (RTT) in The Natural History study "...
Dextromethorphan in Rett syndrome
Principal Investigator: Naidu, SakkuBai
Dr. SakkuBai Naidu of the Kennedy Krieger Institute is initiating a clinical drug trial using dextromethorphan (DM) in Rett Syndrome (RTT) at the Pediatric Clinical Research Unit (PCRU) of the Johns...
Placebo-Controlled Trial of Dextromethorphan in Rett Syndrome
Principal Investigator: Naidu, SakkuBai
Dr. Sakkubai Naidu, Principal Investigator, is initiating a double blinded placebo controlled clinical drug trial using dextromethorphan (DM) in Rett Syndrome (RTT), at the Pediatric Clinical...
Human Induced Pluripotent Stem Cells (hiPSC) in Rett syndrome
Principal Investigator: Naidu, SakkuBai
Skin biopsy will be obtained for fibroblast culture from patients with a known MECP2 mutation as well as skin fibroblasts already present in the KKI’s tissue repository from patients with known...
Functional Connectivity ToolKit
Principal Investigator: Pekar, James
Functional connectivity (FC) is defined as synchrony between neural signals from different locations; collections of regions displaying consistent synchrony are referred to as networks. Spontaneous...
Chromosomal abnormalities underlying developmental disabilities
Principal Investigator: Pevsner, Jonathan
The research question we would like to address is whether children with developmental disabilities have identifiable chromosomal abnormalities. The approach is in four parts:(1) prescreen and recruit...
Analysis of Genetic Variation in Neurodevelopmental Disorders
Principal Investigator: Pevsner, Jonathan
We propose to sequence genomic DNA from patients with neurodevelopmental disorders, including autism, to study the nature and extent of genetic variation. To do this, the PI’s laboratory will study...
Pediatric Constraint-Induced Movement Therapy for Children with Hemiparesis: Outcomes of a Clinical Model
Principal Investigator: Pidcock, Frank
Does the function of children with hemiparesis improve after treatment involving constraint of the less impaired upper extremity in conjunction with intensive therapies? We will investigate this...
Using Xbox Kinect based sensory technology to improve the functional mobility by allowing remote monitoring and modification of therapeutic activities for children with Cerebral Palsy in the home
Principal Investigator: Pidcock, Frank
This is a small fesibility study where Kennedy Krieger will partner with Richard Simpson a rehabilitation engineer to provide the therapeutic and technologic resources for developing and implementing...
Developmental Trajectories of Impairments, Associated Health Conditions, and Participation of Children with Cerebral Palsy
Principal Investigator: Pidcock, Frank
The purpose of this research study is to fill the gaps in fundamental knowledge of Cerebral Palsy by determining how children with cerebral palsy or with gross motor delay change in their balance,...
Retrospective analysis of risk factors associated with auditory processing disorder: SCAN-3 vs. LiSN-S
Principal Investigator: Pillion, Joseph
Due to their complexity and variability, disorders involving auditory processing lack a consistent definition and diagnostic criteria. These disorders are characterized by difficulty comprehending of...
Why parents choose or decline Complementary and Alternative Medicine services in the acute pediatric inpatient rehabilitation setting
Principal Investigator: Prestwich, Suzanne
Complementary and Alternative Medicine (CAM) usage in the general population is becoming more common as is usage in children. Use in children with chronic illness such as oncology patients, ADHD and...
Construct and Predictive Validity of the Capute Scales
Principal Investigator: Pritchard, Alison
Primary care physicians (PCPs) are often presented with the responsibility of early identification of developmental delay and other types of disorders, due to their early and ongoing contact with...
Accommodations for ADHD: Are They Effective in Reducing the Impact of the Disorder?
Principal Investigator: Pritchard, Alison
One of the most important functions served by a pediatric neuropsychological assessment is the provision of evidence-based recommendations and resources designed to reduce symptoms and improve...
Outpatient Research Registry
Principal Investigator: Pritchard, Alison
The primary objective of this protocol is to gather information on Neuropsychology outpatients that can later be accessed for screening purposes (to determine eligibility for research studies...
Executive Function and Academic Achievement in Children with a History of Prematurity
Principal Investigator: Pritchard, Alison
The proposed study will be a retrospective review of previously collected clincal neuropsychological testing data, which will be deidentified for the purpose of this research study. The first...
Effect of glycerol trierucate on clinical course of Adrenoleukodystrophy
Principal Investigator: Raymond, Gerald
Adrenoleukodystrophy is a disorder of very long chain fatty acids secondary to defects in peroxisomal beta oxidation. The accumulation of these fatty acids results in a disorder of the adrenal glands...
Virtual Sailing Simulator in Individuals with Spinal Cord Injury
Principal Investigator: Recio, Albert
The benefits of sport and recreational activities for the disabled are well recognized from the standpoint of health and quality of life. Yet there remains a lack of options for most disabled people...
Collaborative Assessment of Pediatric Transverse Myelitis; Understand, Reveal, Educate. CAPTURE Study
Principal Investigator: Recio, Albert
Currently, there are no uniform outcome measures to assist in guiding therapies. This multi center study proposes a unique opportunity to examine the outcomes of acute treatment and potentially...
Assessing the Impact of Skin Tears on Goal-Directed Therapy Plans Among Individuals with Traumatic Spinal Cord Injury (SCI)
Principal Investigator: Recio, Albert
To explore how skin tears affect therapy plans in order to promote an optimal wound healing environment and, describe how this modification may influence the achievement of therapy goals among...
Developmental Outcomes in Children with Unilateral and Mild/Moderate Hearing Loss
Principal Investigator: Reesman, Jennifer
The primary goal of the present study is to begin to develop a program of research to capture developmental outcomes in children with hearing loss, with a current focus on unilateral (UL) and mild/...
Cognitive, Behavioral, and Educational Outcomes in At-Risk Children with Hearing Loss
Principal Investigator: Reesman, Jennifer
Children with hearing loss are at increased risk for poor cognitive, behavioral and educational outcomes. The present study seeks to identify correlates of poor outcomes and identify predictors via a...
Utility of the Immediate and Post-Concussion Assessment and Cognitive Testing (ImPACT) test with Deaf and Hard-of-Hearing Adolescents
Principal Investigator: Reesman, Jennifer
The present research seeks to examine whether the ImPACT test provides an accessible means of assessment for adolescents who are deaf or hard-of-hearing, as this tool has not previously been...
Validation of a Modified Signed Paired Associates Test for Deaf Children
Principal Investigator: Reesman, Jennifer
There are no published measures available that assess language related memory for children who communicate using American Sign Language (ASL). Most memory measures are created using spoken language,...
Individualizing Learning Arrangements for Children with Intellectual Disabilities
Principal Investigator: Rooker, Griffin
The frequent and immediate delivery of reinforcers (rewards) following completion of academic tasks and related activities is an integral part of many educational programs for children with...
Facial Dysmorphology in Children with Intellectual and Developmental Disabilities
Principal Investigator: Rooker, Griffin
Recent literature has demonstrated an association between autism spectrum disorders and characteristic dysmorphologies of the face and brain. The current study extends this line of investigation by...
Delay Discounting in Children with ADHD: Neuroimaging and Behavioral Correlates
Principal Investigator: Rosch, Keri
The ability to inhibit a response to an immediately available reward in pursuit of a larger or more valuable, albeit delayed, reward is a critical component of cognitive, emotional, and social...
Relation of Severity of injury with Testosterone profile & osteoporosis in spinal cord injured men
Principal Investigator: Sadowsky, Cristina
Hypothesis: Higher spinal cord injury neurologic level correlates with decreased testosterone level and increased prevalence of secondary osteoporosis.  Spinal cord injury is more common in...
Incidence of Osteoporosis in Patients with Chronic Spinal Cord Dysfunction
Principal Investigator: Sadowsky, Cristina
Research Question: Prevalence of osteoporosis in patients with traumatic and non-traumatic spinal cord injury. Secondary Question: Relationship between bone mass, injury level and grade (ASIA), total...
Patterned FES Ergometry of Arm and Shoulder in Individuals with Spinal Cord Injury
Principal Investigator: Sadowsky, Cristina
Recent evidence suggests that FES can improve certain functions in the Central Nervous System (CNS) following injury or disease; it can enhance motor recovery, change H reflex and flexor reflex...
Relation of HDL levels with home based Activity Based Restorative Therapies in spinal cord injured adults
Principal Investigator: Sadowsky, Cristina
Hypothesis: HDL levels increase following home based Activity Based Restorative Therapies (ABRT) The effect of exercise on lipid profile is well documented in the able bodied population. The effect...
Pediatric Multicenter Evaluation of Notable SCI Outcome Instruments, evaluation of Outcome Instruments when Applied to Children
Principal Investigator: Sadowsky, Cristina
The overall objective of this research project is to establish pediatric psychometric support (usability, reliability, validity) of outcomes instruments that have been recommended for use in spinal...
Linking Adult and Pediatric Outcomes Instruments
Principal Investigator: Sadowsky, Cristina
To validate the estimates used to link the Shriners Hospitals for Children (SHC) pediatric spinal cord injury (SCI) general mobility, manual mobility, power mobility and daily routine computer...
SIMS -- Spinal Cord Injury Management System
Principal Investigator: Sadowsky, Cristina
To define the treatment modality and co-factor variables which influence the response to Activity Based Restorative Therapies (ABRT) in individuals with Spinal Cord Injury (SCI). To define the dose...
The Association Between Lean Body Mass and Functional Outcomes in Individuals with Spinal Cord Injury
Principal Investigator: Sadowsky, Cristina
What is the correlation between lean body mass (LBM) and functional outcome in individuals with spinal cord injury (SCI)? We plan to determine the association between (LBM) and functional outcomes as...
The Efficacy of Aquatic Locomotor Training Compared to Overground Locomotor Training in Improving Ambulatory Function and Health-Related Quality of Life
Principal Investigator: Sadowsky, Cristina
The aim of this study is to define and evaluate the efficacy of ALT compared to overground LT in improving ambulatory function and health-related quality of life. We hypothesize, that ALT is capable...
ArmAware: a novel device to treat hemiplegia and hemispatial neglect
Principal Investigator: Salorio, Cynthia
The Investigators have developed a novel therapeutic device called ArmAware, that is designed to be an adjunctive treatment for adults and children with hemiparesis (weakness on one side of the body...
Comorbidities in Children and Adolescents with Seizures
Principal Investigator: Salorio, Cynthia
This current study will examine symptoms of inattention, hyperactivity, anxiety, and mood problems in a large, clinical sample of children and adolescents with epilepsy. In addition to identifying...
Sedation Strategy and Cognitive Outcome After Critical Illness in Early Childhood: RESTORE-Cognition
Principal Investigator: Salorio, Cynthia
The purpose of RESTORE-cognition is to determine the relationships between sedative exposure during pediatric critical illness and long-term neurocognitive outcomes. We will assess multiple domains...
The Osteogenesis Imperfecta Registry
Principal Investigator: Shapiro, Jay
The development and operation of a national registry for individuals with osteogenesis imperfecta.
Longitudinal Study of Brittle Bone Disease
Principal Investigator: Shapiro, Jay
The objective of this protocol is to conduct a longitudinal multidisciplinary investigation of the natural history, current therapeutic interventions, morbidity, and mortality in people with OI. The...

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